Depression is differently associated with sleep measurement in obstructive sleep apnea, restless leg syndrome and periodic limb movement disorder

Lee, Tsung‐Han; Yen, Ting-Ting; Chiu, Nan‐Ying; Chang, Cheng-Chen; Hsu, Wen Yang; Chang, Yu-Jun; Chang, Ting‐Gang

doi:10.1016/j.psychres.2018.12.166

Cited by 20 publications

(11 citation statements)

References 50 publications

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“…RLS and depression often co-occur, and in our study, LMR was also found to be associated with depression [34][35][36]. In addition to the link between RLS and depression, depressed patients often experience periodic limb movement disorder (PLMD) [37,38]. Given previous research suggesting that the association between RLS and depression can be partially explained by sleep disturbance [33], we speculated and tested a model whereby insomnia mediates the association between LMR and depression.…”

Section: Restless Legs Syndrome/willis-ekbom Disease and Leg Motor Restlessnessmentioning

confidence: 61%

Association between leg motor restlessness and depression among Chinese males living at high-altitude: the mediating role of insomnia

et al. 2020

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Objective Previous research has documented an association between insomnia and depression among patients with restless legs syndrome (RLS)/Willis-Ekbom disease. Given that leg motor restlessness (LMR) is closely related to RLS, the purpose of this study was to investigate the prevalence of insomnia and depression among individuals with LMR. In addition, we examined the associations among LMR, insomnia, and depression in a sample of young Chinese men living in high-altitude areas. Methods Chinese military personnel working on the Qinghai Tibet Plateau (Lhasa, an altitude of 3600 m) were recruited in 2019 to complete a series of questionnaires. Participants having the urge to move their legs but not meeting the diagnostic criteria for RLS were classified as having LMR. Hierarchical linear regressions and mediational analyses using the SPSS PROCESS macro in SPSS were conducted to examine the associations among LMR, insomnia, and depression. Results Of 196 participants, 36 (18%) had LMR. Only 1 participant was diagnosed with RLS. The proportions of participants suffering from insomnia who had LMR and did not have LMR were 44% and 22%, respectively. For depression, the proportions were 47% and 28%, respectively. Results of the hierarchical linear regressions showed that both LMR and depression were associated with increased insomnia symptoms. In addition, results from the mediational analyses indicated that the indirect effect of LMR on depression was significant and accounted for 52% of the total effect. Conclusions Participants with LMR had a higher prevalence of insomnia and depression compared with those without LMR. In addition, LMR was correlated with depression, and insomnia played a significant role in this co-occurrence.

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Section: Restless Legs Syndrome/willis-ekbom Disease and Leg Motor Restlessnessmentioning

confidence: 61%

Association between leg motor restlessness and depression among Chinese males living at high-altitude: the mediating role of insomnia

et al. 2020

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“…It is possible that depression affects various parts of sleep. Recent polysomnography studies by Lee et al have found an association between depression and insomnia [24], and an association between depression and restless legs syndrome has also been found in other studies [25][26][27]. Depression has been shown to be a risk factor for excessive daytime sleepiness [28,29].…”

Section: Discussionmentioning

confidence: 81%

Risk factors for sleep disorders in patients undergoing peritoneal dialysis

Liu

Zhan

Zhao

et al. 2021

Sleep Biol. Rhythms

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Sleep disorders in patients with end-stage renal disease are common but have rarely been reported in previous studies. Therefore, we examined the prevalence of sleep disorders and the risk factors for declining sleep quality in patients undergoing peritoneal dialysis (PD). A multicenter prospective cohort study was conducted at five PD centers across different provinces in China. A total of 449 patients who underwent PD between March to November 2013 were enrolled. Demographic data, laboratory indicators, presence of depression, and sleep assessment data were collected. Sleep questionnaires reflecting five categories of sleep disorders, namely, insomnia, restless legs syndrome, excessive daytime sleepiness, possible narcolepsy, and sleepwalking and nightmares, were administered at baseline and at 24 months postoperatively. Sleep disorders were diagnosed when a patient had at least one sleep problem. At baseline, 335 (74.6%) patients had at least one type of sleep disorder. Depression, diabetes mellitus (DM), and male were found to be associated with the presence of a sleep disorder. At follow-up, the prevalence of insomnia, restless legs syndrome, and excessive daytime sleepiness had significantly increased in 285 patients. Furthermore, cardiovascular disease (CVD) was found to be associated with the presence of sleep disorders in patients with one or more disorders at baseline, whereas a low serum albumin level was found to be associated with sleep disorders in patients without any sleep disorders at baseline. The prevalence of sleep disorders was relatively high among PD patients at baseline and increased afterthe2-year follow-up. Depression, DM, and male were associated with all sleep disorders at baseline. CVD was associated with the presence of a sleep disorder at baseline and worse sleep quality at the 2-year follow-up; whereas a low serum albumin level was associated with the risk of acquiring a sleep disorder at the 2-year follow-up among patients with normal sleep status at baseline.

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“…Ta èiau dau ge lis ty ri mø tei gia esant stipriam ry ðiui tarp dep re si jos ir ne ra miø ko jø sin dro mo. Vieni ty rë jai tei gia, kad ser gan tie ji dep re si ja daug daþ niau serga NKS [12]. Ki tø stu di jø me tu ras ta, kad dep re si jos sunku mas ser gan tie siems NKS ko re liuo ja su ne mi gos stip rumu [13].…”

Section: Rezultatø Aptarimasunclassified

“…Mû sø duo me ni mis, NKS pa cien tai sta tis tið kai reikðmin gai blo giau ver ti no sa vo svei ka tos bûk lae nei kon tro linës gru pës ti ria mie ji, o SF-36 svei ka tos bûk lës áver tis blogë jo sun kë jant NKS simp to mø nað tai. Ry ðá tarp NKS sunku mo ir gy ve ni mo ko ky bës ver ti ni mo bei afek ti niø su tri kimø nu sta të ir ki ti ty ri mai [12]. Svar bu yra tai, kad ras ta vidu ti nio stip ru mo ne igia ma ko re lia ci ja tarp TNKS ska lës ba lø ir skaus mo ver ti ni mo, t. y., sun kë jant NKS simp to mø nað tai, di dë ja ir skaus mo su ke lia mas dis kom for tas.…”

Section: Rezultatø Aptarimasunclassified

Psychosocial, physical, cognitive and quality of life aspects in primary restless legs syndrome

Jarašiūnaitė¹,

Kaladytė-Lokominienė²

2019

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Įvadas. Neramių kojų sindromas (NKS) yra lėtinis neurologinis sutrikimas, pasireiškiantis nemaloniais pojūčiais kojose ar (ir) kitose kūno dalyse bei nenumaldomu noru judėti, kad sumažėtų jutiminis diskomfortas. Šis sindromas paveikia 5-15 % populiacijos visame pasaulyje. NKS turi didelės įtakos gyvenimo kokybei. Sindromui būdingas sutrikdytas nakties miegas ir mieguistumas dieną. Atlikta nemažai tyrimų dėl NKS sąsajų su pažintinių funkcijų blogėjimu, tačiau jų rezultatai yra skirtingi. Tiriamieji ir tyrimo metodai. 2019 m. sausio-kovo mėnesiais Vilniaus universiteto ligoninės Santaros klinikų Neurologijos centre atliktame tyrime dalyvavo 19 sergančiųjų pirminiu NKS ir 20 pagal amžių, išsilavinimą, lytį atrinktų NKS neturinčių kontrolinės grupės asmenų. Tyrimo dalyviams pateikta anketa su tarptautine NKS vertinimo skale TNKS, demografiniais duomenimis, gyvenimo kokybės vertinimo klausimynu SF-36, ligoninei pritaikyta depresijos ir nerimo skale HADS, pažinimo funkcijų vertinimo testu MoCA, Epworth mieguistumo dieną ir nuovargio klausimynais. NKS grupės tyrimo dalyvių judėjimo greitis įvertintas terminuoto atsistojimo ir 10 metrų ėjimo testu TUG. Statistinė analizė atlikta SPSS 23.0 programa, naudota Pearson koreliacija, chi² testas, dviejų imčių t-testas. Duomenys laikyti statistiškai reikšmingais, kai p < 0,05. Rezultatai. Tyrime dalyvavo 39 asmenys (32 moterys), kurių amžius – 65,1 ± 11,3 m. Statistiškai reikšmingai skyrėsi asmenų su NKS ir kontrolinės grupės tiriamųjų bendras MoCA rezultatas (p = 0,007), dėmesio (p = 0,002) ir ilgalaikio atgaminimo (p = 0,005) įverčiai. NKS grupės SF-36 klausimyno sveikatos būklės įvertis buvo mažesnis nei kontrolinės grupės asmenų (p = 0,032). Nustatyta vidutinio stiprumo neigiama koreliacija tarp TNKS skalės balų sumos ir skausmo (p < 0,001, r = -0,694) bei sveikatos būklės įverčių (p = 0,009, r = -0,585). TUG testo metu išmatuotas laikas su TNKS skalės balais nekoreliavo (p = 0,523, r = 0,156). Statistiškai reikšmingai nesiskyrė NKS ir kontrolinės grupių HADS depresijos ir nerimo rezultatai (p = 0,282 ir p = 0,219) bei mieguistumo ir nuovargio įverčiai (p = 0,141 ir p = 0,109, atitinkamai). Išvados. NKS pasireiškimo sunkumas turi ryšį su pacientų gyvenimo kokybės blogėjimu (pagal skausmo ir sveikatos būklės vertinimą). NKS nesusijęs su aukštesniais depresiškumo ir nerimastingumo įverčiais. Judėjimo greičio vertinimo rezultatai nėra susiję su NKS sunkumu. Sergančiųjų NKS pažinimo funkcijų įverčiai yra blogesni nei kontrolinėje grupėje.

show abstract

Depression is differently associated with sleep measurement in obstructive sleep apnea, restless leg syndrome and periodic limb movement disorder

Cited by 20 publications

References 50 publications

Association between leg motor restlessness and depression among Chinese males living at high-altitude: the mediating role of insomnia

Association between leg motor restlessness and depression among Chinese males living at high-altitude: the mediating role of insomnia

Risk factors for sleep disorders in patients undergoing peritoneal dialysis

Psychosocial, physical, cognitive and quality of life aspects in primary restless legs syndrome

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