Depression, Insomnia, and Memory Loss in a Patient With Chronic Intoxication by Inorganic Mercury

Júnior, Quirino Cordeiro; Faria, Marcília de Araújo Medrado; Fráguas, Renério

doi:10.1176/jnp.15.4.457

Cited by 11 publications

(2 citation statements)

References 5 publications

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“…The current results recorded high the MCV, MCH, MCHC showed non-significant values It suggested that mercury chloride affects (number) red blood cells and white blood cells and hemoglobin but does not affect the (volume) corpuscular , all these result disagree with result of [26] who mentioned that the increase in MCV could be due to an increase of immature RBC from bone marrow, the increase of MCV has been observed in expos for methylmercury MeHg and explained By having a larger amount of old or large red blood cells [27,28]. The current results recorded decrease platelet showed non-significant values Suggested because of gastric infections caused by mercury chloride led to hemorrhage.…”

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confidence: 82%

Hematological evolution of anti-oxidative effects of Lipidum sativum in albino male rats

Hamad¹,

Ali²

2022

Magna Sci. Adv. Res. Rev.

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The current study aimed to investigate the anti-oxidative effects of Lipidum sativum agonist poisonous mercuric chloride. Total of 60 Swiss male rats were used which allocated into 5 groups; control group (C), mercuric chloride group (M), third, fourth and fifth groups were represented the treatment groups (T1, T2 & T3), each group was divide into two subgroups (21 and 42 days. The blood samples collection by heart puncture for Hematological study. Lepidium sativum extract seed was prepared in doses of 25, 50.100 mg/kg. Results showed in groups that treated with mercury chloride there was decrease in both periods (21 and 42) days in (WBC, RBC, HCT & Hb) and decrease in period of 21 days. In groups that treated with extract of seeds Lipidum sativum (100, 50, 25) mg / kg. showed increased in (WBC & RBC) in both periods. In (Hb) there was increase in the 21-days in (T3).In 42-day showed increase in (T2 & T3). In PVC there was increase in the 21-days. In the 42-day period showed increase all groups. Plate let showed increase at 42 days in treated group in (T1& T2). In MCV showed decrease in groups (T1, T2 & T3) at 21 days. In the 42-days showed a reduction in group (T1). The (MCHC) showed decrease in the 21 days and significant increase in (T2). The result concluded that the Lepidium sativum extract seed has improved the blood parameters against toxic effects of mercuric chloride in short and long term.

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confidence: 82%

Hematological evolution of anti-oxidative effects of Lipidum sativum in albino male rats

Hamad¹,

Ali²

2022

Magna Sci. Adv. Res. Rev.

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“…Recent scientific research has investigated the health benefits associated with Ocimum basilicum essential oils. Studies reveal the anti-viral, anti-microbial, antioxidant, and anti-cancer properties of the oils; further research is underway (Chiang et al, 2005;Bozin et al, 2006).…”

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confidence: 99%

Therapeutics potential of Ocimum basilicum following mercury chloride-induced hepatotoxicity in rats (Rattus norvegicus)

Adelakun¹,

Omotoso²,

Akingbade³

2018

Braz. J. Biol. Sci.

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Globally mercury (Hg) has been reported as one of heavy metal of known toxicity, noted for inducing public health disasters. Present study examines the therapeutics potentials of Ocimum basilicum on mercury chloride (HgCl2) induced hepatotoxicity in Wistar rats. Thirty adult Wistar rats randomly divided into six groups (A-F) of five rats each. Group A served as control was given 2 mL/day of distilled water, Group B, C, D, E and F received 500 mg/kg body weight (bwt) of O. basilicum extract, 20 mg/kg/bwt of HgCl2, 40 mg/kg bwt of HgCl2, 20 mg/kg bwt of HgCl2 and 500 mg/kg bwt O. basilicum leave extract, 40 mg/kg bwt and 500 mg/kg bwt O. basilicum administered daily by gastric gavage, for 21 consecutive days. The gross anatomical parameters of the liver and liver histology were assessed. Liver oxidative stress was evaluated by liver superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and malondialdehyde (MDA) assays. The activities of the biomarker enzymes of the liver (alanine transaminase, aspartate transaminase and alkaline phosphatase were assayed). Histological profiles of the liver revealed derangement of the liver cytoarchitecture following consumption of mercury chloride and a marked improvement was observed after O. basilicum administration. Similarly, O. basilicum improved the reduction of antioxidant parameters (SOD, CAT, GPx and GSH) and the increased MDA caused by mercury chloride consumption. O. basilicum thus proffer protection against free radical mediated oxidative stress in mercury chloride-induced hepatotoxicity in rats.

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Psychiatric and Mental Health Aspects of Neurotoxic Exposures

Narang¹,

Lippmann²

2009

Clinical Neurotoxicology

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Depression, Insomnia, and Memory Loss in a Patient With Chronic Intoxication by Inorganic Mercury

Cited by 11 publications

References 5 publications

Hematological evolution of anti-oxidative effects of Lipidum sativum in albino male rats

Hematological evolution of anti-oxidative effects of Lipidum sativum in albino male rats

Therapeutics potential of Ocimum basilicum following mercury chloride-induced hepatotoxicity in rats (Rattus norvegicus)

Psychiatric and Mental Health Aspects of Neurotoxic Exposures

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