Depression scores change significantly after omalizumab treatment in patients with chronic spontaneous urticaria

Can, Pelin Kuteyla; Etikan, Piril; Değirmentepe, Ece Nur; Kocatürk, Emek

doi:10.12932/ap-180920-0965

Cited by 3 publications

(2 citation statements)

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“…16 Yine omalizumab tedavisinin anksiyete ve depresyon belirtilerini gerilettiği ve hatta iyileştirdiğine dair yayınlar mevcuttur. 17,18 Sunulan çalışmada, hastaların tedavi öncesi anksiyete depresyon düzeylerinin tedavinin altıncı ayında anlamlı derecede düzeldiği gösterilmiştir. Bu iyileşme KSÜ belirtilerinin iyileşmesinin verdiği psikolojik rahatlama ile ilişkili olabileceği gibi anksiyete ve depresyon ile ilgili otoimmün sürece müdahale de söz konusu olabilir.…”

Section: Discussionunclassified

Dermatological Recovery in Chronic Spontaneous Urticaria Patients Also Improves Sexual Functioning and Intrinsic Stigma: A 6-Month Follow-Up Study

ÖZTAŞ KARA,

YAZICI,

KARACA

et al. 2023

Turkiye Klinikleri J Dermatol

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Ölçeği puanları ve bu envanterin alt başlıklarından; uyarılma, orgazm ve ağrı parametrelerinin tedavi sonrası istatistiksel anlamlılık oluşturacak şekilde düzeldiği tespit edildi (p<0,05). Cinsel istek alt parametresinde ise istatistiksel anlamlılık oluşturacak şekilde olumsuz yönde değişim görüldü (p<0,05). Benzer şekilde Ürtikerde İçselleştirilmiş Damgalanması Ölçeği ve alt başlığı damgalanmaya direnç parametresinde, Kronik Ürtiker Yaşam Kalitesi İndeksi, Beck Anksiyete Envanteri ve Beck Depresyon Envanteri'nde tedavi sonrasında anlamlı iyileşme saptandı. Hastalık süresi değişkeninin tedavi öncesi Kadın Cinsel Fonksiyon İndeksi toplam skoru ile alt skorlarından; lubrikasyon, orgazm, ağrı ve doyum alt başlıkları ile negatif yönde korelasyon, Rosenberg Benlik Saygısı Ölçeği ile arasında pozitif yönde korelasyon gösterdiği tespit edildi. Kadın Cinsel Fonksiyon İndeksi ile Beck Anksiyete Envanteri ile arasında istatistiksel anlamlı negatif korelasyon olduğu görüldü. Hastaların yaş değişkeninin tedavi öncesi kadın cinsel fonksiyon indeksi toplam skoru ve alt başlıkları ile negatif yönde korelasyon gösterdiği tespit edildi. Sonuç: Sonuç olarak, kronik spontan ürtiker hastalarında sadece dermatolojik yönden hastalık şiddetinin değerlendirilmesi ve tedavisinin yanı sıra, cinsel yaşam gibi belirli psikososyal sorunları da dikkate almak gerektiği ortaya konmuştur. Anah tar Ke li me ler: Ürtiker; depresyon; anksiyete; yaşam kalitesi; seksüel sağlık ABS TRACT Objective: Our study aimed to investigate the effect of chronic spontaneous urticaria on sexual health and functioning, depression, anxiety, self-esteem, quality of life, and internalized stigma in female patients. Material and Methods: In the present study, Beck

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Section: Discussionunclassified

Dermatological Recovery in Chronic Spontaneous Urticaria Patients Also Improves Sexual Functioning and Intrinsic Stigma: A 6-Month Follow-Up Study

ÖZTAŞ KARA,

YAZICI,

KARACA

et al. 2023

Turkiye Klinikleri J Dermatol

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“…17 In a study in which 40 patients participated in the study, which aimed to measure depressive symptoms in CSU patients who received at least 3 doses of omalizumab, it was stated that the use of omalizumab not only regressed the symptoms of urticaria, but also improved the psychological conditions of the patients. 18 Benefits of omalizumab on anxiety and depression in patients with severe asthma were investigated by Turkish researchers before. 19 The authors studied with 20 severe asthma patients that all of whom received omalizumab treatment (mean treatment duration was stated 17.6 months).…”

Section: Discussionmentioning

confidence: 99%

Does omalizumab use in chronic spontaneous urticaria results in improvement in sexual functions?

Durmaz¹,

Ataseven

Temiz

et al. 2022

J of Cosmetic Dermatology

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Background Chronic spontaneous urticaria (CSU) is a disease that can affect the patient's quality of life (QoL), sexual functions, and mood. Objective We planned a retrospective study to investigate the effects of omalizumab use in CSU patients on sexual function. We also aimed to evaluate the sexual function, quality of life (QoL), and mood of CSU patients compared to the control group consisting of idiopathic pruritus patients. Methods A review of patients’ records with CSU attending the dermatology outpatient clinic from January 2020 to June 2020 was done. Urticaria activation score (UAS7), Beck depression inventory (BDI), Dermatology life quality index (DLQI), female sexual function index (FSFI) to female participants, and the international index of erectile function (IIEF) to male participants were used to assess the impact of the disease on patients’ life. The obtained data were analyzed by using SPSS software. Results Each one of the mean UAS, BDI, and DLQI score values decreased significantly in weeks in omalizumab group patients. IIEF score in male patients and FSFI score in female patients also increased in weeks in omalizumab group patients. Conclusions Omalizumab can play an effective role in enhancing the sexual function of CSU patients in addition to improving their DLQI.

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Long term treatment with omalizumab in adolescent with refractory solar urticaria

et al. 2021

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Background Solar urticaria represents an uncomfortable form of chronic inducible urticaria. First and second-line treatments are ineffective in some patients, leading to an impairment in their quality of life. Omalizumab represents a safe therapeutic option in case of refractory solar urticaria. Case presentation We update a case of a 21-year-old Caucasian girl affected by solar urticaria from the age of 14. Poor disease control was achieved with standard or high-dose of H1-antihistamines. Several omalizumab courses, including a 1-year-long course, were practiced resulting in clinical remission and significant improvement in patient’s quality of life. Conclusion Our experience confirms the effectiveness and safety of omalizumab for the management of refractory solar urticaria. Future studies are awaited in order to monitor long term effects and chronic doses of this treatment, particularly in patients who need concomitant therapy with antihistamines.

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Depression scores change significantly after omalizumab treatment in patients with chronic spontaneous urticaria

Cited by 3 publications

References 0 publications

Dermatological Recovery in Chronic Spontaneous Urticaria Patients Also Improves Sexual Functioning and Intrinsic Stigma: A 6-Month Follow-Up Study

Dermatological Recovery in Chronic Spontaneous Urticaria Patients Also Improves Sexual Functioning and Intrinsic Stigma: A 6-Month Follow-Up Study

Does omalizumab use in chronic spontaneous urticaria results in improvement in sexual functions?

Long term treatment with omalizumab in adolescent with refractory solar urticaria

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