Depressive Symptoms, Pain, and Quality of Life among Patients with Nonalcohol-Related Chronic Pancreatitis

Balliet, Wendy; Edwards-Hampton, Shenelle A.; Borckardt, Jeffery J.; Morgan, Katherine A.; Adams, David B.; Owczarski, Stefanie M.; Madan, Alok; Galloway, Sarah; Serber, Eva R.; Malcolm, Robert

doi:10.1155/2012/978646

Cited by 34 publications

(32 citation statements)

References 28 publications

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“…Structured interviews of adults with CP have described significant impact on their physical, psychological, and social functioning (40). In adults with non-alcoholic pancreatitis, depression is common (41). Most concerning is the evidence of the negative effects of pain duration on cognitive performance in CP (42).…”

Section: Discussionmentioning

confidence: 99%

Direct Costs of Acute Recurrent and Chronic Pancreatitis in Children in the INSPPIRE Registry

Ting

Wilson

Schwarzenberg

et al. 2016

J. pediatr. gastroenterol. nutr.

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Objective To estimate selected direct medical care costs of children with chronic pancreatitis (CP) and acute recurrent pancreatitis (ARP). Methods We performed a cross-sectional study of data from INSPPIRE (International Study Group of Pediatric Pancreatitis: In search for a cuRE), a multinational registry of children with ARP or CP. We determined health care utilization and estimated costs of hospitalizations, surgical and endoscopic procedures, and medications in our study population. Health care utilization data were obtained from all subjects enrolled in the study, and costs were calculated using national United States costs. Results We included 224 subjects (median age 12.7 years), 42% of whom had CP. Mean number of hospitalizations, including for surgery and endoscopic retrograde cholangiopancreatography (ERCP), was 2.3/person/year, costing an estimated average $38,755/person/year. Including outpatient medications, estimated total mean cost was $40,589/person/year. Subjects utilizing surgical procedures or ERCP incurred mean annual costs of $42,951/person and $12,035/person, respectively. Estimated annual costs of pancreatic enzyme replacement therapy, diabetic medications, and pain medications were $4,114, $1,761, and $614 per person, respectively. In an exploratory analysis, patients with the following characteristics appear to accrue higher costs than those without them: more frequent ARP attacks/year, reported constant or episodic pain, family history of pancreatic cancer, and use of pain medication. Conclusions ARP and CP are uncommon childhood conditions. The severe burden of disease associated with these conditions and their chronicity results in high healthcare utilization and costs. Interventions that reduce the need for hospitalization could lower costs for these children and their families.

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Section: Discussionmentioning

confidence: 99%

Direct Costs of Acute Recurrent and Chronic Pancreatitis in Children in the INSPPIRE Registry

Ting

Wilson

Schwarzenberg

et al. 2016

J. pediatr. gastroenterol. nutr.

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“…Th e fourth subscale, however, is a unique feature of this instrument, which addresses issues of self-worth: overall health, economic health, body image, and stigma. Although it is not clear whether these quality of life issues are present in patients prior to the onset of the chronic pancreatitis or whether they are acquired issues that develop following the onset, it is clear that they are important concerns for these patients as demonstrated in numerous studies (5)(6)(7). Th eir inclusion in this instrument makes the PANQOLI more uniquely suited for the evaluation of quality of life in this group of patients than other generic quality of life instruments.…”

Section: Pancreas and Biliary Tractmentioning

confidence: 99%

“…In a survey conducted at four US centers on 111 chronic pancreatitis patients, 74% stated that their life was altered by their condition in a variety of ways: 60% reported a negative impact on their social lives, 43% reported a negative eff ect on their spouse/significant other relationships, and 63% were unemployed as a result of their condition ( 5 ). In another cross-sectional study conducted on 692 patients with chronic pancreatitis, patients with chronic pancreatitis had a 52% increase in depression symptoms using the Depression Scale (CESD) and a decrease in quality of life using the SF-12 in the physical and mental scores compared with the general population ( 6 ). Th ese fi ndings have been confi rmed from studies in Poland and the UK ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Pancreatitis Quality of Life Instrument: A Psychometric Evaluation

Wassef

DeWitt

McGreevy

et al. 2016

American Journal of Gastroenterology

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“…In the United European Gastroenterology evidence based guidelines for the diagnosis and therapy of CP (HaPanEU), quality of life including pain should be assessed through validated questionnaires (SF-12, SF-36, EORTC QLQ C-30, GIQLI). However, effort should be point at improvement of variable factors as psychological status, tobacco, alcohol consumption and nutritional deficiencies in respect to improve QoL and further to delay disease progression, using therapeutic education and physical rehabilitation, behavioral support and medication [6,99,[184][185][186][187][188][189][190].…”

Section: Quality Of Lifementioning

confidence: 99%

Up-To-Date View on the Clinical Manifestations and Complications of Chronic Pancreatitis

Kovacheva-Slavova¹,

Getsov²,

Vladimirov³

et al. 2019

Pancreatitis

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Chronic pancreatitis is an inflammatory disease that causes irreversible anatomical changes including infiltration of inflammatory cells, fibrosis and pancreatic calcification with destruction of the structure of the gland, leading to abdominal pain, endocrine and exocrine dysfunction. Pancreatic exocrine insufficiency (PEI) prevalence in chronic pancreatitis varies between 40 and 94%. PEI is diagnosed by direct and indirect tests. Nutritional status is assessed by anthropometric indicators; laboratory tests-hemoglobin, plasma proteins (albumin, prealbumin, retinol-binding protein, transferrin), fat-soluble vitamins A, D, E, K; micronutrients. Pancreatic enzyme replacement therapy (PERT) is a fundamental part of PEI treatment. An optimal PERT could prevent serious PEI complications such as metabolic bone disease, adverse cardiovascular events, cachexia, poor quality of life and mortality. A periodic screening for PEI complications with a respect to their primary and secondary prophylaxis is mandatory. Diabetes mellitus secondary to pancreatic disease is defined as pancreatogenic diabetes or type 3c diabetes mellitus. Patients with chronic pancreatitis are at increased risk for pancreatic cancer influenced by smoking, alcohol abuse, chronic inflammation and pancreatic stellate cells over-proliferation. However, chronic pancreatitis could be further complicated with splenic vein thrombosis, pseudocysts, duodenal or biliary obstruction, pseudoaneurysm and pancreatic duct stones which might require endoscopic or surgical treatment.

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Depressive Symptoms, Pain, and Quality of Life among Patients with Nonalcohol-Related Chronic Pancreatitis

Cited by 34 publications

References 28 publications

Direct Costs of Acute Recurrent and Chronic Pancreatitis in Children in the INSPPIRE Registry

Direct Costs of Acute Recurrent and Chronic Pancreatitis in Children in the INSPPIRE Registry

Pancreatitis Quality of Life Instrument: A Psychometric Evaluation

Up-To-Date View on the Clinical Manifestations and Complications of Chronic Pancreatitis

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