Depression in Patients with Heart Failure: Is Enough Being Done?

Mbakwem, Amam; Aina, F; Amadi, Casmir

doi:10.15420/cfr.2016:21:1

Cited by 44 publications

(59 citation statements)

References 56 publications

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“…Moreover, the HDRS questionnaire was found to be the most sensitive tool for testing the depressive symptoms among patients with vitiligo. Previous studies had demonstrated that depression was a frequent comorbidity in patients with chronic diseases such as diabetes, 27 Parkinson's disease 28 and heart failure 29 . Vitiligo is the most common depigmenting disorder and up to now there are no effective or satisfactory treatments for the illness.…”

Section: Discussionmentioning

confidence: 99%

The prevalence and odds of depression in patients with vitiligo: a meta‐analysis

Wang

Qiu

Yang

et al. 2018

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 99%

The prevalence and odds of depression in patients with vitiligo: a meta‐analysis

Wang

Qiu

Yang

et al. 2018

Acad Dermatol Venereol

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“…Plasma levels of natriuretic peptides are elevated in congestive heart failure. One study reported these have an antagonistic effect on blood pressure and fluid neurotransmitters in HF and are associated with the emotional and mental changes seen in HF [39]. Further investigating this concept, Herrmann-Lingen, et al, (2003) reported that anxiety tends to reduction with high atrial natriuretic pro-Peptide levels [40].…”

Section: The Link Between Heart Failure Depression and Anxietymentioning

confidence: 99%

Mental Ill-Health and Heart Failure Comorbidity

Ahmed

Morrissey

Ball

2019

Int J Curr Pharm Sci

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This review aims to understand the co-existence of mental ill-health and heart failure and if this comorbidity affects patient self-care motivation and overall health outcomes. Databases searched were; PubMed®, Google® scholar and Science Direct® for studies related to heart failure, heart failure and mental health, depression and anxiety. Eleven articles were identified and reviewed. There were two studies disagreed with the theory that the mental ill-health and heart failure has disease modification and worsen patient health outcomes, three studies concluded that only anxiety has effect, five studies concluded that both anxiety and depression have effect, six studies concluded that depression only has effect but all eleven stated that more research is required. Recent theories on depression and cardiovascular disease comorbidity and the effect mental ill-health have on medication adherence in heart failure patients was discussed. People with long-term physical illnesses may suffer further complications to their health if they develop mental illness; increasing the cost of their care by an average of 45%, however, in the majority of these cases, the mental issues neither diagnosed nor treated. This review explored the link between cardiovascular disease (CVD) and mental ill health; and how comorbidity of the two conditions affects patients' adherence to therapy behaviour. It was concluded that while the link between mental ill health and heart failure (HF) is recognized, studies that may be used as a basis of evidence to confirm this link are scarce.

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“…The vast majority of cardiovascular disease-related deaths (85%) can be attributed to stroke and heart failure (HF) with their accompanying detrimental effects on the human body, albeit there might be substantial geographic differences in survivability rates (1). A growing body of clinical studies suggests a high degree of comorbidity between cardiovascular diseases and cognitive impairments and emotional distress (2)(3)(4). In fact, 20-40% of all HF patients develop major depression and display anxiety levels signi cantly higher than the healthy population (2,3,5,6), which usually appear later than the cardiovascular and autonomic-related symptoms (7).…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats

Althammer

Ferreira‐Neto

Rubaharan

et al. 2020

Preprint

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Background Cardiovascular diseases, including heart failure are the most common cause of death globally. Recent studies support a high degree of comorbidity between heart failure and cognitive and mood disorders resulting in memory loss, depression and anxiety. While neuroinflammation in the hypothalamic paraventricular nucleus contributes to autonomic and cardiovascular dysregulation in heart failure, mechanisms underlying cognitive and mood disorders in this disease remain elusive. The goal of this study was to quantitatively asses markers of neuroinflammation (glial morphology, cytokines and A1 astrocyte markers) in the central amygdala, a critical forebrain region involved in emotion and cognition, and to determine its time course and correlation to disease severity during the progression of heart failure.Methods We developed and implemented a comprehensive microglial/astrocyte profiler for precise three-dimensional morphometric analysis of individual microglia and astrocytes in specific brain nuclei at different time points during the progression of heart failure. To this end, we used a well-established ischemic heart failure rat model. Morphometric studies were complemented with quantification of various pro-inflammatory cytokines and A1/A2 astrocyte markers via qPCR. Results We report structural remodeling of central amygdala microglia and astrocytes during heart failure that affected cell volume, surface area, filament length and microglial branches, resulting overall in somatic swelling and deramification, indicative of a change in microglial state. These changes occurred in a time-dependent manner, correlated with the severity of heart failure, and were delayed compared to changes in the hypothalamic paraventricular nucleus. Morphometric changes correlated with elevated mRNA levels of pro-inflammatory cytokines and markers of reactive A1-type astrocytes in the paraventricular nucleus and central amygdala during heart failure. Conclusion We provide evidence that in addition to the previously described hypothalamic neuroinflammation implicated in sympathohumoral activation during heart failure, microglia and astrocytes within the central amygdala also undergo structural remodeling indicative of glial shifts towards activated and pro-inflammatory phenotypes, respectively. Thus, our studies suggest that neuroinflammation in the amygdala stands as a novel pathophysiological mechanism and potential therapeutic target for that could be associated with emotional and cognitive deficits commonly observed at later stages during the course of heart failure.

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Depression in Patients with Heart Failure: Is Enough Being Done?

Cited by 44 publications

References 56 publications

The prevalence and odds of depression in patients with vitiligo: a meta‐analysis

The prevalence and odds of depression in patients with vitiligo: a meta‐analysis

Mental Ill-Health and Heart Failure Comorbidity

Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats

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