Depressive symptoms during the first chemotherapy cycle predict mortality in patients with advanced non-small cell lung cancer

Chen, Mei‐Ling; Chen, Min-Chi; Yu, Chih-Teng

doi:10.1007/s00520-010-1005-8

Cited by 21 publications

(21 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our HR of 2.21 before adjustment is similar to other studies , which examine depression on mortality. After adjusting for age, performance status and cancer stage, our HR of 4.13 was more than twice as high, but this was comparable with another local study which found that cancer patients with depressive symptomology were 4.31 times more likely (than those without) to experience mortality.…”

Section: Discussionsupporting

confidence: 88%

Effects of depression and anxiety on mortality in a mixed cancer group: a longitudinal approach using standardised diagnostic interviews

et al. 2014

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 88%

Effects of depression and anxiety on mortality in a mixed cancer group: a longitudinal approach using standardised diagnostic interviews

et al. 2014

View full text Add to dashboard Cite

show abstract

“…26 Recent work demonstrated that interventions aimed at improving depressive severity and symptom control among those with NSCLC may also promote longer survival. 27 These interventions may be particularly beneficial for low SES individuals.…”

Section: Discussionmentioning

confidence: 99%

Socioeconomic Status Is Associated with Depressive Severity Among Patients with Advanced Non–Small-Cell Lung Cancer: Treatment Setting and Minority Status Do Not Make a Difference

Fagundes

Jones

Vichaya

et al. 2014

Journal of Thoracic Oncology

View full text Add to dashboard Cite

Introduction Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related morbidity and mortality. Unfortunately, patients with NSCLC have relatively poor survival rates compared with patients diagnosed with most other types of cancer. Accordingly, managing physical and mental health symptoms are important treatment goals. In the current investigation, we sought to determine whether individual socioeconomic status (SES; as indexed by level of education), racial/ethnic minority status, and hospital type (public vs. tertiary care center) were associated with NSCLC cancer patients’ depressive severity. Importantly, we investigated whether NSCLC patients’ individual SES was more or less prognostic of their depressive severity compared with minority status and the hospital context where they received treatment. Methods Patients scheduled for chemotherapy were assessed for depressed mood by the Beck Depression Inventory-II (BDI-II). Data were collected at baseline, and at approximately 6, 12, and 18 weeks. Results NSCLC patients with less education had more depressive severity than those with more education. Treatment setting and minority status were not associated with depressive severity. The interaction between education level and treatment setting predicting depressive severity was not significant suggesting that the association between education level and depressive severity did not differ by treatment setting. Conclusion Our study brings heightened awareness to the substantial, persistent SES differences that exist in depressive severity among late-stage NSCLC patients. Furthermore, these findings appear to persist regardless of minority status and whether the patient is treated at a public hospital or tertiary cancer center.

show abstract

“…In addition, lung cancer patients also have higher number of unmet psychological and daily living needs compared with patients with other malignancies . Despite the high prevalence, psychological distress remains largely unrecognized and suboptimally managed, which can lead to poorer quality of life, lower satisfaction with care, poorer adherence to treatment, and decreased survival …”

Section: Introductionmentioning

confidence: 99%

Assessing the psychosocial needs of newly diagnosed patients with nonsmall cell lung cancer: Identifying factors associated with distress

Leung¹,

Laskin

et al. 2019

Psycho-Oncology

View full text Add to dashboard Cite

Objective The Psychosocial Screen for Cancer (PSSCAN‐R) questionnaire is a validated screening tool used to identify the psychosocial needs of patients with cancer. It assesses patients' perceived social supports and psychosocial needs, and the presence of symptoms of depression and anxiety. The study goals were to assess the prevalence and factors associated with distress in patients with newly diagnosed nonsmall cell lung cancer (NSCLC). Methods All patients with NSCLC referred to BC Cancer centers from 2011 to 2015, who completed a prospective PSSCAN‐R questionnaire at the time of their first visit, were included in the study. Demographics and baseline disease characteristics were collected retrospectively. The chi‐squared test, Fisher exact test, and logistical regression analysis were used to compare factors associated with the presence of distress based on sex, age, stage of disease, and performance status (PS). Results A total of 4281 NSCLC patients completed the PSSCAN‐R questionnaire. Baseline characteristics: 70% were greater than or equal to 65, 50% female, 52% metastatic disease, 47% Eastern Cooperative Oncology Group (ECOG) greater than or equal to two. Patients who were female, less than 65, have metastatic disease and poor PS were more likely to report subclinical or clinical symptoms of anxiety. Symptoms of depression were associated with younger, female, poor PS patients, and social isolation. Conclusions Newly diagnosed patients with NSCLC are likely to report clinical symptoms of anxiety and depression and have a high number of concerns in multiple psychosocial domains. Resource development for lung cancer patients should be based on their care needs with careful consideration of patients' age, gender, stage, and social situation to optimally support their psychosocial needs during treatment and follow‐up.

show abstract

Depressive symptoms during the first chemotherapy cycle predict mortality in patients with advanced non-small cell lung cancer

Abstract: The finding supports that depressive symptoms at the early phase of treatment can predict shorter survival in patients with advanced NSCLC.

Cited by 21 publications

References 29 publications

Effects of depression and anxiety on mortality in a mixed cancer group: a longitudinal approach using standardised diagnostic interviews

Effects of depression and anxiety on mortality in a mixed cancer group: a longitudinal approach using standardised diagnostic interviews

Socioeconomic Status Is Associated with Depressive Severity Among Patients with Advanced Non–Small-Cell Lung Cancer: Treatment Setting and Minority Status Do Not Make a Difference

Assessing the psychosocial needs of newly diagnosed patients with nonsmall cell lung cancer: Identifying factors associated with distress

Contact Info

Product

Resources

About