Depressive Symptoms in Parkinson's Disease: A Comparison With Disabled Control Subjects

Ehmann, Tom; Beninger, Richard J.; Gawel, Marek; Riopelle, Richard J.

doi:10.1177/089198879000300102

Cited by 138 publications

(97 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some studies reported it as positive, while others showed no association. 2,17,19,36,38,49 Overall findings in relation to the prevalence and factors associated for depression in PD, are in keeping what is reported in Asia and western populations. This study showed some unique association of depression with PD such as higher daily dose of levodopa and predominantly involvement in right side.…”

Section: Discussionsupporting

confidence: 77%

“…9,43,44 Depending on diagnostic criteria used, the estimated prevalence of depression in PD has varied widely across studies, from 2.7% to more than 90%, with an average prevalence of about 30-40%. 3,[10][11][12][13]49 Despite this high prevalence, unfortunately, depression remains frequently under recognized and often undertreated. 14,38 Overlap between symptoms andsigns of depression, with those of PD, may mask diagnosing depression or PD in its early stages.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risk Factors of Major Depressive Disorder in Parkinson’s Disease

Khalil¹,

Rahman²,

Munira

et al. 2018

Bangladesh Med Res Counc Bull

View full text Add to dashboard Cite

Depression in idiopathic Parkinson's disease is highly prevalent that can significantly impair the quality of life. Its exact mechanism of development is still poorly understood. It is well studied in western population but data from Asia especially in the South Asian region is limited. Considering this, to identify the potential risk factors of depression, a cross-sectional study was conducted among Parkinson's disease patients attending a tertiary care hospital in Bangladesh between July 2013-June 2014, in the Department of Neurology, Shaheed Suhrawardy Medical College and Hospital in Dhaka, Bangladesh. One hundred thirty seven cases of Parkinson's disease were enrolled, based on UK Parkinson's Disease Society Brain Bank criteria. Brain MRI was done in all cases, and patients with aphasia, significant cognitive deficits, secondary Parkinsonism were excluded. The overall prevalence of depression in the study population was 42%. There were no significant differences in gender, residence, education, smoking and marital status. In univariate analysis, age≥70 years, un-employed, right side predominantly involved, disease duration ≥5 years, sleep disturbance, postural instability, dose of levodopa ≥500 mg/day, Hoehn and Yahr stage ≥III and moderate to severe disability were significantly associated with depressive disorder. Whereas in multivariate linear stepwise regression model, age ≥70 years, (p=0.044), right side predominant involvement (p<0.001); sleep disturbance (p=0.006) and dose of levodopa ≥500 mg/day (p<0.001) were the major risk factors for depressive disorder. A significant proportion of Parkinson's disease patients suffer from depression. It was identified that depression in Parkinson's disease was significantly associated with advancing age, predominate right side involvement, sleep disturbance and higher daily dose of levodopa.

show abstract

Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Risk Factors of Major Depressive Disorder in Parkinson’s Disease

Khalil¹,

Rahman²,

Munira

et al. 2018

Bangladesh Med Res Counc Bull

View full text Add to dashboard Cite

show abstract

“…Conversely, endogenous depression might occur as a result of the monoamine deficiency that characterizes PD. Patients with PD are more likely to be depressed than patients with other chronic disabling diseases, 721 and depression may predate the onset of motor symptoms. 722 In addition, both dopaminergic and noradrenergic innervation are reduced in several brain regions of depressed compared with nondepressed patients with PD.…”

Section: 668mentioning

confidence: 99%

The scientific and clinical basis for the treatment of Parkinson disease (2009)

Olanow¹,

Stern²,

Sethi³

2009

Neurology

771

658

View full text Add to dashboard Cite

Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many as 1-2% of persons aged 60 years and older. With the aging of the population, the frequency of PD is expected to increase dramatically in the coming decades. Current therapy is largely based on a dopamine replacement strategy, primarily using the dopamine precursor levodopa. However, chronic treatment is associated with the development of motor complications, and the disease is inexorably progressive. Further, advancing disease is associated with the emergence of features such as freezing, falling, and dementia which are not adequately controlled with dopaminergic therapies. Indeed, it is now appreciated that these nondopaminergic features are common and the major source of disability for patients with advanced disease. Many different therapeutic agents and treatment strategies have been evaluated over the past several years to try and address these unmet medical needs, and many promising approaches are currently being tested in the laboratory and in the clinic. As a result, there are now many new therapies and strategic approaches available for the treatment of the different stages of PD, with which the treating physician must be familiar in order to provide patients with optimal care. This monograph provides an overview of the management of PD patients, with an emphasis on pathophysiology, and the results of recent clinical trials. It is intended to provide physicians with an understanding of the different treatment options that are available for managing the different stages of the disease and the scientific rationale of the different approaches. 1 PD is the second most common neurodegenerative disorder, with an average age at onset of about 60 years. An estimated 5 million people throughout the world have PD, with 1 million individuals each in the United States and in Europe with the disorder. PD affects approximately 0.3% of the population and 1% to 2% of those older than 60 years.2 With the aging of the population and the substantial increase in the number of at-risk individuals older than 60 years, it is anticipated that the prevalence of PD will increase dramatically in the coming decades.

show abstract

“…The study was based on a follow-up of 132 cases, and outcome of the study presented a resourceful discussion on depression and disabilities in PD. In another study, the very similar notion of depressive behavior in PD was presented by comparing the equivalent disabilities in control subjects [80].…”

Section: Types Of Psychological Abnormalities Depressionmentioning

confidence: 99%

Cognitive and Psychological Anomalies in Parkinsons Disease: An Insight into Non-Motor Characteristic Features

Choudhury¹,

Rao²,

R³

et al. 2017

Neuropsychiatry

View full text Add to dashboard Cite

While most of the clinical concerns for Parkinson's disease (PD) are limited to the cardinal motor abnormalities, non-motor features like cognitive and psychological anomalies are also acquired ample of importance in last few decades. Progressive research has showcased several obvious incidences of cognitive and psychological anomalies in the pathophysiology of PD. It has been reported that, almost 30% PD sufferers show different degree of cognitive impairment but lack of awareness or negligence makes it difficult to diagnose it, at the initial stage of the disease. As a result, cognitive and psychological impairments continue to increases progressively and deteriorate the quality of life of the patient. It is presumable that, early detection of PD can be achieved by the identification of specific set of cognitive and psychological anomalies and the similar scope might open up new avenue in the non-invasive diagnosis of PD. In the present review, we have accumulated all the timely documentation on cognitive and psychological anomalies in PD and highlighted most of the non-motor features with rational justification for the relevance of their study in the early diagnosis of PD.

show abstract

Depressive Symptoms in Parkinson's Disease: A Comparison With Disabled Control Subjects

Cited by 138 publications

References 24 publications

Risk Factors of Major Depressive Disorder in Parkinson’s Disease

Risk Factors of Major Depressive Disorder in Parkinson’s Disease

The scientific and clinical basis for the treatment of Parkinson disease (2009)

Cognitive and Psychological Anomalies in Parkinsons Disease: An Insight into Non-Motor Characteristic Features

Contact Info

Product

Resources

About