Depressive Symptoms Correlate with Disability and Disease Course in Multiple Sclerosis Patients: An Italian Multi-Center Study Using the Beck Depression Inventory

Solaro, Claudio; Trabucco, Erika; Signori, Alessio; Martinelli, Vittorio; Radaelli, Marta; Centonze, Diego; Rossi, Silvia; Grasso, Maria Grazia; Clemenzi, Alessandro; Bonavita, Simona; d’Ambrosio, Alessandro; Patti, Francesco; D’Amico, Emanuele; Cruccu, G.; Truini, Andrea

doi:10.1371/journal.pone.0160261

Cited by 53 publications

(31 citation statements)

References 42 publications

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“…Similar frequencies of depression have been found early after symptom onset: in an Australian multicentre cohort of people recruited soon after symptom onset (n = 236), the frequency of positive depressionscreen as measured by HADS was 16.0% (Simpson et al, 2016), greater disability associated with positive depression-screen. Studies of depression in MS using other depression screening tools have found similar results (Brown et al, 2009;Chwastiak et al, 2002;Solaro et al, 2016), with fatigue the most consistent determinant.…”

Section: Introductionmentioning

confidence: 62%

Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS

Simpson

Taylor

Jelinek

et al. 2019

Multiple Sclerosis and Related Disorders

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A B S T R A C TBackground: Depression is highly prevalent among people with MS, and determinants thereof would be useful. Objectives: We examined the relationship of demographic and clinical factors with positive depression-screen and change in depression over 2.5 years in people with MS. Methods: Positive depression-screen assessed by Patient Health Questionnaire (PHQ)-2 and PHQ-9. Associations of demographic and clinical factors with depression-screen and change thereof assessed using multivariable regression models, adjusted for age, sex, disability, fatigue, antidepressant use, and baseline PHQ-2, as appropriate. Results: Overweight/obese BMI, comorbidity number, fatigue, and disability were associated with positive depression-screen, while married/partnered state, being employed, higher perceived socioeconomic status, and greater education were inversely associated with depression-screen. After adjustment, only marital status, socioeconomic status, antidepressant medication use, and fatigue were associated with risk of newly positive depression-screen. MS type, relapse number and immunomodulatory medication use were not associated with depression-screen after controlling for disability and fatigue. Conclusion: In a large prospective cohort study of depression in people with MS, we substantiated several potential determinants of a positive depression-screen and depression trajectory, particularly fatigue. Given that fatigue is the most common and most significant clinical symptom for people with MS, efforts to reduce fatigue may have follow-on benefits for reducing depression.T the frequency of positive depression-screen increased by 7.3% per year of follow-up over 2.3 years, strongly predicted by disability (Wood et al., 2012). The BEYOND clinical trial (n = 891 with depression data) examined depression using the Beck Depression Inventory-II, finding an average frequency of positive depression-screen of 25-30%, not greatly varying over three years of follow-up (Schippling et al., 2016). Koch and colleagues followed a subgroup of 94/228 patients with baseline depression data for ten years, finding the proportion with clinically significant depression as measured by the Center for Epidemiologic Studies Depression Scale increased from 47.9% to 52.1% (Koch et al., 2008).While there are many cross-sectional studies examining mood and depression in MS, there is a comparative lack of prospective studies of change in depression in large representative samples. We undertook a prospective cohort study among an international sample of people living with MS followed over 2.5 years, examining the demographic and clinical characteristics of positive depression-screen at 2.5-year review, and of change in depression-screen during follow-up. Of note, the lifestyle determinants of depression-screen during this same period are described in another article . S. Simpson, et al.

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Section: Introductionmentioning

confidence: 62%

Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS

Simpson

Taylor

Jelinek

et al. 2019

Multiple Sclerosis and Related Disorders

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“…However, BDI was used widely in the selection of depressive symptoms in different groups of patients such as: psoriatic patients [30], multiple sclerosis [31,32], adolescents from dysfunctional families [33], high school adolescents [34], patients with dry eyes disease [35], in medical students [36], patients with coronary disease [37], patients with rheumatoid arthritis [38] etc.…”

Section: Discussionmentioning

confidence: 99%

BDI in the Assessment of Depression in Different Medical Conditions

Pop‐Jordanova

2017

Prilozi

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As a common disorder, depression must be diagnosed not only in psychiatric but also in different medical settings, especially in patients with chronic diseases. Beck Depression Inventory is valuable and sensitive self-report inventory used worldwide for assessment depressive symptoms. In this research we present obtained scores of BDI in different group of disorders and we showed that BDI scores are related to the clinical condition, as well as with the age.

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“…Prominent among diagnostic instruments is the long‐standing Beck Depression Inventory (BDI/BDI II; Beck, Ward, Mendelson, Mock, & Erbaugh, ; Beck & Steer, ) , and the more recent Beck Anxiety Inventory (BAI; Beck, Epstein, Brown, & Steer, ). Copious research evidence supports the view that both the BDI and BAI have robust utility in identifying patients with clinically significant anxiety and/or depression symptomatology in primary and acute care settings (Brown, Schulberg, & Madonia, ; Clark et al., ; Furlanetto, Mendlowicz, & Bueno, ; Gatchel & Schultz, ; Green, Brown, Jager‐Hyman, Steer, & Beck, ; Holtzheimer et al., ; Johnson, Neal, Brems, & Fisher, ; Lykouras et al., ; Manne et al., ; Novy, Nelson, Berry, & Averill, ; Piotrowski & Lubin, ; Reeves, Rohan, Langenberg, Snitker, & Postolache, ; Schneibel et al., ; Solaro et al., ; Strik, Honig, Lousberg, & Denollet, ; Wu, ). Yet, critiques claim that the Beck Inventories are “behavior‐based”, and thus, neglect the important domain areas such as cognitive and emotional factors (see Eack, Singer, & Greeno, ).…”

Section: Current Studymentioning

confidence: 93%

The status of the Beck inventories (BDI, BAI) in psychology training and practice: A major shift in clinical acceptance

Piotrowski

2017

J Appl Biobehavioral Res

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While the Beck Depression Inventory I and II (hereon BDI)have been a mainstay in mental health assessment for many decades, a cursory review of survey-based "test use" studies in the 1990s finds that the Beck Anxiety Inventory (BAI) was not initially a highly ranked test in the assessment of anxiety or psychopathology. To date, a review of the extant literature on the popularity of the Beck inventories in professional psychology training or practice settings has not been systematically analyzed, although Piotrowski and Gallant (Journal of Instructional Psychology, 36, 2009, 84) found the BAI the most visible anxiety scale in the research literature between 2000 and 2005. Yet, quite evident, the field of clinical assessment remains highly competitive with a proliferation of mental health scales and measures introduced, perennially, in both the professional and research literature. In addition, since the mid-1990s, regulatory restrictions (i.e., managed care directives) on the feasibility of providing multimethod assessment services has also been a potent headwind in professional practice. Thus, historically, the professional acceptance of the BDI and BAI remains somewhat opaque, in terms of degree of usage in both training and practice settings compared to other assessment instruments. Hence, the aim of the current study is to address this gap in the literature. To that end, the author identified, through an extensive literature review,

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Depressive Symptoms Correlate with Disability and Disease Course in Multiple Sclerosis Patients: An Italian Multi-Center Study Using the Beck Depression Inventory

Cited by 53 publications

References 42 publications

Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS

Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS

BDI in the Assessment of Depression in Different Medical Conditions

The status of the Beck inventories (BDI, BAI) in psychology training and practice: A major shift in clinical acceptance

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