Depression of cytochrome P450-dependent drug biotransformation by poly(rI·rC) and aspirin

Isozyme‐specific induction of low‐dose aspirin on cytochrome P450 in healthy subjects

“…[6][7][8] Our interest in acetylsalicylic acid was aroused by reported effects of acetylsalicylic acid or salicylate on CYP activity (in particular, CYP2E1) when used in relatively high doses. [9][10][11][12][13] However, no data are available as to the effect of aspirin or salicylate on CYP activity in humans. Because of the frequent use of low-dose aspirin, it is of interest to determine whether low-dose aspirin administration modulates activities of CYP isozymes in vivo in humans.…”