The aim of the present study was to investigate the degree of depressive symptoms and life satisfaction (LS) as well as the association between acculturation and depressive symptoms among a large sample of persons with Turkish migration background in Germany, taking into account gender-and migration-related differences. Methods: This study was part of a pretest for a large national epidemiological cohort study in Germany. Acculturation was measured using the Frankfurt Acculturation Scale (FRACC). Based on the median split of the two subscales, four acculturative styles according to Berry (integration, assimilation, separation and marginalization) were determined. Depressive symptoms were assessed with the depression module (PHQ-9) from the Patient Health Questionnaire. LS was assessed with a single item on a scale from 1 = bad to 5 = excellent. Differences in levels of depressive symptoms and LS in relation to gender and generation of migration were tested with analysis of covariance, controlling for age. Gender-stratified multiple linear regression analyses were also conducted for depressive symptoms as criterion variable. Results: 328 Turkish migrants participated (61.3% women). The cutoff value of ≥10 for the PHQ-9 was achieved by 33.2% of the women and 26.4% of the men (p=0.209, j=0.071). In female migrants, the age-adjusted mean score for depressive symptoms was 7.81 (SD=6.42), in males 6.70 (SD=6.41) (p=0.137, h 2 =0.007). After controlling for unemployment status, women showed a trend for being more frequently depressed than men (p=0.055, j=0.117) and also demonstrated a trend for higher levels of depressive symptoms (p=0.072, h 2 =0.012). No significant gender-specific difference was found concerning age-adjusted mean score for LS (p=0.547, h 2 =0.001), also when controlled for unemployment status (p=0.322, h 2 =0.004). In both sexes, the second generation