Depressive symptoms in Parkinson's disease are related to reduced [123I]FP-CIT binding in the caudate nucleus

Abstract

These results suggest that depressive symptoms in PD are associated with dopamine loss in the caudate nucleus, possibly related to degeneration of dopaminergic projections from the ventral tegmental area, while motor symptoms are associated with low dopamine signalling to the putamen and loss of nigrostriatal projections. This is consistent with the neuroanatomy of partially segregated cortical-striatal-thalamocortical circuits and supports the role of dysfunctional associative and motivational circuits in PD-related depression.

Influence of depression in mild Parkinson's disease on longitudinal motor and cognitive function

“…While the pathophysiology of motor worsening among PD patients with early depression is not clear, there is evidence to demonstrate that depressive symptoms in PD are associated with dopamine loss in the caudate nucleus, likely related to degeneration of the dopaminergic projections from the ventral tegmentum. This loss of dopamine in the caudate, may likely influence dopamine signaling in the putamen and impair the cortical-striatal-thalamocortical circuits, hence the greater motor decline [26].…”

Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies

“…Of the 38 studies on depression, 33 reported findings from one single imaging modality: 19 used either PET [11, 12, 13,15, 16, 17, 18, 19] or SPECT 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30 techniques, four used T1‐weighted imaging 31, 32, 33, three used DTI 34, 35, 36, six used resting state functional MRI (RS‐FMRI) 37, 38, 39, 40, 41, 42 and two used TCS methods 43, 44. The remaining four of the 38 studies reported findings from structural T1‐weighted imaging plus another imaging method, including PET 14, DTI 45, task FMRI 46 and RS‐FMRI 47, respectively.…”

Compensatory fronto-parietal hyperactivation during set-shifting in unmedicated patients with Parkinson's disease

“…We used these scans to calculate the age-corrected DaT binding ratios in the dorsal-medial striatum (procedure and calculation described elsewhere) (Vriend et al, 2013). To gain further insight into the relation between task performance, task-related neural activation, and levels of striatal dopamine, we computed Spearman correlations between the binding ratios with the RTs of the correct repeat and shift trials, switch costs, and normalized switch costs, and with the extracted parameter estimates of the peak voxels from the group-by-task interaction effects.…”