Depression is associated with an increase in the expression of the platelet adhesion receptor glycoprotein Ib

Baseline level of platelet-leukocyte aggregates, platelet CD63 expression, and soluble P-selectin concentration in patientswith posttraumatic stress disorder: A pilot study

“…Among various activation dependent markers studied, no elevation in baseline expression of platelet CD63 was found in depression (Walsh et al, 2002a;Lederbogen et al, 2004) or schizophrenia (Walsh et al, 2002b). Unexpectedly, CD63 negatively correlated with hyperarousal scores in our study.…”

Bioprofiling of platelets in medicated patients with depression

“…It has to be noted that for most platelet activation parameters evaluated in depression, there are also studies with non-significant results (i.e. describing no change) such as for β-TG (Kuijpers et al, 2002) or CD63 (Walsh et al, 2002). Despite the aforementioned limitations, we discuss below the findings of the current study in the context of the available literature.…”

“…Disruptions in serotonergic pathways can thus be linked to MDD but also to disturbances in platelet aggregation which underlies vascular disease (Pan et al, 2011;Ziegelstein et al, 2007) high amounts of peripheral serotonin (Liu et al, 2003) as well as serotonin receptors (5HT-R) and transporters similar to those found in the CNS (Barbui et al, 2002). Serotonin in CNS and platelets, as well as variations in its transporter and receptors, have been investigated in their relationship to depressive symptoms (Leo et al, 2006;Morel-Kopp et al, 2009;MullerOerlinghausen et al, 2004;Walsh et al, 2002). Several studies have also looked at the potential benefit of antidepressive treatment, namely serotonin reuptake inhibitors (SSRI), on CVD morbidity and mortality as well as parameters of platelet activation (von Kanel, 2004).…”

Whole blood serotonin and platelet activation in depressed post-myocardial infarction patients

“…Platelets are anuclear organelles bestowed with receptors, which are activated by a variety of factors such as damaged endothelium, dislipidaemia and circulating substances such as thromboxane and serotonin. As far as depression is concerned, increased platelet activation as compared to controls has been assessed by measuring plasma levels of platelet-specific release products such as platelet factor 4 (PF4) and h-thromboglobulin (hTG) (Musselman et al, 2000;Pollock et al, 2000), by measuring expression of procoagulant receptors on platelet membranes (Piletz et al, 2000;Walsh et al, 2002) and by measuring platelet aggregation (for review (Schins et al, 2003).…”