Depressive symptoms and cholesterol-lowering drugs

Duits, Nils; Bos, Fionneke M.

doi:10.1016/0140-6736(93)92591-g

Cited by 42 publications

(20 citation statements)

References 4 publications

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“…These findings support early suggestions that cholesterol lowering itself affects mood 49 . A contrasting study 40 , however, proposed that statins themselves alter mood as even in their subgroup of participants with the lowest serum cholesterol (LDL-C < 100), only those taking lipid-lowering drugs demonstrated increased aggression.…”

Section: Potential Methodological Limitations Of Reviewed Studiessupporting

confidence: 89%

The effects of statins on mood: a review of the literature

While

Keen

2010

European Journal of Cardiovascular Nursing

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Section: Potential Methodological Limitations Of Reviewed Studiessupporting

confidence: 89%

The effects of statins on mood: a review of the literature

While

Keen

2010

European Journal of Cardiovascular Nursing

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“…This difference might again reflect the age of the subject or perhaps the chronicity of treatment (in general these case reports relate to treatment for greater than a month). However, one of the cases of Duits & Bos [29] developed psychotic depression after 4 days and another patient depressive illness after 1 month. The differences are not explicable in terms of the dose given as our subjects were given therapeutic doses of simvastatin and pravastatin.…”

Section: Discussionmentioning

confidence: 99%

“…The subjects of Morgan and colleagues were not being treated for hypercholesterolaemia and therefore one would assume that their low cholesterol levels were fairly static. In case reports associations between simvastatin [29] and pravastatin [30] and depression have been suggested in hypercholesterolaemic patients. No association between these agents and depression was found in our study.…”

Section: Discussionmentioning

confidence: 99%

Do cholesterol‐lowering agents affect brain activity? A comparison of simvastatin, pravastatin, and placebo in healthy volunteers.

Harrison

Ashton

1994

Brit J Clinical Pharma

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“…Neuropsychiatric ADRs of statins, including suicide and aggression, have been reported in pharmacovigilance databases [20, 25] and in adverse event reports and series [18, 19, 26]. Moreover, adverse behaviors have been reported in settings of low cholesterol [27–29]; and of lower omega-3 fatty acid levels (the omega-3 to omega-6 ratio is reportedly reduced with statins) [30–32].…”

Section: Introductionmentioning

confidence: 99%

Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series

Cham

Koslik

Golomb

2015

Drug Saf - Case Rep

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Psychiatric adverse drug reactions (ADRs) have been reported with statin use, but the literature regarding statin-associated mood/behavioral changes remains limited. We sought to elicit information germane to natural history and characteristics of central nervous system/behavioral changes in apparent connection with statin and/or cholesterol-lowering drug use, and delineate mechanisms that may bear on an association. Participants (and/or proxies) self-referred with behavioral and/or mood changes in apparent association with statins completed a survey eliciting cholesterol-lowering drug history, character and impact of behavioral/mood effect, time-course of onset and recovery in relation to drug use/modification, co-occurrence of recognized statin-associated ADRs, and factors relevant to ADR causality determination. Naranjo presumptive ADR causality criteria were assessed. Participants (n = 12) reported mood/behavior change that commenced following statin initiation and persisted or progressed with continued use. Reported problems included violent ideation, irritability, depression, and suicide. Problems resolved with drug discontinuation and recurred with rechallenge where attempted. Eight met presumptive criteria for “probable” or “definite” causality; others had additional factors not considered in Naranjo criteria that bear on casual likelihood. (1) Simvastatin 80 mg was followed in 5 days by irritability/depression culminating in suicide in a man in his 40s (Naranjo criteria: possible causality). (2) Simvastatin 10 mg was followed within 2 weeks by depression in a woman in her 50s (probable causality). (3) Atorvastatin 20 mg was followed in ~1 month by depression and irritability/aggression in a male in his 50s (probable causality). (4) Atorvastatin 10 mg was followed in several months by aggression/irritability and depression culminating in suicide in a man in his 40s (possible causality). (5) Fenofibrate + rosuvastatin (unknown dose), later combined with atorvastatin were followed in 1 month by aggression/irritability in a male in his 30s (probable causality). (6) Lovastatin (unknown dose and time-course to reaction) was followed by depression, dyscontrol of bipolar disorder, and suicide attempts in a male in his 40s (possible causality). (7) Atorvastatin 20 mg was followed within 2 weeks by cognitive compromise, and nightmares, depression, and anxiety culminating in suicide in a man in his teens (definite causality). (8) Simvastatin 10 mg was followed (time-course not recalled) by depression, aggression/irritability culminating in suicide in a man in his 60s (possible causality). (9) Simvastatin 20 mg then atorvastatin 10 mg were followed (time-course not provided) by irritability/aggression in a man in his 60s (definite causality). (10) Atorvastatin 10 then 20 then 40 mg were followed shortly after the dose increase by violent ideation and anxiety in a man in his 30s (probable causality). (11) Atorvastatin 20 mg and then simvastatin 20 mg were followed in 2 weeks by aggression/irritability in a man in his...

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Depressive symptoms and cholesterol-lowering drugs

Cited by 42 publications

References 4 publications

The effects of statins on mood: a review of the literature

The effects of statins on mood: a review of the literature

Do cholesterol‐lowering agents affect brain activity? A comparison of simvastatin, pravastatin, and placebo in healthy volunteers.

Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series

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