Depressive symptoms and multi-joint pain partially mediate the relationship between obesity and opioid use in people with knee osteoarthritis

Carlesso, Lisa C.; Jafarzadeh, S. Reza; Stokes, Andrew; Felson, David T.; Wang, Na; Law, Laura Frey; Lewis, Cora E.; Nevitt, Michael C.; Neogi, Tuhina

doi:10.1016/j.joca.2022.06.002

Cited by 2 publications

(2 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data additionally revealed that obesity and the use of pain medication were more common amongst those with depression in our population compared to those without depression. Obesity plays a considerable role beyond its structural impact on osteoarthritis [ 50 ], including conferring increased risk of depression and changing the trajectory of depression in individuals with knee OA, such as contributing to its progression to worse depressive symptoms or the development of comorbidities [ 51 ]. The reported opioid use in women with OA was 17% in those who were depressed compared to 5.2% in those without depression ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Predictors of Depression in Women with Osteoarthritis: Cross-Sectional Analysis of Nationally Representative Survey Data

Ravi,

DeMarco,

Gebauer

et al. 2024

Healthcare

View full text Add to dashboard Cite

Osteoarthritis (OA) is the most common joint disease in the US and can increase the risk of depression. Both depression and OA disproportionately affect women, yet this study is one of few on depression prevalence, treatment across age groups, and predictors in women with OA. Data were extracted from the 2011–March 2020 National Health and Nutrition Examination Survey (NHANES). Women aged ≥ 45 years with self-reported osteo- or degenerative arthritis were included. Outcomes were depression (assessed with PHQ-9) and treatment (self-reported pharmacotherapy and mental health services). Logistic regression was used to examine associations between age group, covariates, and outcomes. Overall, depression prevalence was 8%, with higher proportions among those 45–64 years old. Aging was associated with reduced odds of depression (Age 65–79: OR 0.68 (95% CI: 0.52–0.89); Age 80+: OR 0.49 (95% CI: 0.33–0.74); vs. Age 45–54). Of those with a positive depression screen, 21.6% documented some form of treatment. Age group was not statistically different between those treated and those not treated. Women aged 45–64 with osteoarthritis may be at increased risk of depression, and most are not treated. As depression is related to increased pain and risk of rehospitalization, future research should prioritize interventions to increase uptake of depression treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence and Predictors of Depression in Women with Osteoarthritis: Cross-Sectional Analysis of Nationally Representative Survey Data

Ravi,

DeMarco,

Gebauer

et al. 2024

Healthcare

View full text Add to dashboard Cite

show abstract

“…It is also argued that because stress and depression are both associated with the development of later life medical co-morbidities, as well as the possible onset and worsening of osteoarthritis pain, disability, and poor health, plus possible excess opioid usage [66], very careful evaluation to tease out the presence of physical symptoms, versus emotional distress, followed by interventions such as relaxation, is strongly indicated [67],…”

Section: Discussionmentioning

confidence: 99%

Osteoarthritis Depression Impacts and Possible Solutions Among Older Adults: Year 2021-2022 in Review

Marks

2022

JARH

View full text Add to dashboard Cite

Background Osteoarthritis, a serious joint disease, said to represent a generally declining state of wellbeing and function among many older adults has been shown to be affected to a considerable degree by various negative beliefs and inactions rather than degradation alone. Aim This review examines the case of depression as this pertains to the older adult with osteoarthritis of one or more joints. Specifically, the most up to date information on this topic was sought, as care improvements over the past decade have not shown any impactful population wide results. Method Reviewed were relevant 2021-2022 research and review articles specifically pertaining to what is being observed currently by researchers as far as osteoarthritis-depression linkages goes, as these may reveal opportunities for more profound research, and practice-based endeavors. Results In line with 60 years of prior research, it appears a clinically important role for depression in some osteoarthritis cases cannot be ruled out. It further appears that if detected and addressed early on, many older adults suffering from osteoarthritis may yet be enabled to lead a quality life, rather than a distressing and excessively impaired state of being. Those older osteoarthritis cases requiring surgery who suffer from concomitant depressive symptoms are likely to be disadvantaged in the absence of efforts to treat and identify this psychosocial disease correlate. Conclusion Providers and researchers are encouraged to pursue this line of inquiry and begin to map clinical osteoarthritis measures with those that can track cognitive patterns, musculoskeletal, features and inflammatory reactions along with valid depression indicators among carefully selected osteoarthritis sub groups.

show abstract

Depressive symptoms and multi-joint pain partially mediate the relationship between obesity and opioid use in people with knee osteoarthritis

Cited by 2 publications

References 58 publications

Prevalence and Predictors of Depression in Women with Osteoarthritis: Cross-Sectional Analysis of Nationally Representative Survey Data

Prevalence and Predictors of Depression in Women with Osteoarthritis: Cross-Sectional Analysis of Nationally Representative Survey Data

Osteoarthritis Depression Impacts and Possible Solutions Among Older Adults: Year 2021-2022 in Review

Contact Info

Product

Resources

About