Depressive symptoms after treatment in hepatocellular carcinoma survivors: prevalence, determinants, and impact on health‐related quality of life

Mikoshiba, Naoko; Miyashita, Mitsunori; Sakai, Tomoko; Tateishi, Ryosuke; Koike, Kazuhiko

doi:10.1002/pon.3300

Cited by 21 publications

(37 citation statements)

References 44 publications

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“…A poorer global QoL at baseline was also found to be a moderator of the effect of the NUCAI in both the full-case and intention-to-treat analyses, with patients with a worse global QoL at baseline responding better (a decrease of 6.7 points on the depressive symptoms scale) to treatment than patients with a better global QoL. While we did not find any articles in the literature that expressly investigated this, several studies have shown that higher depressive symptom scores or depression are related to a lower global QoL in cancer patients [ 19 , 25 , 26 ]. Overall, no significant improvements were found for patients who had high (+1 SD) global QoL, emotional functioning, and social functioning scores.…”

Section: Discussionmentioning

confidence: 74%

“…It should be mentioned that, with the NUCAI, patients are encouraged to bring their partners to intervention sessions. Mikoshiba et al [ 19 ] found that living alone was associated with an increased likelihood of depressive symptoms in patients with liver cancer. Perhaps if a partner follows the intervention with the patient, he/she can discuss the intervention with the patient at home and might stimulate and support the patient.…”

Section: Discussionmentioning

confidence: 99%

“…Less is known about which variables moderate depressive symptoms in patients with head and neck cancer. In a literature search, we found younger age [ 14 , 15 ], female gender [ 16 ], lower educational level [ 17 , 18 ], living alone and unemployment [ 19 ], higher tumor stage [ 14 , 20 ], adjuvant chemotherapy [ 16 ], smoking and daily drinking [ 17 ], avoidance and helpless coping [ 4 , 21 , 22 ], lower social support [ 23 , 24 ], lower global QoL [ 15 , 19 , 25 , 26 ], lower physical functioning [ 27 ], lower emotional functioning [ 28 ], lower social functioning [ 27 ], higher level of pain [ 29 , 30 ], more intrusive thoughts [ 31 ], lower self-esteem [ 32 ], and lower self-efficacy [ 32 , 33 ] to influence depressive symptoms in patients with cancer. The purpose of the current study was to investigate whether these variables, which are associated with depressive symptoms in cancer patients, moderate the response to a nurse-led psychosocial intervention [ 11 ] for the treatment of depressive symptoms in head and neck cancer patients.…”

Section: Introductionmentioning

confidence: 99%

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Moderators of the response to a nurse-led psychosocial intervention to reduce depressive symptoms in head and neck cancer patients

Meulen

May

Leeuw

et al. 2015

Support Care Cancer

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PurposeLittle is known about the variables that moderate the response to psychosocial interventions to decrease depressive symptoms in cancer patients. The purpose of this study was to determine whether variables associated with depressive symptoms in cancer patients in general moderate the response to a nurse-led psychosocial intervention in patients with head and neck cancer.MethodsThis study is a secondary analysis of a randomized controlled trial evaluating the effect of the nurse counseling and after intervention (NUCAI) on depressive symptoms 12 months after cancer treatment in patients with head and neck cancer. Of 205 patients, 103 received the NUCAI and 102 care as usual. Twenty-one variables were selected for analysis and a linear regression analyses including interaction terms was performed for each variable separately. Significant moderators were post hoc probed.ResultsFour moderators were found: marital status, global quality of life, emotional functioning, and social functioning. Patients who were married/living together or had low scores for global quality of life, and emotional or social functioning at baseline benefited more from the NUCAI than patients who were single or with high scores for global quality of life and emotional or social functioning.ConclusionsMarital status, global quality of life, and emotional and social functioning of head and neck cancer patients should be evaluated to determine whether they might benefit from a psychosocial intervention to combat depressive symptoms. Further research is necessary to replicate results and to contribute to the knowledge needed to make screening and personalized patient care possible.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Moderators of the response to a nurse-led psychosocial intervention to reduce depressive symptoms in head and neck cancer patients

Meulen

May

Leeuw

et al. 2015

Support Care Cancer

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“…They report lower QOL than the general population and than those with liver disease but without HCC [15, 16]. Poor QOL is driven by several symptoms including fatigue, weakness, anorexia, abdominal pain/bloating, and depression [14, 16–19]. …”

Section: Introductionmentioning

confidence: 99%

Role functioning is associated with survival in patients with hepatocellular carcinoma

et al. 2014

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Background Prior studies assessing quality of life (QOL) in patients with hepatocellular carcinoma (HCC) primarily included patients with preserved liver function and/or early HCC, leading to overestimation of QOL. Our study's aim was to evaluate the association of QOL with survival among a cohort of cirrhotic patients with HCC that was diverse with respect to liver function and tumor stage. Methods We conducted a prospective cohort study among cirrhotic patients with HCC from a large urban safety-net hospital between April 2011 and September 2013. Patients completed two self-administered surveys, the EORTC QLQ-C30, and QLQ-HCC18, prior to treatment. We used generalized linear models to identify correlates of QOL. Survival curves were generated using Kaplan–Meier analysis and compared using log rank test to determine whether QOL is associated with survival. Results A total of 130 treatment-naïve patients completed both surveys. Patients reported high cognitive and social function (median scores 67) but poor global QOL (median score 50) and poor role function (median score 50). QOL was associated with cirrhosis-related (p = 0.02) and tumor-related (p = 0.02) components of Barcelona Clinic Liver Cancer (BCLC) tumor stage. QOL was associated with survival on univariate analysis (HR 0.37, 95 % CI 0.16–0.85) but became nonsignificant (HR 0.82, 95 % CI 0.37–1.80) after adjusting for BCLC stage and treatment. Role functioning was significantly associated with survival (HR 0.40, 95 % CI 0.20–0.81), after adjusting for Caucasian race (HR 0.31, 95 % CI 0.16–0.59), BCLC stage (HR 1.51, 95 % CI 0.21– 1.89), and treatment (HR 0.57, 95 % CI 0.33–0.97). Conclusions Role function has prognostic significance and is important to assess in patients with HCC.

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“…Depression has a substantial effect on work and daily lives, sleeping, and general health [ 16 , 17 ]. Studies in HCC patients treated with TACE revealed that patients experienced variant depressive episodes during posttreatment [ 5 , 7 , 18 , 19 ] and there was a strong correlation with fatigue [ 18 ] and sleep disturbance [ 5 , 18 ], impacting quality of life [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Acupressure on Fatigue and Depression in Hepatocellular Carcinoma Patients Treated with Transcatheter Arterial Chemoembolization: A Quasi-Experimental Study

Lan

Lin

Chen

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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This study was to examine the effects of acupressure on fatigue and depression in HCC patients undergoing TACE. A quasiexperimental study design was used. Patients were evaluated at five time points: before treatment (T1) and 2, 3, 4, and 5 days after treating TACE (T2, T3, T4, and T5). Fatigue and depression were assessed by a VAS fatigue scale and a VAS depression scale at each time point. TFRS and BDI were administered at T1 and T5. Patients' fatigue and depression were significantly higher at T5 than at T1 in two groups. Fatigue and depression increased in both the experimental and control groups' patients over the five days of hospitalization during which TACE and chemotherapy were administered. The experimental group had significantly less fatigue than the control group, with lower subscale scores on physical, psychosocial, daily, and overall fatigue. There were no differences between the groups on depression. At posttest, the experimental group experienced lower physical, psychosocial, daily, and overall fatigue than the control group. Acupressure can improve fatigue in HCC patients during treatment with TACE but did not alleviate depression. Discharge planning should include home care for management of fatigue and depression.

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Depressive symptoms after treatment in hepatocellular carcinoma survivors: prevalence, determinants, and impact on health‐related quality of life

Abstract: This study suggests that after treatment, many HCC survivors experience depressive symptoms that are strongly associated with poorer HRQOL.

Cited by 21 publications

References 44 publications

Moderators of the response to a nurse-led psychosocial intervention to reduce depressive symptoms in head and neck cancer patients

Moderators of the response to a nurse-led psychosocial intervention to reduce depressive symptoms in head and neck cancer patients

Role functioning is associated with survival in patients with hepatocellular carcinoma

Effects of Acupressure on Fatigue and Depression in Hepatocellular Carcinoma Patients Treated with Transcatheter Arterial Chemoembolization: A Quasi-Experimental Study

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