“…The relationship between SCD and psychological impact has also been widely investigated (Anie, 2005;Burlew, Telfair, Colangelo, & Wright, 2000;Edwards et al, 2009;Harris et al, 1998;Hilton, Osborn, Knight, Singhal, & Serjeant, 1997;Schaeffer et al, 1999;Thompson, Gil, Abrams, & Phillips, 1992). For example, Anie (2005) explored the common psychological complications associated with sickle cell disease including anxiety, depression, neurocognitive impairment, ineffective pain coping mechanism, low quality of life, aggression, social isolation and poor relationships, and low school performance.…”