Depression risk in patients with heart failure in primary care practices in Germany

Konrad, Marcel; Bohlken, Jens; Rapp, Michael A.; Kostev, Karel

doi:10.1017/s1041610216000867

Cited by 11 publications

(8 citation statements)

References 26 publications

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“… 9 Rathmann et al demonstrated good agreement between the outpatient DA database with German reference data with respect to the incidence or prevalence of cancer diagnoses. 9 Finally, this database has already been used in previous studies focusing on cardiovascular disorders 10 , 11 as well as cancer. 12 , 13 …”

Section: Methodsmentioning

confidence: 99%

Pulmonary hypertension is associated with an increased incidence of cancer diagnoses

et al. 2022

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Pulmonary hypertension (PH) is a complex disease with increasing global incidence that eventually leads to right ventricular failure and is associated with a poor prognosis. The importance of noncardiac comorbidities in disease progression and prognosis has gained increasing recognition in recent years.In the present study, we investigated a potential association between PH and cancer in an outpatient cohort in Germany. Using the IQVIA Disease Analyzer database, we identified a total of 11,109 patients with PH and a propensity score matched cohort of equal size without PH who received medical treatment between 2005 and 2019. Logistic regression models were used to evaluate the potential association between PH and cancer. Within the 10-year observation period, the incidence of cancer was significantly higher in PH patients than non-PH patients (23.2% vs. 8.5%, log-rank p < 0.001). Importantly, this association was observed for both male (HR = 1.24, p = 0.002) and female (HR = 1.37, p < 0.001) patients, and was most pronounced in patients >80 years (HR = 1.50, p < 0.001). In terms of a specific tumor site, we found a significant association for respiratory organ cancer (HR = 1.60, p = 0.007) and skin cancer (HR = 1.48, p < 0.001). Our study provides strong evidence that PH is associated with an increased incidence of cancer. This finding should help raise awareness of this important comorbidity and could trigger specific screening programs in patients with PH.

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Section: Methodsmentioning

confidence: 99%

Pulmonary hypertension is associated with an increased incidence of cancer diagnoses

et al. 2022

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“…D epression is a prevalent psychiatric comorbidity in heart failure (HF) (1)(2)(3)(4)(5). Multiple studies have identified factors that are associated with comorbid depression in HF.…”

Section: Introductionmentioning

confidence: 99%

Left Ventricular Dysfunction and Depression in Hospitalized Patients with Heart Failure

et al. 2021

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Objective: This study examined whether the severity of left ventricular systolic dysfunction is associated with depression in patients with heart failure (HF). Other factors were also studied to identify independent correlates of depression in HF. Methods: The sample consisted of 400 hospitalized patients with HF. Left ventricular ejection fraction and other medical data were obtained from medical records. Depression and other psychosocial characteristics were assessed by an interview and questionnaires. Proportional odds models were used to test the relationships of these characteristics to Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) depressive disorders, and analysis of covariance was used to test relationships with continuous measures of depression in secondary models. Results: The models produced no evidence of an association between left ventricular ejection fraction and depression. The adjusted odds ratio (95% confidence interval) was 1.00 (0.98-1.01; p = .87) for depression diagnosis. Analysis of covariance estimates (standard errors) were −0.01 (0.02; p = .54) for the Hamilton Rating Scale for Depression and −0.01 (0.01; p = .59) for the Patient Health Questionnaire. The odds of depression were higher in African American patients and in those with high levels of anxiety or stress. Other characteristics that have been associated with depression in previous studies, including sex and age, were not consistently associated with depression in this study. Conclusions: There is no relationship between the severity of left ventricular systolic dysfunction and depression in hospitalized patients with HF. In contrast, African American patients and those with a high level of anxiety or perceived stress are more likely than other patients to have a comorbid depressive disorder.

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“…As a matter of fact, a 2010 meta-analysis estimated that current smoking status, higher body mass index, history of cardiovascular disease, hypertension, diabetes, history of cerebrovascular disease, and serum total and HDL cholesterol and triglyceride levels, were all risk factors for the diagnosis of AMD [ 17 ]. Interestingly, several of these risk factors were recently found to increase the odds of developing depression and anxiety in Germany [ 18 ], [ 19 ], [ 20 ]. As a result, it is possible that individuals with AMD are depressed not only because of the impairment of their visual acuity but also because of the impact of their other medical conditions on their daily lives.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of depression, anxiety, adjustment disorders, and somatoform disorders in patients with age-related macular degeneration in Germany

Jacob

Spiess²,

Kostev³

2017

GMS German Medical Science; 15:Doc04

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Depression risk in patients with heart failure in primary care practices in Germany

Abstract: The risk of diagnosed depression is significantly increased in patients with HF compared to patients without HF in primary care practices in Germany.

Cited by 11 publications

References 26 publications

Pulmonary hypertension is associated with an increased incidence of cancer diagnoses

Pulmonary hypertension is associated with an increased incidence of cancer diagnoses

Left Ventricular Dysfunction and Depression in Hospitalized Patients with Heart Failure

Prevalence of depression, anxiety, adjustment disorders, and somatoform disorders in patients with age-related macular degeneration in Germany

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