Depressive symptoms and their relationship with negative and other psychotic symptoms in early onset psychosis

Calderon-Mediavilla, María; Araya, S; Arteaga, María Verónica Muñoz; Asensio, R Pérez; Autonell, J; Baños, Iris; Bañuelos, M.; Barajas, Ana; Barceló, Marta; Blanc, Michel; Borràs, Miquel; Busquets, Ester; Carlson, Janina; Carral, Vanessa; Castro, Elena; Corbacho, Casimiro; Dachs, I.; Miquel, L.; Domenech, M. D.; Elias, Maria Cristina; Espezel, I.; Falo, E.; Fargas, Arnau; Fusté, Montserrat; Godrid, M.; Gómez, David; González, Olga Molinero; Granell, Luis; Gumà, L.; Haro, Josep María; Herrera, Sávia Denise Silva Carlotto; Huerta, Elena; Lacasa, Fernando; Mas, Nuria de; L, Martí; Martinez, R. Gomez; Matalí, Josep Lluís; Muñoz, Daniel; Muñoz, Verónica Pérez; Nogueroles, R.; Ortiz, José M.; Planella, Marià Monzó; Peruzzi, S; Portos, J.; Rivero, S; Rubio, E.; Sammut, S.; Sánchez, Mónica Delgado; Sánchez, Bernardo; Serrano, E.; Solis, C. V.; Stephan‐Otto, Christian; Tabuenca, Patricia García; Torres, Anna; Urbano, David; Vilaplana, Míriam; Villalta, Victoria; Ahicart, A.; Álvarez, Mar; Arranz, Belén; Barneda, V.; Bogas, J.L.; Bonilla, Rosalba Rosales; Butjosa, Anna; Casali, T.; Colomer, Belén Fernández; Coromina, Marta; Cuautle, A.; Cuevas‐Esteban, Jorge; Cunill, Ruth; Cuñat, O.; Cacho, N. Del; Hoyo, B. del; Delisau, Y.; Dolz, Montse; Ferrer, I.; Foix, Alexandrina; Grases, N.; Iglesias-González, María; Ledesma-Ipaguirre, G.; López-Ortiz, Cristina; Membrive, P.; Miñambres, Aitor; Muñoz-Samons, Daniel; Ochoa, Susana; Pastrana, N.; Rodríguez, María José Cubillas; Peláez, Trinidad; Saltó, C.; Sibelo, S.; Núñez, Christian; Núñez, Marian Amanda Vázquez; Pardo, Marta; Redin, J.; Aguileta, IRiera-Lopez de; Romans, C.; Rubio‐Abadal, Elena; Santos, Anemari Ramos Dinarte dos; Sole, L.; Soler, A.; Teba, S.; Usall, Judith; Vila‐Badia, Regina

doi:10.1007/s00787-020-01618-0

Cited by 13 publications

(6 citation statements)

References 34 publications

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“…It also supports the idea that some patients develop a poorer outcome via an affective pathway (Alameda et al, 2020; Alameda, Conus, Ramain, Solida, & Golay, 2022; van Os et al, 2020). Contrary to previous studies (Alameda et al, 2022; Calderon-Mediavilla et al, 2021), we did not observe a significant association between depressive symptoms and psychotic symptomatology. However, to our knowledge, this is the first study that investigated the co-occurrence of manic and depressive dimensions in early psychosis, considering the impact of the relative expression of both dimensions at the same time, rather than separately.…”

Section: Discussioncontrasting

confidence: 99%

The co-occurrence of manic and depressive dimensions in early psychosis: a latent transition analysis

et al. 2023

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Background Frequently associated with early psychosis, depressive and manic dimensions may play an important role in its course and outcome. While manic and depressive symptoms can alternate and co-occur, most of the studies in early intervention investigated these symptoms independently. The aim of this study was therefore to explore the co-occurrence of manic and depressive dimensions, their evolution and impact on outcomes. Methods We prospectively studied first-episode psychosis patients (N = 313) within an early intervention program over 3 years. Based on latent transition analysis, we identified sub-groups of patients with different mood profiles considering both manic and depressive dimensions, and studied their outcomes. Results Our results revealed six different mood profiles at program entry and after 1.5 years follow-up (absence of mood disturbance, co-occurrence, mild depressive, severe depressive, manic and hypomanic), and four after 3 years (absence of mood disturbance, co-occurrence, mild depressive and hypomanic). Patients with absence of mood disturbance at discharge had better outcomes. All patients with co-occurring symptoms at program entry remained symptomatic at discharge. Patients with mild depressive symptoms were less likely to return to premorbid functional level at discharge than the other subgroups. Patients displaying a depressive component had poorer quality of physical and psychological health at discharge. Conclusions Our results confirm the major role played by mood dimensions in early psychosis, and show that profiles with co-occurring manic and depressive dimensions are at risk of poorer outcome. An accurate assessment and treatment of these dimensions in people with early psychosis is crucial.

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Section: Discussioncontrasting

confidence: 99%

The co-occurrence of manic and depressive dimensions in early psychosis: a latent transition analysis

et al. 2023

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“…We found that patients without depressive symptoms performed lower on the PANSS total score and general subscore than patients with depressive symptoms. Additionally, we observed no difference in the positive subscore between the groups of patients, which is consistent with Calderon-Mediavilla’s previous study ( 61 ). There was also no difference in the negative subscore.…”

Section: Discussionsupporting

confidence: 93%

Association Between Depressive Symptoms and Serum Brain-Derived Neurotrophic Factor Levels in Patients With First-Episode and Drug-Naïve Schizophrenia

Yang

et al. 2022

Front. Psychiatry

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Previous studies have revealed that brain-derived neurotrophic factor (BDNF) levels are inversely associated with the severity of depressive symptoms. In addition, serum BDNF levels tend to increase with improvement in depressive symptoms. There is also evidence that BDNF has a possible role in the pathophysiology of schizophrenia. Therefore, the purpose of this study was to determine whether BDNF levels correlated with depressive symptoms in patients with first-episode and drug-naïve (FEDN) schizophrenia. In this study, 90 patients with FEDN schizophrenia and 60 healthy controls were recruited. The Positive and Negative Syndrome Scale (PANSS) and the 17-item Hamilton Depression Scale (HAMD-17) were used to gage psychopathological and depressive symptoms, respectively. All participants had their BDNF levels measured using a sandwich enzyme-linked immunosorbent test. Serum BDNF levels were lower in patients with FEDN schizophrenia compared with healthy controls. Moreover, patients with depressive symptoms exhibited a higher PANSS total score and a higher general psychopathology score than those without depressive symptoms (p < 0.05). For patients with depressive symptoms, serum BDNF levels were higher than in those without depressive symptoms (p < 0.05). An association between BDNF levels and the positive subscore was also observed (p < 0.01). However, there was no significant association between BDNF levels and HAMD scores (p > 0.05). In conclusion, BDNF levels were shown to be higher in the serum of patients with FEDN schizophrenia with depressive symptoms than in those without. Additionally, low levels of serum BDNF may contribute to the positive symptoms of FEDN schizophrenia but not to depressive symptoms.

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“…Moreover, the results on the relationships between self-reflectiveness/composite index and negative symptoms are consistent with previous studies. Several studies have reported that self-reflectiveness was closely associated with negative affect, such as depression and anxiety ( 43 , 46 , 48 – 51 ), which have strong associations with negative symptoms ( 52 – 54 ). Sagayadevan et al ( 55 ) also reported that psychiatric outpatients with higher self-reflectiveness scored higher on the environment domain but lower on the social relationships domain of quality of life.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Cognitive and Clinical Insight at Different Durations of Untreated Attenuated Psychotic Symptoms in High-Risk Individuals

Zhang

Wang³

et al. 2021

Front. Psychiatry

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Background: This study examines whether cognitive insight is impaired in high-risk individuals with attenuated psychotic symptoms (APS) and explores the relationship between cognitive and clinical insight at different durations of untreated attenuated psychotic symptoms (DUAPS).Methods: The Structured Interview for Psychosis high-risk Syndrome (SIPS) was used to identify APS individuals. APS (n = 121) and healthy control (HC, n = 87) subjects were asked to complete the Beck Cognitive Insight Scale (BCIS). Clinical insight of APS individuals was evaluated using the Schedule for Assessment of Insight (SAI). APS individuals were classified into four subgroups based on DUAPS, including 0–3, 4–6, 7–12, and >12 months. Power analysis for significant correlation was conducted using the WebPower package in R.Results: Compared with HC subjects, APS individuals showed poorer cognitive insight, with lower scores on BCIS self-reflectiveness and composite index (BCIS self-reflectiveness minus BCIS self-certainty). Only when DUAPS was longer than 12 months did the significant positive correlation between cognitive and clinical insight obtain the power about 0.8, including the associations between self-reflectiveness and awareness of illness, self-reflectiveness and the total clinical insight, and composite index and awareness of illness. The positive associations of composite index with awareness of illness within 0–3 months DUAPS and with the total score of SAI when DUAPS > 12 months were significant but failed to obtain satisfactory power.Conclusions: APS individuals may have impaired cognitive insight, demonstrating lower self-reflectiveness. The correlation between cognitive and clinical insight is associated with the duration of untreated attenuated psychotic symptoms.

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Depressive symptoms and their relationship with negative and other psychotic symptoms in early onset psychosis

Cited by 13 publications

References 34 publications

The co-occurrence of manic and depressive dimensions in early psychosis: a latent transition analysis

The co-occurrence of manic and depressive dimensions in early psychosis: a latent transition analysis

Association Between Depressive Symptoms and Serum Brain-Derived Neurotrophic Factor Levels in Patients With First-Episode and Drug-Naïve Schizophrenia

Relationship Between Cognitive and Clinical Insight at Different Durations of Untreated Attenuated Psychotic Symptoms in High-Risk Individuals

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