Depression is associated with increased incidence of osteoporotic thoracolumbar fracture in postmenopausal women: a prospective study

Zong, Yaqi; Tang, Yanming; Xue, Yuan; Ding, Huairong; Li, Zhiyang; He, Dong; Zhao, Ying; Wang, Pei

doi:10.1007/s00586-015-4033-8

Cited by 24 publications

(17 citation statements)

References 30 publications

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“…Feelings of guilt are associated with other depressive symptomatology, 50 while recent studies have associated depression with bone fracture risk and mental health. [51][52][53] Our BIA-ACC ® platform results of the MUS questionnaire confirmed the aforementioned studies and provided an easy, reliable screening test in postmenopausal women (supplementary information).…”

Section: Discussionsupporting

confidence: 77%

Bioimpedance analysis vs. DEXA as a screening tool for osteosarcopenia in lean, overweight and obese Caucasian postmenopausal females

Peppa

Stefanaki

Papaefstathiou

et al. 2017

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Section: Discussionsupporting

confidence: 77%

Bioimpedance analysis vs. DEXA as a screening tool for osteosarcopenia in lean, overweight and obese Caucasian postmenopausal females

Peppa

Stefanaki

Papaefstathiou

et al. 2017

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“…Previous studies have demonstrated a positive relationship between depressive disorders and a higher risk of vertebral fracture 18,20,21, but other research has reported different findings 19,22. However, our results support the notion that the risk of vertebral fracture is significantly higher in patients with a depressive disorder.…”

Section: Discussionsupporting

confidence: 64%

“…The long-term complications of vertebral fractures include kyphosis, deconditioning, insomnia, and depression 17. However, studies on the relationship between depressive disorders and the incidence of vertebral fracture have yielded conflicting results 18,19.…”

Section: Introductionmentioning

confidence: 99%

Risk of Vertebral Fracture in Patients Diagnosed with a Depressive Disorder: A Nationwide Population-Based Cohort Study

Lee¹,

Hu²,

Huang³

et al. 2017

Clinics

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OBJECTIVE:Previous studies have reported that depression may play a crucial role in the occurrence of vertebral fractures. However, a clear correlation between depressive disorders and osteoporotic fractures has not been established. We explored the association between depressive disorders and subsequent new-onset vertebral fractures. Additionally, we aimed to identify the potential risk factors for vertebral fracture in patients with a depressive disorder.METHODS:We studied patients listed in the Taiwan National Health Insurance Research Database who were diagnosed with a depressive disorder by a psychiatrist. The comparison cohort consisted of age- and sex-matched patients without a depressive disorder. The incidence rate and hazard ratios of subsequent vertebral fracture were evaluated. We used Cox regression analysis to evaluate the risk of vertebral fracture among patients with a depressive disorder.RESULTS:The total number of patients with and without a depressive disorder was 44,812. The incidence risk ratio (IRR) between these 2 cohorts indicated that depressive disorder patients had a higher risk of developing a subsequent vertebral fracture (IRR=1.41, 95% confidence interval [CI]=1.26–1.57, p<0.001). In the multivariate analysis, the depressive disorder cohort showed a higher risk of vertebral fracture than the comparison cohort (adjusted hazard ratio=1.24, 95% CI=1.11–1.38, p<0.001). Being older than 50 years, having a lower monthly income, and having hypertension, diabetes mellitus, cerebrovascular disease, chronic obstructive pulmonary disease, autoimmune disease, or osteoporosis were considered predictive factors for vertebral fracture in patients with depressive disorders.CONCLUSIONS:Depressive disorders may increase the risk of a subsequent new-onset vertebral fracture.

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“…There is a relationship between depression and locomotive disorder, osteoporosis, lumbar spinal stenosis, and fracture [29–31]. Endocrine factors such as depression-induced hypersecretion of corticotropin-releasing hormone and hypercortisolism, hypogonadism, growth hormone deficiency, and increased concentration of circulating interleukin 6 might play a crucial role in the bone loss observed in subjects suffering from major depression [29].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Locomotive Syndrome and Depression in Community-Dwelling Elderly People

Nakamura

Hashizume

Nomura

et al. 2017

Current Gerontology and Geriatrics Research

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Locomotive syndrome (LS) is a concept that refers to the condition of people requiring healthcare services because of problems associated with locomotion. Depression is a major psychiatric disease among the elderly, in addition to dementia. The purpose of this study was to determine the association between LS and depression. The study participants were 224 healthy elderly volunteers living in a rural area in Japan. LS was defined as scores ≥ 16 on the 25-question Geriatric Locomotive Function Scale (GLFS-25). Depression was defined as scores ≥ 5 on the 15-item Geriatric Depression Scale (GDS-15). Height and body weight were measured. The prevalence of LS and depression was 13.9% and 24.2%, respectively. Compared with the non-LS group, the LS group was older, was shorter, had a higher BMI, and had higher GDS-15 scores. Logistic regression analysis showed that participants with GDS-15 scores ≥ 6 had higher odds for LS than those with GDS-15 scores < 6 (odds ratio [OR] = 4.22). Conversely, the depression group had higher GLFS-25 scores than the nondepression group. Participants with GLFS-25 scores ≥ 5 had higher odds for depression than those with GLFS-25 scores < 5 (OR = 4.53). These findings suggest that there is a close relationship between LS and depression.

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Depression is associated with increased incidence of osteoporotic thoracolumbar fracture in postmenopausal women: a prospective study

Abstract: Depression is associated with a higher risk of thoracolumbar fracture, with more fracture pain and with lower quality of life in the 2 months following fracture.

Cited by 24 publications

References 30 publications

Bioimpedance analysis vs. DEXA as a screening tool for osteosarcopenia in lean, overweight and obese Caucasian postmenopausal females

Bioimpedance analysis vs. DEXA as a screening tool for osteosarcopenia in lean, overweight and obese Caucasian postmenopausal females

Risk of Vertebral Fracture in Patients Diagnosed with a Depressive Disorder: A Nationwide Population-Based Cohort Study

The Relationship between Locomotive Syndrome and Depression in Community-Dwelling Elderly People

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