Depressive disorders among patients with gastric cancer in Taiwan: a nationwide population-based study

Hu, Li-Yu; Liu, Chia-Jen; Yeh, Chiu-Mei; Lu, Tung‐Wu; Hu, Yu-Wen; Chen, Tzeng Ji; Chen, Pan-Ming; Lee, Shyh-Chyang; Chang, Cheng-Ho

doi:10.1186/s12888-018-1859-8

Cited by 23 publications

(14 citation statements)

References 33 publications

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“…Indeed, subgroup analysis of cancer patients suggested that those who received inpatient chemotherapy within 2 months of diagnosis, reflecting more serious cancer at diagnosis, had a higher risk of MDD. Previous matched cohort studies have reported increased risk of depression in patients with uterine, 22 head and neck, 27 lung, 24 colorectal, 28,29 thyroid, 30 gastric, 31 cervical, 32 and breast cancer, 33 as well as Hodgkin lymphoma 34 . The size of our study allowed us to determine the risk of MDD for many more types of cancer than previously studied.…”

Section: Discussionmentioning

confidence: 84%

“…In addition, most patients with cancer at multiple sites had metastatic cancer, which is usually more advanced and associated with worse outcomes. Cancers with better prognoses (eg, thyroid cancer) generally had lower risks of MDD, although patients with breast cancer, which has a 5-year relative survival rate 25 and conditional 5-year relative survival rate 26 22 head and neck, 27 lung, 24 colorectal, 28,29 thyroid, 30 gastric, 31 cervical, 32 and breast cancer, 33 as well as Hodgkin lymphoma. 34 The size of our study allowed us to determine the risk of MDD for many more types of cancer than previously studied.…”

Section: Discussionmentioning

confidence: 99%

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Risk of major depressive disorder in Japanese cancer patients: A matched cohort study using employer‐based health insurance claims data

et al. 2020

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Objective: Patients with cancer are at high risk of depression. However, the risk of major depressive disorder (MDD) after cancer diagnosis has not been studied in a population setting in Japan. This cohort study used a Japanese medical claims database to examine time to MDD in cancer patients and the risk of MDD (hazard ratio; HR) compared with matched cancer-free controls. Methods: Primary endpoint was time to MDD (starting 6 months before cancer diagnosis) in adult (18-74 years) cancer patients; secondary endpoint was time to MDD (6 months before to 12 months after cancer diagnosis) in a matched cohort of cancer patients and cancer-free controls. Multivariate analyses were performed to determine HRs for all cancers and for each cancer site. Results: Of 35 008 cancer patients (mean age, 53.3 years), 2201 (6.3%) were diagnosed with MDD within 66 months. Matched cancer patients (n = 30 372) had an elevated risk of MDD compared with cancer-free controls (n = 303 720; HR [95% confidence interval] 2.96 [2.77-3.16]). MDD risk was highest in patients with multiple cancers, pancreatic cancer, and brain cancer. Compared with middle-aged patients, risk was higher in patients <40 years old and lower in patients ≥65 years old; risk tended to be higher in women than in men. Conclusions: Compared with cancer-free individuals, Japanese patients with cancer, mostly <65 years old, had an almost threefold higher risk of developing MDD within 12 months of cancer diagnosis. Physicians should watch for MDD in cancer patients and treat when necessary.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Risk of major depressive disorder in Japanese cancer patients: A matched cohort study using employer‐based health insurance claims data

et al. 2020

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“…Intriguingly, it has been reported that depression is a risk factor for cancer prognosis [70]. Besides, previous studies also showed that prevalence of MDD in cancer patients was higher compared with the general population [71,72].…”

Section: Discussionmentioning

confidence: 99%

Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder

Zhong

Zeng

et al. 2019

Neuropsychopharmacol.

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Major depressive disorder (MDD) is the most prevalent mental disorder that affects more than 200 million people worldwide. Recent large-scale genome-wide association studies (GWAS) have identified multiple risk variants that show robust association with MDD. Nevertheless, how the identified risk variants confer risk of MDD remains largely unknown. To identify risk variants that are associated with gene expression in human brain and to identify genes whose expression change may contribute to the susceptibility of MDD, we systematically integrated the genetic associations from a large-scale MDD GWAS (N = 480,359) and brain expression quantitative trait loci (eQTL) data (N = 494) using a Bayesian statistical framework (Sherlock). Sherlock integrative analysis showed that FLOT1 was significantly associated with MDD (P = 6.02 × 10 −6), suggesting that risk variants may contribute to MDD susceptibility through affecting FLOT1 expression. We further examined the expression level of FLOT1 in MDD cases and controls and found that FLOT1 was significantly upregulated in brains and peripheral blood of MDD cases compared with controls (European sample). Interestingly, we found that FLOT1 expression was also significantly upregulated in peripheral blood of first-episode drugnaive MDD cases compared with controls (P = 1.01 × 10 −7 , Chinese sample). Our study identified FLOT1 as a novel MDD risk gene whose expression level may play a role in MDD. In addition, our findings also suggest that risk variants may confer risk of MDD through affecting expression of FLOT1. Further functional investigation of FLOT1 may provide new insights for MDD pathogenesis.

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“…According to previous studies, in addition to exercise, factors that may cause a deterioration in HRQOL and depression in patients with gastric cancer include the presence of comorbidities [ 18 , 19 , 20 ], older age [ 21 ], being female [ 16 , 19 , 20 ], having a lower income [ 22 ], having a lower education level [ 23 ], and lack of a spouse [ 23 , 24 ]. Thus, these sociodemographic characteristics were considered as covariates to examine the association between exercise and both depression and HRQOL in this study.…”

Section: Introductionmentioning

confidence: 99%

Patient-Reported Outcomes of Regular Aerobic Exercise in Gastric Cancer

Lee

2021

Cancers

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The benefits of exercise for health-related quality of life (HRQOL) and depression in patients with gastrointestinal disease remain unclear, and studies on gastric cancer are scant. This study examines the association between the maintenance of regular aerobic exercise at a recommended level and depression and HRQOL in patients with gastric cancer during or after treatment. In this cross-sectional study, a face-to-face survey was used to collect data from 126 patients with primary gastric cancer during or after treatment in a tertiary acute-care hospital in Korea. Regular exercise was defined as regularly maintained aerobic exercise of at least moderate intensity consuming ≥4 metabolic equivalents for ≥150 min/wk for at least 6 months. Depression was measured using the 9-item version of the Patient Health Questionnaire, and HRQOL was assessed using the EORTC QLQ-C30. Patients who maintained aerobic exercise at a recommended level were less likely to have depression and more likely to have improved global QOL, as well as physical, role, and emotional functioning. Patients with depression were less likely to report improved global QOL and functioning. Thus, exercise can have a synergistic effect on improvement in HRQOL via indirect positive effects on depression and direct effects on HRQOL in patients with gastric cancer. Oncology nurses should encourage patients with gastric cancer who suffer from a depressive mood to set up and implement specific plans for practicing regular exercise, which can lead to an improvement in both depression and HRQOL.

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Depressive disorders among patients with gastric cancer in Taiwan: a nationwide population-based study

Cited by 23 publications

References 33 publications

Risk of major depressive disorder in Japanese cancer patients: A matched cohort study using employer‐based health insurance claims data

Risk of major depressive disorder in Japanese cancer patients: A matched cohort study using employer‐based health insurance claims data

Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder

Patient-Reported Outcomes of Regular Aerobic Exercise in Gastric Cancer

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