Depression, Testosterone Concentration, Sexual Dysfunction and Methadone Use Among Men with Hypogonadism and HIV Infection

Lari, Mahmood Amini; Parsa, Nader; Marzban, Maryam; Shams, Mesbah; Faramarzi, Hossein

doi:10.1007/s10461-012-0234-x

Cited by 21 publications

(10 citation statements)

References 30 publications

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“…However, the findings contrast with an earlier study in Iran that reported a considerably higher rate (68%) (4). We suggest that the inconsistent use of antivirals and simultaneous treatment with methadone in that study contributed to higher rates.…”

Section: Discussioncontrasting

confidence: 99%

“…Major depressive disorders have been reported among 10.2% of the Iranian men, while moderate to severe depressions have been documented among 68.8% of the people living with HIV (PLWH) (3,4). Disease stage, co-morbid psychiatric disorders, deranged social/family functioning, and unfavorable immunologic response to ART are known attributes of the higher prevalence of depression in the PLWH.…”

Section: Introductionmentioning

confidence: 99%

“…A recent study indicates hypogonadism, thyroid disease, and adrenal dysfunction as common disorders among ARTnaive patients (10). Gonadal dysfunction is frequently observed (25% to 68%) even among the patients whose viral replication is undetectable, while depression may be their only presenting symptom (4,5,(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

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Depression Improvement Among Patients with HIV and Endocrine Dysfunction After hormone Therapy

Ghiasvand

Rahimi-Movaghar

Esteghamati

et al. 2017

Iran Red Crescent Med J

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Endocrine diseases, known as a curable etiology for depression, are common among men living with HIV (MLWH); while depression impedes the adherence to treatment and the perceived quality of life. We evaluated the changes in the depressive symptoms after the medical treatment of the underlying endocrine diseases among Iranian MLWH. Since April 2013 to March 2014, a convenience sample of 296 MLWH was recruited. We interviewed all the patients using the beck depression inventory (BDI-II) questionnaire.Participants with moderate to severe depression (n = 110, scores ≥ 21) were evaluated for endocrine diseases (evaluations: total testosterone, triiodothyronine, thyroxine, thyroid stimulating hormone, luteinizing hormone, follicle stimulating hormone, and serum cortisol). Eleven patients diagnosed with hypogonadism were, finally, considered for hormone replacement therapy. We re-evaluated the changes in the depressive symptoms with BDI-II. Out of 237 participants, 136 (75%) had BDI scores ≥ 21; 110 participated in the endocrine evaluations. Secondary hypogonadism was the only observed abnormality in 10% (n = 11) of the patients. Significant improvements were observed in BDI-II scores after 3 months of treatment (P = 0.027). The evaluation and the treatment of hypogonadism can help clinicians to properly address depression among people living with HIV; hence, improve the treatment compliance and the patient outcomes.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Depression Improvement Among Patients with HIV and Endocrine Dysfunction After hormone Therapy

Ghiasvand

Rahimi-Movaghar

Esteghamati

et al. 2017

Iran Red Crescent Med J

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“…Many other authors have found increased estradiol levels [ 33 ]; however, the review by Collazos implies no relationship between high estrogen levels and ED [ 6 ]. Amini et al found statistically significant differences in the erectile function domain between eugonadal and hypogonadal patients [ 34 ]; while other studies failed to demonstrate this association [ 13 , 20 ]. Another limitation of the present study is that the use of phosphodiesterase 5 inhibitors and that of statins were not evaluated.…”

Section: Discussionmentioning

confidence: 99%

Erectile Dysfunction Among HIV Patients Undergoing Highly Active Antiretroviral Therapy: Dyslipidemia as a Main Risk Factor

et al. 2014

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ObjectiveTo assess the prevalence and risk factors of erectile dysfunction (ED) in HIV patients from the HIV clinic of a tertiary referral center in Mexico City.DesignPrevalence was obtained from cross-sectional studies, and the International Index of Erectile Function (IIEF), a standardized method, was used to assess ED.MethodsA cross-sectional study was performed in the HIV clinic. Participants completed the IIEF to allow ED assessment. Information on demographics, clinical and HIV-related variables was retrieved from their medical records.ResultsOne hundred and nine patients were included, with a mean age of 39.9 ± 8.8 years. ED was present in 65.1% of the individuals. Patients had been diagnosed with HIV for a mean of 92.7 ± 70.3 months and had undergone a mean 56.4 ± 45.5 months of HAART. The only variable associated with ED in the univariate analysis was dyslipidemia, and this association was also found in the multivariate analysis (P = 0.01).ConclusionsED is highly prevalent in HIV patients. Dyslipidemia should be considered as a risk factor for ED in HIV patients. Romero-Velez G, Lisker-Cervantes A, Villeda-Sandoval CI, Sotomayor de Zavaleta M, Olvera-Posada D, Sierra-Madero JG, Arreguin-Camacho LO, and Castillejos-Molina RA. Erectile dysfunction among HIV patients undergoing highly active antiretroviral therapy: Dyslipidemia as a main risk factor. Sex Med 2014;2:24–30.

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“…Psychological and psychosexual issues may not to be underestimated as contributors to ED, especially in HIV setting [14,70,72,152]. Thoughtful discussion of these issues with men and their partners is a key component of patient education and can promote acceptance of incorporating a mental health/sexuality expert into the therapeutic plan.…”

Section: Pharmacological Treatmentmentioning

confidence: 99%

HIV and Sexual Dysfunction in Men

Vincentis

Tartaro

Rochira

et al. 2021

JCM

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Sexual issues tend to go unaddressed in human immunodeficiency virus (HIV) management, although overt sexual dysfunctions are more prevalent in people living with HIV than uninfected people. Erectile dysfunction is the most frequent sexual problem, with a prevalence of 30–50% even in men <40 years of age, but other issues such as loss of libido and ejaculatory disorders should not be overlooked. Peculiar factors related to HIV infection (e.g., fear of virus transmission, changes in body image, HIV-related comorbidities, HIV distress and stigma), alongside classical factors non-related to HIV, should be considered when approaching sexual problems in HIV patients. For this reason, the diagnostic and therapeutic workout of sexual dysfunction in the context of HIV requires a multidisciplinary approach, involving specialists in both infectious diseases and sexual medicine. This narrative review presents an overview of current knowledge on sexual dysfunction in HIV men, deepening the factors driving and taking part in these issues, providing advice for the clinical approach, and underlining the importance of caring for sexual health to improve the quality of life of HIV patients.

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Depression, Testosterone Concentration, Sexual Dysfunction and Methadone Use Among Men with Hypogonadism and HIV Infection

Cited by 21 publications

References 30 publications

Depression Improvement Among Patients with HIV and Endocrine Dysfunction After hormone Therapy

Depression Improvement Among Patients with HIV and Endocrine Dysfunction After hormone Therapy

Erectile Dysfunction Among HIV Patients Undergoing Highly Active Antiretroviral Therapy: Dyslipidemia as a Main Risk Factor

HIV and Sexual Dysfunction in Men

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