The COVID‐19 pandemic has had a strong impact on adolescents worldwide. This special issue aimed to increase our understanding of the factors that explain interindividual differences in how adolescents are affected by the pandemic. The special issue includes 21 empirical articles from four continents on the role of the pandemic in changes in emotional, social, and academic adjustment during adolescence. The studies demonstrate that many adolescents experienced increased depressive symptoms, negative affect, and loneliness, and lower academic adjustment during the pandemic, particularly those that were already at risk before the pandemic. At the same time, many adolescents had individual, family, and community resources that made them resilient and helped them to continue to function well despite the adverse circumstances.