Depressive-like behaviors in mice with Imiquimod-induced psoriasis

Guo, Jianning; Liu, Yu; Guo, Xiaoyao; Meng, Yukun; Qian, Cong; Zhao, Jingxia; Di, Tingting; Zhang, Lu; Guo, Xinwei; Wang, Yazhuo; Wang, Yan; Li, Ping

doi:10.1016/j.intimp.2020.107057

Cited by 12 publications

(8 citation statements)

References 38 publications

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“…Contrary to other studies, 9,21 we did not detect any depressivelike behaviours in the TST or FST in our mouse model. This is likely due to differences in mouse strains, and the C57-BL6 mice in our study did not show depressive-like behaviours when treated with IMQ, while BALB/c mice showed depressive-like behaviours in a sugar water preference experiment, 21 the TST, and the FST 22 and K5.Stat3C mice showed depressive-like behaviours in the FST.…”

Section: Discussioncontrasting

confidence: 99%

“…The underlying mechanisms behind the bidirectionality of this relationship between mental diseases and psoriasis are complicated and likely involve biological, psychological and neural circuit modulations. Contrary to other studies, 9,21 we did not detect any depressive‐like behaviours in the TST or FST in our mouse model. This is likely due to differences in mouse strains, and the C57‐BL6 mice in our study did not show depressive‐like behaviours when treated with IMQ, while BALB/c mice showed depressive‐like behaviours in a sugar water preference experiment, 21 the TST, and the FST 22 and K5.Stat3C mice showed depressive‐like behaviours in the FST 9 .…”

Section: Discussioncontrasting

confidence: 99%

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Resting‐state fMRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis‐like skin lesions

Chen,

Zhu,

et al. 2023

Experimental Dermatology

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Psoriasis is an autoimmune skin disease that often co‐occurs with psychological morbidities such as anxiety and depression, and psychosocial issues also lead psoriasis patients to avoid other people. However, the precise mechanism underlying the comorbidity of psoriasis and anxiety is unknown. Also, whether the social avoidance phenomenon seen in human patients also exists in psoriasis‐like animal models remains unknown. In the present study, anxiety‐like behaviours and social avoidance‐like behaviours were observed in an imiquimod‐induced psoriasis‐like C57‐BL6 mouse model along with typical psoriasis‐like dermatitis and itch‐like behaviours. The 11.7T resting‐state functional magnetic resonance imaging showed differences in brain regions between the model and control group, and voxel‐based morphometry showed that the grey matter volume changed in the basal forebrain region, anterior commissure intrabulbar and striatum in the psoriasis‐like mice. Seed‐based resting state functional connectivity analysis revealed connectivity changes in the amygdala, periaqueductal gray, raphe nuclei and lateral septum. We conclude that the imiquimod‐induced psoriasis‐like C57‐BL6 mouse model is well suited for mechanistic studies and for performing preclinical therapeutic trials for treating anxiety and pathological social avoidance in psoriasis patients.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Resting‐state fMRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis‐like skin lesions

Chen,

Zhu,

et al. 2023

Experimental Dermatology

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“…In this study, after IMQ application, the mice showed significant decreases in the time spent in the center/open arms and the frequency of entering the center/open arms in the OFT and EPM, decreased sucrose preference in the SPT and increased immobility in the TST with psoriasis-like skin lesions on their backs. These indicated that the female mice with psoriasis-like skin lesions showed significant anxiety-like and depressive-like behaviors, which was consistent with a recent study’s findings [ 4 ].…”

Section: Discussionsupporting

confidence: 93%

“…IMQ is a classical TLR receptor agonist, which can activate immune cells through the TLR pathway, thus triggering a systemic immune response [ 3 ]. Recently, the IMQ-induced psoriasis model was found to cause depressive-like and anxiety-like behaviors in male mice [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Brief Maternal Separation Promotes Resilience to Anxiety-like and Depressive-like Behaviors in Female C57BL/6J Offspring with Imiquimod-Induced Psoriasis

Zhou

et al. 2022

Brain Sciences

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Background: Psoriasis is a common chronic inflammatory skin disease that often causes depression. Early life experience affects brain development and relates to depression. Whether the effect of different MS protocols in early life on anxiety-like and depressive-like behaviors in female offspring with imiquimod (IMQ)-induced psoriasis is unknown. Methods: C57BL/6J mice were subjected to no separation (NMS), brief MS (15 min/day, MS15) or long MS (180 min/day, MS180) from postpartum days (PPD) 1 to PPD21. Then, 5% imiquimod cream was applied for 8 days in adults. Behavioral tests, skin lesions and hippocampal protein expression were also assessed. Results: We found significant psoriasis-like skin lesions in female mice following IMQ application, and mice showed anxiety-like and depressive-like behaviors. Further, increased microglial activation and decreased expression of neuroplasticity were detected in mice following IMQ application. However, after MS15 in early life, mice showed decreased anxiety-like and depressive-like behaviors, indicating resilience. Further, inhibited hippocampal neuroinflammation and increased neuroplasticity were detected. Conclusions: Collectively, this study confirms that brief MS confers resilience to the behavior deficits in female offspring with IMQ-induced psoriasis and reverses the activation of neuroinflammation and the damage of neuroplasticity injury.

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“…These findings suggest that the coptisine treatment had beneficial effects on anxiety-like behavior caused by psoriasis symptoms. A previous study reported that mice with IMQ-induced psoriasis showed depression-like behavior in the sucrose preference test (SPT) [60]. This study indicated that the immobility time of IMQ-treated mice in TST was higher than the normal mice, but the difference was not significant, demonstrating that the depression behavior was unclear in psoriasis mice.…”

Section: Discussionmentioning

confidence: 75%

Coptisine Alleviates Imiquimod-Induced Psoriasis-like Skin Lesions and Anxiety-like Behavior in Mice

et al. 2022

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Psoriasis is a common inflammatory skin disorder, which can be associated with psychological disorders, such as anxiety and depression. This study investigated the efficacy and the mechanism of action of a natural compound coptisine using imiquimod (IMQ)-induced psoriasis mice. Coptisine reduced the severity of psoriasis-like skin lesions, decreased epidermal hyperplasia and the levels of inflammatory cytokines TNF-α, IL-17, and IL-22. Furthermore, coptisine improved IMQ-induced anxiety in mice by increasing the number of entries and time in open arms in the elevated plus maze (EPM) test. Coptisine also lowered the levels of inflammatory cytokines TNF-α and IL-1β in the prefrontal cortex of psoriasis mice. HaCaT keratinocytes and BV2 microglial cells were used to investigate the effects of coptisine in vitro. In M5-treated HaCaT cells, coptisine decreased the production of IL-6, MIP-3α/CCL20, IP-10/CXCL10, and ICAM-1 and suppressed the NF-κB signaling pathway. In LPS-stimulated BV2 cells, coptisine reduced the secretion of TNF-α and IL-1β. These findings suggest that coptisine might be a potential candidate for psoriasis treatment by improving both disease severity and psychological comorbidities.

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Depressive-like behaviors in mice with Imiquimod-induced psoriasis

Cited by 12 publications

References 38 publications

Resting‐state fMRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis‐like skin lesions

Resting‐state fMRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis‐like skin lesions

Brief Maternal Separation Promotes Resilience to Anxiety-like and Depressive-like Behaviors in Female C57BL/6J Offspring with Imiquimod-Induced Psoriasis

Coptisine Alleviates Imiquimod-Induced Psoriasis-like Skin Lesions and Anxiety-like Behavior in Mice

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