Depression, Symptoms and the Quality of Life in Patients on Hemodialysis for End-Stage Renal Disease

Abstract

Background: End-stage renal disease (ESRD) is a progressive, debilitating, chronic illness requiring nursing and medical interventions. The goal of this study was to explore the level of depression experienced by patients receiving hemodialysis (n = 146), and to compare the symptoms with the quality of life (QoL) between patients that were depressed and those that were not depressed. Methods: For this descriptive, cross-sectional survey, participants aged 18 and above were recruited from three different regions in the Republic of Korea. The level of depression, symptoms and QoL of the participants were measured by questionnaires from October to December 2006. The data was analyzed with descriptive statistics, the χ² and t test using the SPSS WIN 14.0 program. Results: The prevalence of depression (PHQ-9) among the participants was 25.34%. There were more symptoms reported in the depressed group of patients than in those that were not depressed. In addition, the QoL was not as good in the depressed group when compared to patients that were not depressed. Conclusion: Therefore, the evaluation for depression may be an important part of the management of patients with ESRD. Further research is needed to understand the causal relationship between depression and health outcomes.

Symptom Burden, Depression, and Quality of Life in Chronic and End-Stage Kidney Disease

“…The severity of depressive disorder is considered moderate for scores ranging from 10 to 14, moderately severe for scores of 15 to 19, and severe for scores of 20 to 27. The PHQ-9 has been used to assess depression in patients with ESRD and those with CKD (25)(26)(27). In patients on hemodialysis, scores Ͼ9 are 92% sensitive and specific for a diagnosis of depressive disorder (25).…”

The Psychological Impact of Hemodialysis on Patients with Chronic Renal Failure

“…The QoL domains include physical, psychological, and social functioning and general satisfaction with life (Tsay & Healstead, 2002). Once patients with ESRD start to receive HD, they must face the chronic stress related to restrictions on their time, the economical and vocational costs related to treatment, functional limitations, dietary constraints, and possible adverse effects of medications (Son et al, 2009). Numerous studies have demonstrated that these patients have a lower QoL than that of healthy populations (Kao et al, 2009;Perlman et al, 2005;Wolcott et al, 1988).…”

“…More than 90% of these patients were started on hemodialysis (HD), while only 8.5% began RRT with peritoneal dialysis (PD) (Kimmel & Peterson, 2005). In Korea, the number of dialysis centers and machines has continuously increased, and 62.1% of patients receiving RRT were being treated with HD (Son et al, 2009). An international comparison showed that Taiwan has the greatest incidence and second-greatest prevalence of ESRD (Kuo et al, 2007).…”

The role of adipocytokines on depressive symptoms of patients with chronic kidney disease

“…44 The etiology of depressive disorders in CKD patients is multiple, including psychological, physical and socioeconomic state. Leptin, adiponectin, neuropeptide Y, ghrelin and resistin were reported to be involved in pathophysiology of depressive disorders among subjects with normal kidney function.…”