Depressive effect of a<i>Taenia solium</i>cysticercus factor on cultured human lymphocytes stimulated with phytohaemagglutinin

Molinari, José Luis; Tato, Patricia; Reynoso, O. A.; Cazares, J.M Leon

doi:10.1080/00034983.1990.11812458

Cited by 38 publications

(30 citation statements)

References 7 publications

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“…A factor secreted by T solium cysticercus was isolated; this factor depressed 3H-thymidine uptake by T lymphocytes in vitro (7). These results are in agreement with the immunosuppression induced in mice and pigs (8)(9)(10) Niclosamide is a drug used to treat tapeworm intestinal infections.…”

Section: Introductionsupporting

confidence: 64%

Environmental toxicants in developing countries.

Ostrosky‐Wegman

Gonsebatt

1996

Environ Health Perspect

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Health effects from environmental toxicants may be a more serious problem in developing countries compared with developed countries because the problem is potentiated by other factors: a) the lack of or failure to enforce regulations, which allows human exposures to genotoxic agents; b) undernourishment of the lower economic and social classes that comprise the most exposed populations from industrial and agricultural activities; and c) parasitic infections that afflict a wide range of populations in both urban and rural areas. Data on the genotoxic effects of different types of exposures, including environmental exposures (natural and industrial), occupational exposures, and infections and medical treatments, are presented and discussed with the point of view that all these factors must be taken into account with respect to regulation and the protection of human health. Occupational exposures in developing countries are higher than in developed countries due to lack of stringent regulations, lack of knowledge of the risks involved, and the negligence of workers. General pollution is another important issue since developed countries have established strict regulations and risky industrial processes are being exported to developing countries, along with banned substances and dangerous industrial wastes. It should be emphasized that stringent regulations in developed countries will not prevent exposures in the long term because toxic substances that are released into the environment will ultimately reach all our future generations. -Environ Health Perspect 1 04(Suppl 3): 599-602 (1996)

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Section: Introductionsupporting

confidence: 64%

Environmental toxicants in developing countries.

Ostrosky‐Wegman

Gonsebatt

1996

Environ Health Perspect

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“…Further work must be done in order to determine these cells are regulatory T cells. On the other hand, a T. solium MF was found to inhibit lymphocyte proliferation as measured by ( 3 H) thymidine uptake both in vitro and ex vivo, and IFN-c, IL-2 and IL-4 production ex vivo (Molinari et al 1990;Tato et al 1995;Arechavaleta et al 1998). Moreover, MF inhibits the inflammatory reactions around implanted metacestodes (Tato et al 1996;Molinari et al 1998).…”

Section: Discussionmentioning

confidence: 99%

“…In this sense, it was found that a T. solium metacestode factor (MF) inhibited lymphocyte proliferation (Molinari et al 1990;Tato et al 1995) as well as IL-2, IFN-c, IL-4 and TNF-a production in vitro (Arechavaleta et al 1998). When MF was fractionated on columns of Bio-gel P-6, two fractions with opposite biological activities were obtained, a suppressive fraction named F1 and a stimulating fraction named F2 (Tato et al 1995).…”

Section: Introductionmentioning

confidence: 97%

The implantation of Taenia solium metacestodes in mice induces down-modulation of T-cell proliferation and cytokine production

et al. 2005

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The purpose of this study was to determine the effect of the implantation of Taenia solium metacestodes and the treatment with suppressive metacestode factor (F1) on the ability of spleen cells from Balb/c mice to produce cytokines. Cytokine production was estimated 12 days following the implantation or 4 days after the last dose of F1 (five doses) by RT-PCR and flow cytometry analyses. Spleen cells were obtained from metacestode-implanted, F1-treated and control mice. They were stimulated with concanavalin A (ConA) ex vivo and used for RT-PCR studies and for CD25 expression and intracellular cytokine production estimations using specific monoclonal antibodies labeled with phycoerithrin or fluorescein. Results of the RT-PCR showed that all cells expressed IFN-gamma, IL-2 and IL-4 mRNAs. IL-10 mRNA was not expressed in any case. Flow cytometry analyses showed that both spleen CD4+ and CD8+ cells from metacestode-implanted or treated-F1 mice expressed significantly diminished percentages of CD25 when compared with control cells (P<0.05). The estimation of intracellular cytokines showed that the production of IL-2 and IL-4 in CD8+ cells, and of IFN-gamma in CD4+ cells from mice implanted with metacestodes was significantly impaired when compared with the values from control cells (P<0.05).

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“…A putative small RNA molecule secreted by T. solium cysticerci [Molinari et al, 1990] has the capacity to transform Syrian hamster embryo cells in vitro [Herrera et al, 1994]. We have found that this molecule induces chromosome damage in human cultured lymphocytes, suggesting that this factor could induce genetic instability in infected individuals [Herrera and Ostrosky-Wegman, 2001].…”

Section: Modulation Of Proliferation-antiproliferation Pathways and Cmentioning

confidence: 90%

Role of infectious diseases in human carcinogenesis

Herrera

Benı́tez-Bribiesca

Mohar

et al. 2005

Environ and Mol Mutagen

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The burden of human infectious diseases remains a public health problem worldwide. At least 2 billion people are affected by viral infections, and a similar number by bacteria or helminths. The long-term effects of these maladies have raised particular concern since some infectious agents have been associated with chronic human diseases, especially cancer. It is estimated that 13-20% of the world cancer cases are associated with some virus, bacteria, or helminth, e.g., human papillomavirus, Helicobacter pylori, and Schistosoma haematobium that cause cervical, stomach, and urinary bladder cancer, respectively. Certain associations between infection and malignancy are strong and irrefutable; others are still speculative. This article reviews the infectious agents that have been associated with cancer and current knowledge about the mechanisms underlying these associations.

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Depressive effect of aTaenia soliumcysticercus factor on cultured human lymphocytes stimulated with phytohaemagglutinin

Cited by 38 publications

References 7 publications

Environmental toxicants in developing countries.

Environmental toxicants in developing countries.

The implantation of Taenia solium metacestodes in mice induces down-modulation of T-cell proliferation and cytokine production

Role of infectious diseases in human carcinogenesis

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