Depression Is a Risk Factor for Noncompliance With Medical Treatment

DiMatteo, M. Robin; Lepper, Heidi S.; Croghan, Thomas W.

doi:10.1001/archinte.160.14.2101

Cited by 3,483 publications

(1,106 citation statements)

References 70 publications

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“…Consistent with the hypothesis, the results showed that higher levels of selfreported depressive symptoms were moderately associated with poorer GFD adherence. The present findings are comparable with research in other illnesses (e.g., diabetes) and varying treatment regimens (e.g., medication, diet and physical activity recommendations), where it has been found that depression acts as a barrier to good adherence (DiMatteo et al, 2000;Gonzalez et al, 2008;Grenard et al, 2011).…”

Section: Discussionsupporting

confidence: 89%

“…Meta-analyses conducted in other chronic illnesses (e.g., diabetes) have found significant associations between depression and non-adherence to medication and other treatment components (e.g., diet and physical activity recommendations; DiMatteo, Lepper, & Croghan, 2000;Gonzalez et al, 2008;Grenard et al, 2011), with depressed patients being 1.76-to-3 times less likely to adhere to medical treatment recommendations than non-depressed patients (DiMatteo et al, 2000;Grenard et al, 2011). Further, reduced treatment adherence is one mechanism via which the link between depression and many preventable chronic illnesses may be explained (Katon, 2011).…”

Section: Introductionmentioning

confidence: 99%

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The relationship between gluten free diet adherence and depressive symptoms in adults with coeliac disease: A systematic review with meta-analysis

Sainsbury

Marques

2018

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Conflicts of interest: none Funding: none 2The relationship between gluten free diet adherence and depressive symptoms in adults with coeliac disease: A systematic review with meta-analysis ABSTRACT Purpose: Depressive symptoms are common in patients with coeliac disease (CD) and may represent a barrier to gluten free diet (GFD) adherence. The aims of this meta-analysis were: (1) to synthesise the evidence on the relationship between depression or depressive symptoms and degree of adherence to a GFD in patients with CD who are already attempting a GFD (i.e., post-diagnosis and onset of GFD), and (2) to summarise the direction of causation of any observed relationship. Methods:A random effects meta-analysis of 8 cross-sectional studies (N=1644) was conducted.Included studies measured self-reported depressive symptoms and GFD adherence using either a dietitian interview or validated self-report questionnaire that considered unintentional gluten consumption.Results: There was a moderate association between poorer GFD adherence and greater depressive symptoms (r=0.398, 95% CI=0.321-0.469), with marked heterogeneity in the effects (I 2 =66.8%). A sensitivity analysis excluding studies with a moderate/high (k=1) or unclear risk of bias (k=1) did not change the results. Conclusion:The low number of studies meeting inclusion criteria limits the strength of the conclusions. Available evidence suggests there is an association between poorer GFD adherence and self-reported depressive symptoms; however, studies using longitudinal and prospective designs, and reliable measures, particularly for adherence, are needed to confirm this association. The direction of causation between depression and adherence remains unclear.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

The relationship between gluten free diet adherence and depressive symptoms in adults with coeliac disease: A systematic review with meta-analysis

Sainsbury

Marques

2018

Appetite

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“…Married people were easier to benefit from social support from their friends and family and displayed less distress and depression after the cancer diagnosis 30. Patients with depression displayed three times greater odds to be noncompliant with medical treatment recommendations compared with those who were not depressed 31. And a study in breast cancer demonstrated that women patients with depression were less likely to accept surgery 32.…”

Section: Discussionmentioning

confidence: 99%

Marital status and survival in patients with gastric cancer

et al. 2016

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The objective of this study is to examine the impact of marital status on incidence of metastasis at diagnosis, receipt of surgery, and cause‐specific survival (CSS) in patients with gastric cancer (GC). Research data is extracted from The Surveillance, Epidemiology, and End Results (SEER) database, and 18,196 patients diagnosed with GC from 2004 to 2010 are involved. Effects of marital status on incidence of metastasis at diagnosis, receipt of surgery, and CSS are determined using multivariable logistic regression and multivariable Cox regression models, as appropriate. Single GC patients have a higher incidence of metastasis at diagnosis than married patients, while the differences between divorced/separated patients or widowed patients and married patients are not significant. Among those without distant metastasis, single patients, divorced/separated patients, and widowed patients are much less likely to accept surgery compared with married patients. Finally, in the whole group of 18,196 GC patients, single patients, divorced/separated patients, and widowed patients have shorter CSS compared with married patients, even in each of the TNM stage. Marriage had a protective effect against undertreatment and cause‐specific mortality (CSM) in GC. Spousal support may contribute to higher rate of surgery receipt and better survival in patients with GC.

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“…This is consistent with observations in resourcerich settings (Boarts et al 2006;Gibbie et al 2007;Turner et al 2003;Villes et al 2007;Vranceanu et al 2008) and resource-limited settings Campos et al 2008;Pina Lopez et al 2008;Poupard et al 2007). In a meta-analysis of the effects of depression and anxiety on patient adherence, depressed patients had three times the odds of noncompliance compared to non-depressed patients (DiMatteo et al 2000). The observation that depression is inversely associated with adherence suggests that treatment of depression may improve adherence to medications (Dalessandro et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Antiretroviral Adherence in HIV+ Ugandan Parents and Their Children Initiating HAART in the MTCT-Plus Family Treatment Model: Role of Depression in Declining Adherence Over Time

et al. 2009

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We conducted a study to assess the effect of family-based treatment on adherence amongst HIV-infected parents and their HIV-infected children attending the Mother-To-Child-Transmission Plus program in Kampala, Uganda. Adherence was assessed using home-based pill counts and self-report. Mean adherence was over 94%. Depression was associated with incomplete adherence on multivariable analysis. Adherence declined over time. Qualitative interviews revealed lack of transportation money, stigma, clinical response to therapy, drug packaging, and cost of therapy may impact adherence. Our results indicate that providing ART to all eligible HIV-infected members in a household is associated with excellent adherence in both parents and children. Adherence to ART among new parents declines over time, even when patients receive treatment at no cost. Depression should be addressed as a potential barrier to adherence. Further study is necessary to assess the long-term impact of this family treatment model on adherence to ART in resource-limited settings.

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Depression Is a Risk Factor for Noncompliance With Medical Treatment

Cited by 3,483 publications

References 70 publications

The relationship between gluten free diet adherence and depressive symptoms in adults with coeliac disease: A systematic review with meta-analysis

The relationship between gluten free diet adherence and depressive symptoms in adults with coeliac disease: A systematic review with meta-analysis

Marital status and survival in patients with gastric cancer

Longitudinal Antiretroviral Adherence in HIV+ Ugandan Parents and Their Children Initiating HAART in the MTCT-Plus Family Treatment Model: Role of Depression in Declining Adherence Over Time

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