Depression in transgender adolescents under treatment with isotretinoin

Campos-Muñoz, Lucía; Lara, D. López‐De; Conde‐Taboada, Alberto; Casado, Ana María Martín; López‐Bran, Eduardo

doi:10.1111/ced.14194

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…Notably, transgender persons face substantially higher prevalence of depression, anxiety, and suicidality compared with cisgender persons [ 70 , 71 ]. In a case series of four transgender adolescents receiving isotretinoin for severe acne, two stopped treatment due to depression, anxiety, and self-harm [ 72 ]. Providers should screen and monitor for signs of depression and mental health comorbidity for transgender patients receiving isotretinoin, such as using the Patient Health Questionnaire-9 (PHQ-9) depression screening tool to monitor depression symptoms [ 73 ].…”

Section: Treatment Planmentioning

confidence: 99%

Treating Acne in Transgender Persons Receiving Testosterone: A Practical Guide

et al. 2022

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Transgender persons who undergo masculinizing hormone therapy experience a wide array of dermatologic effects as they initiate and maintain testosterone therapy. Acne is one of the most common adverse effects for many transmasculine patients receiving testosterone. Acne can worsen body image and mental health, with significant impact on quality of life in transgender patients. Specific training and awareness are needed for a clinically and culturally competent encounter while providing care for the transgender patient. This article provides a practical guide for the treatment of testosterone-induced acne in transmasculine patients. Recommendations on creating a welcoming clinical setting, taking a gender-inclusive history, and conducting a patient-centered physical examination relevant to acne care are provided. Assessment of reproductive potential and the appropriate contraceptive methods before prescribing acne treatment with teratogenic potential in transmasculine patients are examined. Interactions between acne treatments with gender-affirming therapies are explored. For patients with severe or treatment-refractory acne, indications, contraindications, and barriers to isotretinoin prescription, such as the US iPLEDGE program, are examined. Multidisciplinary approaches to acne care, involving mental health, reproductive health, gender-affirming hormone therapy and surgeries, are adopted to guide isotretinoin treatment.

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Section: Treatment Planmentioning

confidence: 99%

Treating Acne in Transgender Persons Receiving Testosterone: A Practical Guide

et al. 2022

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“…34 Given the overlapping adverse mental health effects of acne and minority stress secondary to TGD identity, TGD youth should be closely screened, monitored and referred for treatment of comorbid psychiatric disorders, but can safely be treated with isotretinoin. 32,35,36 The patient health questionnaire (PHQ-9) may be a useful clinical tool to screen for depression and suicidal ideation in TGD youth, especially those with severe acne. 36 Gender-affirming surgery may be pursued by certain TGD individuals if desired.…”

Section: Isotretinoinmentioning

confidence: 99%

Management of acne in transgender and gender diverse youth Part 2: Unique considerations and strategies in medical treatment

Hollingshead

Hodax

Boos

2022

Pediatric Dermatology

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Acne vulgaris is among the most common skin disorders afflicting adolescents worldwide, and though well-established guidelines of care exist for acne management, these guidelines do not uniformly consider or address the unique psychosocial and medical needs of transgender and gender diverse (TGD) youth. Part 2 of this two-part review provides guidance on a stepwise approach to the medical treatment of acne in TGD youth, with an emphasis on safety, efficacy, and the delivery of medical care in a culturally humble, thoughtful, and gender-affirming manner.

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“…Campos-Muñoz et al reported on treatment of severe acne in transgender boys, who are at high risk of depression. Two out of four boys (50%) developed severe depression after initiation of treatment ( Campos-Muñoz et al, 2020 ) Hannah et al reported on a series of nine cases referred for psychiatric hospitalization for depression following treatment with isotretinoin ( Karakula-Juchnowicz et al, 2016 )…”

Section: Case Reports and Clinical Series Of Depression Suicide Anxie...mentioning

confidence: 99%

Isotretinoin and neuropsychiatric side effects: Continued vigilance is needed

Bremner

2021

Journal of Affective Disorders Reports

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Depression in transgender adolescents under treatment with isotretinoin

Cited by 6 publications

References 5 publications

Treating Acne in Transgender Persons Receiving Testosterone: A Practical Guide

Treating Acne in Transgender Persons Receiving Testosterone: A Practical Guide

Management of acne in transgender and gender diverse youth Part 2: Unique considerations and strategies in medical treatment

Isotretinoin and neuropsychiatric side effects: Continued vigilance is needed

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