Depression in patients with Parkinson's disease: Impact on functioning

Stella, Florindo; Banzato, Cláudio E. M.; Quagliato, Elizabeth Maria Aparecida Barasnevicius; Viana, Maura Aparecida

doi:10.1016/j.jns.2008.05.018

Cited by 22 publications

(12 citation statements)

References 33 publications

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“…Potential risk factors for depression in PD include: female gender, advanced age, cognitive impairment, comorbidity with anxiety, increased severity of the disease, rigid-akinetic variant of PD, postural instability, motor signs nonresponsible to levodopa, and familial history of PD. Patients with comorbid depression have worse motor performance and cognitive functioning when compared to non-depressed patients 8 . The frequency of death and suicidal ideation in these patients are particularly high, although suicide plans and attempts are fortunately rare.…”

Section: Depressionmentioning

confidence: 97%

Neuropsychiatry of Parkinson's disease

Kümmer

Teixeira

2009

Arq. Neuro-Psiquiatr.

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-Parkinson's disease (PD) is traditionally regarded as a movement disorder. In recent years, however, non-motor symptoms have been considered significant factors of disability at all stages of the illness. Behavioral and psychological symptoms or neuropsychiatric syndromes associated with PD are frequent and may represent a challenge in the management of these patients. They include anxiety, depression, psychosis, sleep, sexual and impulse control disorders, apathy and cognitive dysfunction. Their pathogenesis in PD is complex, involving neurodegenerative, drug-related and psychological mechanisms. We will review the current knowledge of this growing field, also focusing on the management of theses syndromes.KEY WORDS: Parkinson's disease, neuropsychiatry, psychology, psychiatric disorders. Neuropsiquiatria da doença de ParkinsonResumo -A doença de Parkinson (DP) é tradicionalmente conhecida como um distúrbio do movimento. Entretanto, os sintomas não-motores têm sido considerados recentemente como fatores relevantes de incapacidade em todos os estágios da doença. Sintomas motores e comportamentais ou síndromes neuropsiquiátricas associadas à DP são frequentes e seu manejo pode se tornar um verdadeiro desafio. São comuns quadros de ansiedade, depressão, psicose, distúrbios do sono, transtornos do controle do impulso, apatia e disfunções cognitivas. A patogênese desses transtornos na DP é complexa, envolvendo mecanismos degenerativos, psicológicos e relacionados ao tratamento. Neste artigo, revisamos o estado do conhecimento desse campo de interesse crescente, também enfocando o manejo dessas síndromes. PALAVRAS-CHAVE: doença de Parkinson, neuropsiquiatria, psicologia, transtornos psiquiátricos.

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Section: Depressionmentioning

confidence: 97%

Neuropsychiatry of Parkinson's disease

Kümmer

Teixeira

2009

Arq. Neuro-Psiquiatr.

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“…Depression commonly occurs in neurodegenerative diseases such as Alzheimer's disease (de Souza et al 2010; Raskind 2008; Teng et al 2008; Zec and Burkett 2008), Parkinson's disease (Gómez-Esteban et al 2009; Kulisevsky et al 2008; Simuni and Sethi 2008; Stella et al 2008), Lewy body disease (Fritze et al 2011; Takahashi et al 2009; Yamane et al 2011), and Huntington's disease (Paulsen et al 2005; Perlis et al 2010), but it has been suggested that depression itself, particularly in late life, may be an indication of latent neurodegeneration (Burgut et al 2006). An association has been seen between late-life depressed mood, anhedonia, apathy, anergia and higher lacunars volume in white matter, suggestive of a role of subcortical ischemic vascular disease in the pathogenesis of such late-life mood disorders (Lavretsky et al 2008).…”

Section: 0 Depression and Neurodegenerationmentioning

confidence: 99%

Neuroinflammation, Neurodegeneration, and Depression

2012

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Neurodegeneration and depression are two common co-morbid conditions, particularly within the aging population. Research has linked neuroinflammation as a major contributing factor to both of these diseases. The key to neuroinflammation effects on neurodegeneration and depression appears to lie within the dysregulation of the control and release of pro- and anti-inflammatory cytokines. This can come from an internal or external insult to the system, or from changes in the individual due to aging that culminate in immune dysregulation. The need to reduce neuroinflammation has led to extensive research into neuroprotectants. We discuss the efficacy found with nicotine, alcohol, resveratrol, curcumin, and ketamine. Our main focus will be on what research is telling us about the connections between neuroinflammation, neurodegeneration, and depression, and the hope that neuroprotectants research is giving people suffering from neurodegeneration and depression stemming from neuroinflammation. We will conclude by making suggestions for future research in this area.

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“…Unfortunately, dementia is often a consequence of Parkinson's disease with 60% of patients developing dementia by the end of a 12-year follow-up period (Buter et al, 2008). Parkinson's patients often develop depression (Stella et al, 2008). An increased inflammatory response to stress in depressed patients may also provide a link between depression and other diseases, including heart disease (Pace et al, 2006).…”

Section: Chronic Diseases and Inflammationmentioning

confidence: 99%

Interrupting the inflammatory cycle in chronic diseases—Do gap junctions provide the answer?

Green

Nicholson

2008

Cell Biology International

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A number of chronic diseases, including neurodegenerative, cardiovascular and metabolic disorders, are associated with genetic susceptibility. Some may originate on exposure to an environmental stimulus. Regardless of genetic predisposition or external stimulus, these chronic diseases, once triggered, share an inflammatory component making them effectively persistent "wounds". There is also increasing evidence that the presence of one disease can cause activation of another apparently unrelated disease, leading to multiple disorders via activation of an immune response that 'fast forwards' disease progression. Here we review common aspects of a number of chronic disease conditions, and put forward the proposal that gap junction modulation may provide an opportunity to break the inflammatory cycle that sustains and links these disorders.

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Depression in patients with Parkinson's disease: Impact on functioning

Cited by 22 publications

References 33 publications

Neuropsychiatry of Parkinson's disease

Neuropsychiatry of Parkinson's disease

Neuroinflammation, Neurodegeneration, and Depression

Interrupting the inflammatory cycle in chronic diseases—Do gap junctions provide the answer?

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