Depressive Symptoms in Clinical and Incipient Alzheimer’s Disease

Hsiao, Julia J.; Teng, Edmond

doi:10.2217/nmt.13.10

Cited by 14 publications

(5 citation statements)

References 89 publications

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“…[73] Moreover, depressive symptoms have been shown to decrease with the development of AD. [74] One factor that has been shown to impact both mood and AD risk is diet. Nevertheless, the relationship between these three elements is incompletely understood.…”

Section: Study Title Reference Type Of Study Focus Findingsmentioning

confidence: 99%

The Relationship between Diet, Depression, and Alzheimer's Disease: A Narrative Review

Al Shamsi,

Rainey‐Smith,

Gardener

et al. 2024

Molecular Nutrition Food Res

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Purpose of ReviewThis narrative review evaluates the role of diet in the relationship between depression and Alzheimer's disease (AD).Recent FindingsAD and depression are often comorbid, and depression appears to independently increase the future risk of AD. Evidence suggests diet influences the risk of both conditions directly and indirectly. Diet impacts neurochemical and biological processes that may affect the development and progression of depression and cognitive dysfunction. The dietary components offering the greatest protection against depression and AD are yet to be determined. Current evidence highlights the importance of polyphenolic compounds, folate, B vitamins, and polyunsaturated fatty acids, along with adherence to dietary patterns like the Mediterranean diet, which includes multiple beneficial dietary factors.SummaryThe investigation of dietary factors in the prevention of depression and AD is a comparatively young field of research. Comprehensive highly characterised longitudinal datasets and advanced analytical approaches are required to further examine the complex relationship between diet, depression, and AD. There is a critical need for more research in this area to develop effective preventive strategies aimed at maintaining mental and physical health with advancing age.

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Section: Study Title Reference Type Of Study Focus Findingsmentioning

confidence: 99%

The Relationship between Diet, Depression, and Alzheimer's Disease: A Narrative Review

Al Shamsi,

Rainey‐Smith,

Gardener

et al. 2024

Molecular Nutrition Food Res

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“…According to previous studies, anxious-depressive-like behavior worked as both a predictor and a causal factor contributing to AD progression [9,289]. In clinical studies, AD patients had significantly increased anxious-depressive symptoms, and individuals with psychological distress or anxiety are more likely to be diagnosed with AD [289][290][291][292]. Moreover, anxious-depressive behaviors are closely related to extensive amyloid plaques and neurofibrillary tangles [9,290,293].…”

Section: Exercise Therapy For Ad Alleviates Learning and Memory Defic...mentioning

confidence: 99%

Therapeutic non-invasive brain treatments in Alzheimer’s disease: recent advances and challenges

Yang

Feng

et al. 2022

Inflamm Regener

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Alzheimer’s disease (AD) is one of the major neurodegenerative diseases and the most common form of dementia. Characterized by the loss of learning, memory, problem-solving, language, and other thinking abilities, AD exerts a detrimental effect on both patients’ and families’ quality of life. Although there have been significant advances in understanding the mechanism underlying the pathogenesis and progression of AD, there is no cure for AD. The failure of numerous molecular targeted pharmacologic clinical trials leads to an emerging research shift toward non-invasive therapies, especially multiple targeted non-invasive treatments. In this paper, we reviewed the advances of the most widely studied non-invasive therapies, including photobiomodulation (PBM), transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and exercise therapy. Firstly, we reviewed the pathological changes of AD and the challenges for AD studies. We then introduced these non-invasive therapies and discussed the factors that may affect the effects of these therapies. Additionally, we review the effects of these therapies and the possible mechanisms underlying these effects. Finally, we summarized the challenges of the non-invasive treatments in future AD studies and clinical applications. We concluded that it would be critical to understand the exact underlying mechanisms and find the optimal treatment parameters to improve the translational value of these non-invasive therapies. Moreover, the combined use of non-invasive treatments is also a promising research direction for future studies and sheds light on the future treatment or prevention of AD.

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“…Specifically, there is degeneration of the cholinergic basal forebrain in AD, which may reduce cholinergic tone, and this reduced tone may contribute to overall brain neuromodulation including that needed for mood regulation. Relatedly, it has been noted that MDD in AD is qualitatively different in some regard from depression in cognitively healthy and/or younger individuals, with AD-MDD individuals having more prominent motivational symptoms and less pronounced affective symptoms than MDD-alone individuals (Hsiao and Teng, 2013 ).…”

Section: Human Subjects Researchmentioning

confidence: 99%

Repurposing Cholinesterase Inhibitors as Antidepressants? Dose and Stress-Sensitivity May Be Critical to Opening Possibilities

Fitzgerald

Hale

Ghimire

et al. 2021

Front. Behav. Neurosci.

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When stress becomes chronic it can trigger lasting brain and behavioral changes including Major Depressive Disorder (MDD). There is conflicting evidence regarding whether acetylcholinesterase inhibitors (AChEIs) may have antidepressant properties. In a recent publication, we demonstrated a strong dose-dependency of the effect of AChEIs on antidepressant-related behavior in the mouse forced swim test: whereas the AChEI donepezil indeed promotes depression-like behavior at a high dose, it has antidepressant-like properties at lower doses in the same experiment. Our data therefore suggest a Janus-faced dose-response curve for donepezil in depression-related behavior. In this review, we investigate the mood-related properties of AChEIs in greater detail, focusing on both human and rodent studies. In fact, while there have been many studies showing pro-depressant activity by AChEIs and this is a major concept in the field, a variety of other studies in both humans and rodents show antidepressant effects. Our study was one of the first to systematically vary dose to include very low concentrations while measuring behavioral effects, potentially explaining the apparent disparate findings in the field. The possibility of antidepressant roles for AChEIs in rodents may provide hope for new depression treatments. Importantly, MDD is a psychosocial stress-linked disorder, and in rodents, stress is a major experimental manipulation for studying depression mechanisms, so an important future direction will be to determine the extent to which these depression-related effects are stress-sensitive. In sum, gaining a greater understanding of the potentially therapeutic mood-related effects of low dose AChEIs, both in rodent models and in human subjects, should be a prioritized topic in ongoing translational research.

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Depressive Symptoms in Clinical and Incipient Alzheimer’s Disease

Cited by 14 publications

References 89 publications

The Relationship between Diet, Depression, and Alzheimer's Disease: A Narrative Review

The Relationship between Diet, Depression, and Alzheimer's Disease: A Narrative Review

Therapeutic non-invasive brain treatments in Alzheimer’s disease: recent advances and challenges

Repurposing Cholinesterase Inhibitors as Antidepressants? Dose and Stress-Sensitivity May Be Critical to Opening Possibilities

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