Depressive symptoms and suicidal behavior after first-episode psychosis: A comprehensive systematic review

Coentre, Ricardo; Talina, Miguel; Góis, Carlos; Figueira, Maria Luísa

doi:10.1016/j.psychres.2017.04.010

Cited by 71 publications

(57 citation statements)

References 33 publications

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“…The associations between BL depression and the development of apathy is intriguing. Depression is common also in non-affective psychotic disorders, especially in FEP [62,63]. Although the phenomenology of depressive symptoms resembles those of negative symptoms [64], the different symptoms do not cluster together in factor analyses and show modest or inconsistent overlap in both cross-sectional-and longitudinal studies [65].…”

Section: Early Clinical or Demographic Predictors Of Apathy Developmementioning

confidence: 99%

Trajectory and early predictors of apathy development in first-episode psychosis and healthy controls: a 10-year follow-up study

Lyngstad

Gardsjord

Engen

et al. 2020

Eur Arch Psychiatry Clin Neurosci

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Apathy is prevalent in first-episode psychosis (FEP) and associated with reduced global functioning. Investigations of the trajectory of apathy and its early predictors are needed to develop new treatment interventions. We here measured the levels of apathy over the first 10 years of treatment in FEP and in healthy controls (HC). We recruited 198 HC and 198 FEP participants. We measured apathy with the Apathy Evaluation Scale, self-report version, psychotic symptoms with the Positive and Negative Syndrome Scale, depression with the Calgary Depression Scale for Schizophrenia, functioning with the Global Assessment of Functioning Scale, and also estimated the duration of untreated psychosis (DUP). The longitudinal development of apathy and its predictors were explored using linear mixed models analyses. Associations to functioning at 10 years were investigated using multiple hierarchical linear regression analyses. In HC, mean apathy levels were low and stable. In FEP, apathy levels decreased significantly during the first year of treatment, followed by long-term stability. High individual levels of apathy at baseline were associated with higher apathy levels during the follow-up. Long DUP and high baseline levels of depression predicted higher apathy levels at follow-ups. The effect of DUP was persistent, while the effect of baseline depression decreased over time. At 10 years, apathy was statistically significantly associated with reduced functioning. The early phase of the disorder may be critical to the development of apathy in FEP.

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Section: Early Clinical or Demographic Predictors Of Apathy Developmementioning

confidence: 99%

Trajectory and early predictors of apathy development in first-episode psychosis and healthy controls: a 10-year follow-up study

Lyngstad

Gardsjord

Engen

et al. 2020

Eur Arch Psychiatry Clin Neurosci

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“…Suicide is a major cause of death in patients with schizophrenia, and the risk of suicide among patients with schizophrenia is consistently almost 20 times higher than that in the general population (Kim et al, 2010;Nordentoft et al, 2004). In particular, individuals with first-episode psychosis have a greater risk of suicidal behaviour compared with those with chronic disorders (Bertelsen et al, 2007;Coentre et al, 2017). In particular, the first 12 months after a first episode of psychosis is the time of highest risk for completed suicide, and it is clear that this risk extends for up to 5 years (Dutta et al, 2010;McGinty et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

“…Comorbid depression is common from the first episode of psychosis (Upthegrove et al, 2010). The prevalence of depression in patients with first-episode non-affective psychosis is 14% to 41% with an average rate of about 25%, which is higher than that of the general population (Coentre, Talina, Gois, & Figueira, 2017;Cotton et al, 2012;Sönmez et al, 2016). Furthermore, it is important to evaluate and manage comorbid depressive symptoms adequately as they are associated with extended hospitalization, higher relapse rates, poorer social functioning, and an increased risk of suicide (Addington & Addington, 1992;Hausmann & Fleischhacker, 2002;Kim, Shin, Kim, Lee, et al, 2007a;Kim, Shin, Kim, Yoo, et al, 2007b;Yoo et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, it is important to evaluate and manage comorbid depressive symptoms adequately as they are associated with extended hospitalization, higher relapse rates, poorer social functioning, and an increased risk of suicide (Addington & Addington, 1992;Hausmann & Fleischhacker, 2002;Kim, Shin, Kim, Lee, et al, 2007a;Kim, Shin, Kim, Yoo, et al, 2007b;Yoo et al, 2015). Depressive symptoms can occur during different phases of psychosis (Coentre et al, 2017). Although earlier studies suggested that depressive symptoms predict better treatment outcome (Stephens, Astrup, & Mangrum, 1966), this is not supported by more recent research findings (Conley, Ascher-Svanum, Zhu, Faries, & Kinon, 2007;Gardsjord et al, 2016;McGinty, Sayeed Haque, & Upthegrove, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Clinical and psychosocial factors associated with depression in patients with psychosis according to stage of illness

Kim

Lee

et al. 2019

Early Intervention Psych

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Aim: This study investigated the clinical characteristics and psychosocial factors associated with depression in patients with early psychosis according to stage of illness.Methods: The present study includes patients who fulfil the DSM-5 criteria for schizophrenia spectrum and other psychotic disorders. Patients were divided into two groups according to illness stage (the acute stage of first-episode psychosis and stabilization phase of recent-onset psychosis). Clinically meaningful depression was defined as moderate or severe on the depression dimension of the Clinician-Rated Dimensions of Psychosis Symptom Severity scale in the DSM-5. Results: In total, 340 (207 first-episode and 133 recent-onset) patients were recruited in this study. Patients with comorbid depression were characterized by frequent suicidal ideation, a past suicide attempt, and lower scores on the Subjective Well-being Under Neuroleptics and Brief Resilience Scale in both groups. Long duration of untreated psychosis and higher scores on the Early Trauma Inventory Self Report were associated with depression in the acute stage of first-episode psychosis. In the stabilization phase of recent-onset psychosis group, a monthly income and scores for sexual desire and on the Family Adaptability and Cohesion Evaluation Scale-III were significantly lower in patients with depression than in those without depression. Conclusion: Comorbid depression was associated with high suicidality, lower quality of life and poor resilience in patients with first-episode and recent-onset psychosis. Depression was associated with factors that had been present before the initiation of treatment in patients with firstepisode psychosis and with environmental factors in those in the stabilization phase. K E Y W O R D S cohort, depression, first-episode psychosis, schizophrenia, suicide

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“…Studies have also reported on its economic burden 10–12. The cost of depression is high, and it is associated with suicidal risk 13. Previous studies suggest that the use of healthcare services by depressed patients exceeds that of similar non-depressed patients by 50%–100% 14.…”

Section: Introductionmentioning

confidence: 99%

Healthcare utilisation for eating disorders among patients with depression: a cross-sectional study in Taiwan

et al. 2019

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ObjectivesAlthough depressed patients may have a comorbid eating disorder (ED), to date, no study has focused on healthcare utilisation among this population. This study was designed to investigate the characteristics of healthcare service utilisation among depressed patients with ED.DesignA cross-sectional study.SettingThis population-based study used claims data from Taiwan’s National Health Insurance Research database between 2001 and 2012.ParticipantsThe study involved 1270 participants. These included 254 depressed individuals with ED and 1016 propensity score-matched depressed individuals without ED.Outcome measuresWe tracked each patient for a 1 year period to evaluate their healthcare service utilisation, including outpatient visits, inpatient days, and costs for psychiatry and non-psychiatry services. We performed a Mann-Whitney U test to compare outcome variables in healthcare service utilisation between the two groups.ResultsPatients with both depression and ED had significantly more outpatient visits (32.2 vs 28.9, p=0.023), outpatient costs (US$1089 vs US$877, p<0.001) and total costs (US$1356 vs US$1296, p<0.001) than comparison patients. For psychiatric services, patients with depression and ED had more outpatient visits (11.0 vs 6.8, p<0.001), outpatient costs (US$584 vs US$320, p<0.001) and total costs (US$657 vs US$568, p<0.001) than those without ED. For non-psychiatric services, there was no significant difference for all utilisation. This indicates that the total costs were about 1.0-fold greater for depression patient with ED than those without ED.ConclusionDepression patients with ED had more outpatient visits, outpatient costs and total costs of healthcare services than those without ED.

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Depressive symptoms and suicidal behavior after first-episode psychosis: A comprehensive systematic review

Cited by 71 publications

References 33 publications

Trajectory and early predictors of apathy development in first-episode psychosis and healthy controls: a 10-year follow-up study

Trajectory and early predictors of apathy development in first-episode psychosis and healthy controls: a 10-year follow-up study

Clinical and psychosocial factors associated with depression in patients with psychosis according to stage of illness

Healthcare utilisation for eating disorders among patients with depression: a cross-sectional study in Taiwan

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