Depressive state relates to female oxidative DNA damage via neutrophil activation

Irie, Masahiro; Asami, Shinya; Ikeda, Masato; Kasai, Hiroshi

doi:10.1016/j.bbrc.2003.10.105

Cited by 112 publications

(74 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Glucocorticoids, the primary adrenal hormones secreted during stress, increase oxidative stress damage to neurons, in part by increasing glutamate and calcium and decreasing antioxidant enzymes (23,24). It is also notable that, in women, self-reported distress has been related to greater oxidative DNA damage (8-OH-dG) (12). Oxidative stress shortens telomeres in cells cultured in vitro (10).…”

Section: Discussionmentioning

confidence: 99%

“…Most notably, in vitro, oxidative stress can shorten telomeres and antioxidants can decelerate shortening (9,10). Perceived stress has been linked to one measure of oxidative DNA damage in leukocytes in women (11,12). Given these observed links, we hypothesized that chronic psychological stress may lead to telomere shortening and lowered telomerase function in peripheral blood mononuclear cells (PBMCs) and to oxidative stress.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Accelerated telomere shortening in response to life stress

Epel

Blackburn

Lin

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

2,590

1,986

View full text Add to dashboard Cite

Numerous studies demonstrate links between chronic stress and indices of poor health, including risk factors for cardiovascular disease and poorer immune function. Nevertheless, the exact mechanisms of how stress gets ''under the skin'' remain elusive. We investigated the hypothesis that stress impacts health by modulating the rate of cellular aging. Here we provide evidence that psychological stress-both perceived stress and chronicity of stress-is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, which are known determinants of cell senescence and longevity, in peripheral blood mononuclear cells from healthy premenopausal women. Women with the highest levels of perceived stress have telomeres shorter on average by the equivalent of at least one decade of additional aging compared to low stress women. These findings have implications for understanding how, at the cellular level, stress may promote earlier onset of age-related diseases.psychological stress ͉ telomere length ͉ telomerase ͉ oxidative stress

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Accelerated telomere shortening in response to life stress

Epel

Blackburn

Lin

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

2,590

1,986

View full text Add to dashboard Cite

show abstract

“…A high GHQ score, which indicates poor psychological well-being, is associated with suicide attempts and psychiatric disorders such as alcoholism, major depressive episodes (20) as well as high mortality after stroke or cerebrovascular diseases (21,22). Irie et al, who examined the relationship of 8-OH-dG level, a biomarker of cancer-related oxidative DNA damage, to GHQ-12 score in female workers have found a higher 8-OH-dG level in female workers with a high GHQ-12 score, suggesting that poor psychological well-being is related to a higher risk of developing cancer due to oxidative DNA damage in females, possibly via neutrophil activation (23). Therefore, the relationships of poor psychological well-being with the subsequent development of mental and physical diseases and mortality are likely to reinforce the importance of the assessment of psychological factors, work systems and lifestyles, followed by appropriate intervention to alleviate these psychological symptoms (24).…”

Section: Discussionmentioning

confidence: 99%

Psychological factors including sense of coherence and some lifestyles are related to general health questionnaire-12 (GHQ-12) in elderly workers in Japan

Matsuzaki

Sagara

Ohshita

et al. 2007

Environ Health Prev Med

View full text Add to dashboard Cite

Objectives: The number of elderly workers has also been increasing and poor psychological wellbeing in elderly workers has been reported. The aim of this study is to elucidate the factors that are related to poor psychological well-being in elderly workers.Methods: We administered General Health Questionnaire-12 (GHQ-12) as an indicator of psychological well-being to 330 male elderly workers in the age range of 50-69, and analyzed different psychological factors, namely sense of coherence (SOC), and physical and lifestyle variables such as blood pressure, serum total cholesterol, smoking frequency, alcohol intake, exercise frequency, and body mass index (BMI) that are related to GHQ-12.Results: When the cut-off point of GHQ-12 was 2/3, 97 workers who showed high GHQ-12 score were classified as one group having poor psychological well-being. A statistically significantly lower SOC score, higher stress score, lower frequency of exercise, higher smoking score and higher BMI, but not longer working hours or higher shift work score in the workers with higher GHQ-12 scores were observed than in the workers with normal GHQ-12 scores. Multiple logistic regression analysis showed that the low SOC score, low frequency of exercise, high smoking frequency and high BMI significantly contributed to the high GHQ-12 score.Conclusions: A low SOC score in elderly workers is assumed to be directly related to poor psychological well-being, or via the development of lifestyle problems such as lack of exercise, obesity, and smoking in elderly workers. This assumption must be confirmed by conducting future intervention studies on lifestyle.

show abstract

“…Shortening of telomeres with stress and depression could be explainable by referencing two other bodies of research: the first relating stress and depression to changes in certain biological mediators, and the second relating changes in the same biological mediators to telomere shortening. For example, chronically stressed and depressed individuals (especially females) have increased levels of circulating oxidative stress markers (e.g., increased F2-isoprostanes, 8-hydroxy-deoxyguanosine (8-OHdG)), along with decreases in anti-oxidant enzymes, and the concentration of oxidative stress markers is directly correlated with the severity of depression (Forlenza and Miller 2006;Irie et al 2002Irie et al , 2003Tsuboi et al 2004). Additionally, depression may be associated with increased levels of pro-inflammatory cytokines (Leonard 2000;O'Brien et al 2004), although not all studies support this.…”

Section: Editorialmentioning

confidence: 99%