Depressive and anxiety disorders and risk of subclinical atherosclerosis

Seldenrijk, Adrie; Vogelzangs, Nicole; Hout, Hein van; Marwijk, Harm van; Diamant, Michaëla; Penninx, Brenda W. J. H.

doi:10.1016/j.jpsychores.2010.01.005

Cited by 42 publications

(16 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In humans, a randomized clinical trial demonstrated that patients with congestive heart failure taking sertraline, an SSRI, had a reduction in the expression of cell endothelial adhesion molecules (VCAM and ICAM) after a 3 month exposure compared to patients receiving placebo indicating a possible anti-inflammatory effect 46 . On the other hand, a cross-sectional population study from the Netherlands found no association between SSRIs, TCAs or “other” antidepressants with measures of ABI 44 . Our longitudinal study further complements the literature by demonstrating a null relationship between SSRIs, SNRIs, TCAs and “other” antidepressants not only with measures of ABI, but also measures of CAC and cIMT over a 10-year observational period.…”

Section: Discussionmentioning

confidence: 91%

“…In this study we controlled for symptoms of depression and anxiety, yet the scales that were used (CES-D and STAI) are not frequently used in clinical practice and participants in the MESA cohort were not assessed with structure clinical interviews to discern a diagnosis of a major depressive or anxiety disorder. Even though, cross-sectional studies have demonstrated an association between depressive and anxiety disorders with subclinical atherosclerosis as measured by the ABI 44 , our manuscript was not intended to study the association of depressive symptoms with subclinical measures of atherosclerosis. To what extent the use of antidepressants might protect against the development of atherosclerosis remains to be further examined.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antidepressant Use and Subclinical Measures of Atherosclerosis

Camacho¹,

McClelland²,

Delaney³

et al. 2016

J Clin Psychopharmacol

View full text Add to dashboard Cite

Background Antidepressants are commonly prescribed medications used in primary care. The cardiovascular safety profile of anti-depressant medications, in terms of subclinical atherosclerosis, is under-examined. Methods 6,814 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) were examined. At baseline, the mean age was 62 years with four race/ethnic groups represented: European-(38%), Hispanic-(23%), African-(28%) and Chinese-Americans (11%). Antidepressants were sub-grouped as serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and “other” (bupropion, nefazodone, trazodone, mirtazapine). After adjusting for potential confounders, we estimated the association between antidepressant use and the following measures of subclinical atherosclerosis: coronary artery calcium (CAC), the ankle-brachial index (ABI), and carotid intima-media thickness (cIMT), both cross-sectionally and prospectively. Results A total of 324 participants were exposed to SSRIs, 88 to TCAs, 41 to SNRIs and 123 to “other” antidepressants. For CAC incidence, the fully-adjusted longitudinal analyses revealed no consistent associations with SSRIs[RR: 0.99(0.71, 1.37)], SNRIs[RR=0.49(0.13, 1.86)], TCAs[RR=0.94(0.50, 1.77)], other antidepressant [RR=0.87(0.73, 1.03)] exposure and subclinical disease. Similar null results were obtained in the cross-sectional and longitudinal exposure to antidepressants with changes in baseline CAC>0, ABI and cIMT. Conclusions The results of the current study do not support an association between antidepressants and subclinical atherosclerosis.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Antidepressant Use and Subclinical Measures of Atherosclerosis

Camacho¹,

McClelland²,

Delaney³

et al. 2016

J Clin Psychopharmacol

View full text Add to dashboard Cite

show abstract

“…Several have reported a positive association between subclinical atherosclerosis and the psychological attributes of depression (Agatisa et al, 2005; Janssen et al, 2011; Lewis et al, 2009; Tiemeier et al, 2004), anxiety (Paterniti et al, 2001; Seldenrijk et al, 2010), and stress (Troxel et al, 2003), while others document null findings (Low et al, 2011; Low et al, 2009; Matthews et al, 1998; O’Malley et al, 2000a; Ohira et al, 2012; Roux et al, 2006; Rozanski et al, 2011; Seldenrijk et al, 2011; Stewart et al, 2007; Yu et al, 2010). Select evidence indicates up to a three-fold higher risk for atherosclerosis among those with psychological ill-being (e.g., major depression) (Agatisa et al, 2005; Paterniti et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Association of depressive symptoms, trait anxiety, and perceived stress with subclinical atherosclerosis: Results from the Chicago Healthy Aging Study (CHAS)

Hernandez

Allen²,

Liu³

et al. 2014

Preventive Medicine

View full text Add to dashboard Cite

Objective Examine the association between multiple psychological factors (depressive symptoms, trait anxiety, perceived stress) and subclinical atherosclerosis in older age. Method This cross-sectional study included 1,101 adults ages 65-84 from the Chicago Healthy Aging Study (CHAS—2007-2010). Previously validated self-report instruments were used to assess psychological factors. Noninvasive methods were used to assess subclinical atherosclerosis in two regions of the body, i.e., ankle-brachial blood pressure index (ABI) and coronary artery calcification (CAC). Multivariate logistic regression was used to examine the association between each psychological measure and subclinical atherosclerosis, after adjustment for socio-demographic factors, sleep quality, young adulthood/early middle age and late life CVD risk status, and psychological ill-being as appropriate. Results The burden of major cardiovascular disease risk factors did not significantly differ across tertiles of psychological factors. In multivariate adjusted models, trait anxiety was associated with calcification: those in the second tertile were significantly more likely to have CAC>0 compared to those in the lowest anxiety tertile [OR=1.68; 95%CI=1.09-2.58], but no significant difference was observed for Tertile III of trait anxiety [OR=1.31; 95%CI=0.75-2.27]. No association was seen between psychological measures and ABI. Conclusion Of several psychological factors, only trait anxiety was significantly associated with CAC.

show abstract

“…A study on CHD patients at baseline showed that men and women with sustained anxiety experienced a greater increase in common carotid intima-media thickness over 4 years; additionally, men showed a higher risk of 4-year plaque occurrence (47). Other studies have shown that anxiety disorders are associated with coronary artery calcification, subclinical atherosclerosis, and greater arterial stiffness, all of which are known to be associated with the development and deterioration of atherosclerosis and the associated conditions (48)(49)(50).…”

Section: The Postulated Mechanismsmentioning

confidence: 99%

A Narrative Review of the Relationship Between Coronary Heart Disease and Anxiety

Dahale

Menon

Jaisoorya

2017

Iran J Psychiatry Behav Sci

View full text Add to dashboard Cite

Context: Coronary heart disease (CHD) is the most common cause of death and disability in the world. While the relationship between depression and CHD is well documented, anxiety remains understudied, despite its common cooccurrence. Evidence Acquisition: A PubMed (MEDLINE) search was conducted in order to find articles published between January 2000 and December 2015, using the following keywords: "coronary heart disease" and "anxiety". In total, 79 out of 1138 articles were considered relevant by consensus between the authors and were reviewed. Results: According to previous studies, anxiety is suggested to increase the risk of CHD. Anxiety is associated with an increase in cardiac complications, morbidity and mortality. Also, a lower quality of life has been described among patients after acute coronary syndrome, with a few studies reporting contradictory findings. Although studies on anxiety management in CHD are sparse, selective serotonin reuptake inhibitors have been shown to be relatively safe for patients. On the other hand, psychological interventions have not been adequately evaluated, although some studies have revealed their advantages. Conclusions: Evidence suggests that anxiety is associated with the development and course of CHD. Awareness and appropriate training in cardiology settings need to be prioritized to improve early identification and initiation of effective management.

show abstract

Depressive and anxiety disorders and risk of subclinical atherosclerosis

Cited by 42 publications

References 47 publications

Antidepressant Use and Subclinical Measures of Atherosclerosis

Antidepressant Use and Subclinical Measures of Atherosclerosis

Association of depressive symptoms, trait anxiety, and perceived stress with subclinical atherosclerosis: Results from the Chicago Healthy Aging Study (CHAS)

A Narrative Review of the Relationship Between Coronary Heart Disease and Anxiety

Contact Info

Product

Resources

About