Depressive symptoms are a risk factor for all-cause mortality: results from a prospective population-based study among 3,080 cancer survivors from the PROFILES registry

Abstract

Paying more attention to the recognition and treatment of depressive symptoms seems warranted since depressive symptoms are often underdiagnosed and undertreated in cancer patients.

Morbidade Psicológica E Implicações Para a Recuperação De Adultos Após Cirurgia Oncológica

“…A depressão clínica é considerada o transtorno psiquiátrico mais prevalente entre pacientes com câncer e está associada com significativas perdas funcionais. Entretanto, é frequentemente subnotificada e não identificada até que seus impactos negativos sobre a qualidade de vida sejam graves (16,18) . Apesar da grande probabilidade de pessoas com câncer apresentarem morbidade psicológica, estudos relatam que os trabalhadores da saúde não conseguem identificar indivíduos com neoplasia maligna com sintomas de depressão e ansiedade, contribuindo para complicações no tratamento em mais da metade dos casos (2,6) .…”

Emotional Distress in Newly Diagnosed Cancer Outpatients: Do Depression and Anxiety Predict Mortality and Psychosocial Outcomes After 1 Year?

“…Complementing the findings by Sullivan and colleagues [14], results from a large prospective population study comprising mixed cancer patients (range 1 to 10 years after receiving a diagnosis of either endometrial cancer, colorectal cancer, lymphoma, or multiple myeloma) show that clinical depression (measured on the Hospital Anxiety and Depression Scale) was an independent predictor for all-cause mortality (Adjusted HR = 2.07. 95% CI 1.56 to 2.74, p<0.0001) [13].…”

“…Among these, persistent depression has been found to be associated with chronic pathophysiological effects (e.g. immunosuppression) [7], low health help-seeking behaviors [8], poor adherence to cancer treatment [9], and severe cognitive and functional impairments [10] -all of which could contribute to an increased risk of cancer mortality [11][12][13].…”

Breast cancer survivors. Early diagnosis – successful treatment – quality of life: multidisciplinary approach

“…As more research is completed with large cohorts that permit subgroup analyses and with longitudinal follow-up [50], there is an increasing recognition that psychological issues are primary concerns for cancer sur- For example, cohort studies show that compared with subjects with no histories of cancer, cancer survivors report higher rates of anxiety consistently; while some show higher rates of depression, and this has not been consistently demonstrated [55][56][57]. In addition, survivors who have clinical depression have a twofold risk of all-cause mortality [58]. Unfortunately, data suggest that we are not meeting these needs in cancer survivors as well as we should.…”