Depressive disorder in the last phase of life in patients with cardiovascular disease, cancer, and COPD: data from a 20-year follow-up period in general practice

Warmenhoven, Franca; Bor, Hans; Vissers, Kris; Weel, Chris van; Prins, Judith B.; Schers, Henk

doi:10.3399/bjgp13x667150

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…There is now widespread clinical evidence that there is an increased prevalence of anxiety and depression in individuals across a range of chronic conditions including COPD (26), heart failure (28), pulmonary hypertension (10,22), myasthenia gravis (21) and late stage cancer (5,8,36). The presence of these psychological comorbidities is associated with poorer health outcomes (35,38). Whether these associations are causative and if so in which direction is not established, although there is suggestive evidence that onset of anxiety and depression results in a worsening of dyspnea (15).…”

Section: Discussionmentioning

confidence: 99%

Effect of experimental modulation of mood on perception of exertional dyspnea in healthy subjects

Sharma

Morris

Adams

2016

Journal of Applied Physiology

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In many diseases across a range of pathologies (e.g., cardiopulmonary, neuromuscular, and cancer), chronic dyspnea, particularly on exertion, is a major debilitating symptom often associated with clinical anxiety/depression. This study aims to explore the interaction between mood state and exertional dyspnea in a healthy population. Following familiarization, 20 healthy subjects (27-54 years old) performed six 5-min treadmill tests on three separate days. On each day subjects viewed randomly assigned images designed to induce positive, negative, or neutral mood states (International Affective Picture System). For each condition, at minute intervals, subjects rated dyspnea (sensory and affective domains) in the first test and mood (valence and arousal domains) in the second test. Oxygen uptake (V̇O2 , liters/min), carbon dioxide production (V̇CO2, liters/min), ventilation (V̇E, liters/min), respiratory frequency (f(R), beats/min), and heart rate (HR, bpm), were measured throughout the exercise. V̇O2, V̇CO2, V̇E, HR, and f(R) were not statistically significantly different among the three mood states (P > 0.05). Mood valence was significantly higher with parallel viewing of positive (last 2-min mean ± SE = 6.9 ± 0.2) compared with negative pictures (2.4 ± 0.2; P < 0.001). Both sensory and affective domains of dyspnea were significantly higher during negative (sensory: 5.6 ± 0.3; affective: 3.3 ± 0.5) compared with positive mood (sensory: 4.4 ± 0.4, P < 0.001; affective: 2.1 ± 0.4, P = 0.002). These findings suggest that positive mood alleviates both the sensory and affective domains of exertional dyspnea in healthy subjects. Thus the treatment of anxiety/depression in dyspenic populations could be a worthwhile therapeutic strategy in increasing symptom-limited exercise tolerance, thereby contributing to improved quality of life.

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Section: Discussionmentioning

confidence: 99%

Effect of experimental modulation of mood on perception of exertional dyspnea in healthy subjects

Sharma

Morris

Adams

2016

Journal of Applied Physiology

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“…There is disagreement among nosologists as to whether the category is too large, confusing normal experiences with illness and encompassing mutually exclusive subsets of depressive disorders; 4 or else too small, ignoring substantial symptomatic overlap with anxiety, pain syndromes, and medically unexplained symptoms. 5 In this issue, Warmenhoven and colleagues 6 suggest that the likelihood of making a diagnosis of depressive disorder in primary care is influenced by the patient's context including their age, the presence of chronic physical conditions, and perceived need for support.…”

Section: Validity and Utilitymentioning

confidence: 99%

Depression as a culture-bound syndrome: implications for primary care

Dowrick

2013

Br J Gen Pract

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“…Anxiety and depression are common in advanced COPD, resulting from the dyspnea, disability, and isolation caused by the disease. [ 20 21 ] In a cross-sectional study of 109 patients with very severe COPD (median forced expiratory volume in 1 s [FEV 1 ] 34% predicted and most on long-term oxygen therapy [LTOT] for more than 1 year), 57% demonstrated significant depressive symptoms. [ 22 ] Studies have documented that generalized anxiety disorder and panic disorder are more prevalent in patients with COPD than in the general population.…”

Section: S Ymptom B Urden Of a mentioning

confidence: 99%