Depressive mood and quality of life in functional gastrointestinal disorders: differences between functional dyspepsia, irritable bowel syndrome and overlap syndrome

Lee, Heon Jeong; Lee, Sun Young; Kim, Jeong Hwan; Sung, In Kyung; Park, Hyung Seok; Jin, Choon Jo; Na, Kyoung-Sae; Yoon, Hiejin; Chun, Hoon Jai

doi:10.1016/j.genhosppsych.2010.05.002

Cited by 57 publications

(60 citation statements)

References 20 publications

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“…Lee et al have reported a significant correlation between clinical depression and FD [37]. We have also reported that SRQ-D scores in FD patients are relatively higher than that in healthy volunteers.…”

Section: Discussionsupporting

confidence: 69%

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Distinct Associations Between Depression Status and Initial Phase of Gastric Emptying in Functional Dyspepsia and Healthy Volunteers

Futagami¹

2014

Int J Gastroenterol Disord Ther

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Background/Aims: The association between initial phase of gastric emptying and clinical symptoms and depression status in functional dyspepsia has not been studied in detail. Methods: The subjects were 20 patients with Rome III-based functional dyspepsia and healthy volunteers. We evaluated upper abdominal symptoms using GDSS score and used Self-Rating Questionnaire for Depression (SRQ-D) scores to determine depression status. Gastric motility was evaluated with the 13 C-acetate breath test. Results: AUC 15 value as initial gastric emptying within 15 mins in FD patients was significantly higher compared to that in healthy volunteers. T max value as a marker of delayed gastric emptying in FD patients was also significantly higher compared to that in healthy volunteers. There were not significant relationships between clinical symptoms and AUC 5 and AUC 15 values in FD patients and healthy volunteers. In contrast, there were significant correlations (p=0.047, p=0.049) between SRQ-D score and AUC 5 and AUC 15 values in healthy volunteers, albeit there were not significant correlations in FD patients. Conclusions: Impairment of AUC 15 or AUC 15 /AUC inf as well as delayed gastric emptying would play important roles in functional dyspepsia. Further studies are necessary to clarify whether various clinical symptoms and depression status are related to initial gastric emptying at postprandial 15 mins phase.

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Section: Discussionsupporting

confidence: 69%

“…Studies have shown that the prevalence of psychological disorders is significantly higher in patients with FD than in the general population [37,38]. Lee et al have reported a significant correlation between clinical depression and FD [37].…”

Section: Discussionmentioning

confidence: 99%

Distinct Associations Between Depression Status and Initial Phase of Gastric Emptying in Functional Dyspepsia and Healthy Volunteers

Futagami¹

2014

Int J Gastroenterol Disord Ther

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“…7 Similarly, the presence of depression has been reported to be a significant associated factor in the overlap of FD and IBS. 34 Therefore, a wide variety of variables may act as risk factors for the overlap of several FGIDs, depending on the variables to be considered. In this study, the co-incidence of HNP or pulmonary diseases, reduced fiber intake, and laxatives use independently affected the overlap of constipation with disorders discussed in this study.…”

Section: Discussionmentioning

confidence: 99%

Nationwide Multicenter Study for Overlaps of Common Functional Gastrointestinal Disorders in Korean Patients With Constipation

Park

Jee

Lee

et al. 2017

J Neurogastroenterol Motil

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Background/AimsIn spite of increased concerns about the overlaps among the various functional gastrointestinal disorders (FGIDs), studies for the overlap between constipation and other common FGIDs are rare. Therefore, we investigated the patterns of overlaps between constipation and other common FGIDs. Methods This study was designed as a prospective nationwide multi-center questionnaire study using Rome III questionnaires for functional dyspepsia (FD), irritable bowel syndrome (IBS), and functional constipation (FC), as well as various questionnaires about patients' information, degree of symptoms, and quality of life. For the evaluation of gastroesophageal reflux disease (GERD), GERD-Q was used. Results From 19 centers, 759 patients with constipation were enrolled. The proportions of FC and IBS subtypes of constipation (IBS-C) were 59.4% and 40.6%, respectively. Among them, 492 (64.8%) showed no overlap. One hundred and thirty-six patients (17.9%) presented overlapping GERD, and 80 patients (10.5%) presented overlapping FD. Fifty one (6.7%) of patients were overlapped by both GERD and FD. Coincidental herniated nucleus pulposus (HNP) (P = 0.026) or pulmonary diseases (P = 0.034), reduced fiber intake (P = 0.013), and laxative use (P < 0.001) independently affected the rate of overlaps. These overlapping conditions negatively affected the constipation-associated quality of life, general quality of life, and degree of constipation. ConclusionsThe overlap of GERD or FD was common in patients with constipation. Coincidental HNP or pulmonary diseases, reduced fiber intake, and laxatives use were found to be independent associated factors for overlapping common FGIDs in Korean patients with constipation.

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“…10,52 Subjects with overlapping FD (Rome III) and IBS showed a significant increase in the severity of psychopathologic features, including global sensitivity index, obsessive compulsiveness, interpersonal sensitivity, depression, anxiety, anger and hostility, phobic anxiety, paranoid ideation, and psychoticism. 53 Similarly, Lee et al 54 showed that depression was significantly associated with the overlap of FD (Rome III) and IBS. One population-based study by Minocha et al 55 demonstrated that overlap of IBS and dyspepsia (Rome II) was more common in Caucasians than in African Americans, and showed that Caucasians with overlap were likely to be married, live in an urban area, and have low education.…”

Section: Dyspepsia With Lower Gastrointestinal Diseasesmentioning

confidence: 94%

Overlap in Patients With Dyspepsia/Functional Dyspepsia

Fujiwara¹

2014

J Neurogastroenterol Motil

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Patients with dyspepsia/functional dyspepsia (FD) show frequent overlapping of other gastrointestinal (GI) diseases, such as irritable bowel syndrome, and non-GI diseases, in addition to internal subgroup overlapping. These overlap patients have more frequent or more severe symptoms, poorer health-related quality of life and higher somatization scores, and they are more likely to experience anxiety, depression or insomnia compared to non-overlap patients. The higher prevalence of overlap in patients with dyspepsia/FD is not by chance, indicating common pathogeneses, including visceral hypersensitivity, altered GI motility, infection, and stressful early life events. There are few clinical trials targeting overlap in patients with dyspepsia/FD, and no therapeutic strategy has been established. Further studies in this research area are needed. In this review, we describe the epidemiology, pathogenesis and treatment of overlap in patients with dyspepsia/FD.

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Depressive mood and quality of life in functional gastrointestinal disorders: differences between functional dyspepsia, irritable bowel syndrome and overlap syndrome

Cited by 57 publications

References 20 publications

Distinct Associations Between Depression Status and Initial Phase of Gastric Emptying in Functional Dyspepsia and Healthy Volunteers

Distinct Associations Between Depression Status and Initial Phase of Gastric Emptying in Functional Dyspepsia and Healthy Volunteers

Nationwide Multicenter Study for Overlaps of Common Functional Gastrointestinal Disorders in Korean Patients With Constipation

Overlap in Patients With Dyspepsia/Functional Dyspepsia

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