Depressive Symptoms, Race, and Glucose Concentrations

Boyle, Stephen H.; Georgiades, Anastasia; Brummett, Beverly H.; Helms, Michael J.; Williams, Redford B.; Barefoot, John C.

doi:10.2337/dc07-0258

Cited by 38 publications

(33 citation statements)

References 25 publications

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“…Data from civilian women suggest that while controlling for depression attenuates the relationship between PTSD and CVD, women with PTSD still suffer from higher rates of CVD (22). Concordant with data on CVD, available evidence links depression with elevated levels of blood glucose (159, 178, 179) and risk of diabetes (180, 181). Therefore, it is important that research on the relationships between PTSD and cardiovascular/metabolic disease address the issue of comorbid depression.…”

Section: Influences Of Hostility and Health Behaviors On Cardiovasculmentioning

confidence: 65%

Posttraumatic Stress Disorder, Cardiovascular, and Metabolic Disease: A Review of the Evidence

et al. 2010

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Background Posttraumatic stress disorder (PTSD) is a significant risk factor for cardiovascular and metabolic disease. Purpose The purpose of the current review is to evaluate the evidence suggesting that PTSD increases cardiovascular and metabolic risk factors, and to identify possible biomarkers and psychosocial characteristics and behavioral variables that are associated with these outcomes. Methods A systematic literature search in the period of 2002–2009 for PTSD, cardiovascular disease, and metabolic disease was conducted. Results The literature search yielded 78 studies on PTSD and cardiovascular/metabolic disease and biomarkers. Conclusions Although the available literature suggests an association of PTSD with cardiovascular disease and biomarkers, further research must consider potential confounds, incorporate longitudinal designs, and conduct careful PTSD assessments in diverse samples to address gaps in the research literature. Research on metabolic disease and biomarkers suggests an association with PTSD, but has not progressed as far as the cardiovascular research.

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Section: Influences Of Hostility and Health Behaviors On Cardiovasculmentioning

confidence: 65%

Posttraumatic Stress Disorder, Cardiovascular, and Metabolic Disease: A Review of the Evidence

et al. 2010

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“…The clustering of these factors is called the metabolic syndrome, and may be at least partially due to dysregulation of the neuroendocrine system (Rosmond, 2005; Walker, 2006; Anagnostis et al, 2009). To date, studies investigating the relationship between cortisol and the metabolic syndrome have yielded mixed results, with some studies showing an association with hypercortisolism (Steptoe et al, 2004; Boyle et al, 2007; Vogelzangs and Penninx, 2007; Weigensberg et al, 2008; Stalder et al, 2013), some showing hypocortisolism (Bengtsson et al, 2010; Ljung et al, 2012; Champaneri et al, 2013) and some showing no association (Filipovský et al, 1996; Rosmond, 2005; Walker, 2006; Anagnostis et al, 2009; Abraham et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

“…Due to the complex interplay between stress, cortisol and the development of the metabolic syndrome, reducing stress and cortisol has been identified as a potential treatment target for the metabolic syndrome (Steptoe et al, 2004; Walker, 2006; Boyle et al, 2007; Vogelzangs and Penninx, 2007; Weigensberg et al, 2008; Tamashiro et al, 2011; Stalder et al, 2013). Mind-body therapies may aid in this process (Bengtsson et al, 2010; Woodyard, 2011; Ljung et al, 2012; Champaneri et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effect of restorative yoga vs. stretching on diurnal cortisol dynamics and psychosocial outcomes in individuals with the metabolic syndrome: The PRYSMS randomized controlled trial

Corey

Epel

Schembri

et al. 2014

Psychoneuroendocrinology

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Purpose Chronic stimulation and dysregulation of the neuroendocrine system by stress may cause metabolic abnormalities. We estimated how much cortisol and psychosocial outcomes improved with a restorative yoga (relaxation) versus a low impact stretching intervention for individuals with the metabolic syndrome. Methods We conducted a 1-year multi-center randomized controlled trial (6-month intervention and 6-month maintenance phase) of restorative yoga vs. stretching. Participants completed surveys to assess depression, social support, positive affect, and stress at baseline, 6 months and 12 months. For each assessment, we collected saliva at four points daily for three days and collected response to dexamethasone on the fourth day for analysis of diurnal cortisol dynamics. We analyzed our data using multivariate regression models, controlling for study site, medications (antidepressants, hormone therapy), body mass index, and baseline cortisol values. Results Psychosocial outcome measures were available for 171 study participants at baseline, 140 at 6 months, and 132 at the 1 year. Complete cortisol data were available for 136 of 171 study participants (72 in restorative yoga and 64 in stretching) and were only available at baseline and 6 months. At 6 months, the stretching group had decreased cortisol at waking and bedtime compared to the restorative yoga group, The pattern of changes in stress mirrored this improvement, with the stretching group showing reductions in chronic stress severity and perseverative thoughts about their stress. Perceived stress decreased by 1.5 points (−0.4; 3.3, p=0.11) at 6 months, and by 2.0 points (0.1; 3.9, p=0.04) at 1 year in the stretching compared to restorative yoga groups. Post hoc analyses suggest that in the stretching group only, perceived increases in social support (particularly feelings of belonging), but not changes in stress were related to improved cortisol dynamics. Conclusions We found significant decreases in salivary cortisol, chronic stress severity, and stress perception in the stretching group compared to the restorative yoga group. Group support during the interactive stretch classes may have contributed to these changes.

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“…Increased stress in daily life is associated with a higher cortisol awakening response and higher mean day and evening cortisol levels (Kumari et al, 2010). Increased HPA activation by stress has been implicated in the impact of stress on the pathogenesis of the metabolic syndrome (Rosmond, 2005), and elevated cortisol levels has been shown to play a role in mediating the association between depressive symptoms and elevated blood glucose levels (Boyle et al, 2007). Recent prospective studies provide direct evidence for a causal role in that glucocorticoid excess predicts increased cardiovascular disease (CVD) incidence (Davey-Smith et al, 2005; Rosmond et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Cortisol responses to emotional stress in men: Association with a functional polymorphism in the 5HTR2C gene

Brummett

Kuhn

Boyle

et al. 2012

Biological Psychology

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The serotonin 5HTR2C receptor has been shown to mediate HPA axis activation during stress. We hypothesized that a functional polymorphism (rs6318) of the 5HTR2C gene would be associated with HPA axis response to a laboratory stress protocol. The present sample consisted of 41 men (22 African Americans, 19 Caucasians). We found that at rest men with the more active rs6318 Ser23 C allele had similar cortisol values compared to those with the less active sys23 G allele. During laboratory stress, however, men with the Ser23 C allele exhibited the predicted significantly higher cortisol levels (p < .001), as well as larger increases in anger (P=0.08) and depressive mood (P=0.006) ratings, compared to the sys23 G carriers. The increase in cortisol was significantly related to the increases in ratings of anger and depression assessed before and after the emotion induction, and these correlations became nonsignificant when rs6318 genotype was covaried. We conclude that genetic variation in 5HTR2C may be associated with HPA axis activation and stimulated by emotional stress, and also with both psychological and physiological endophenotypes that increase the risk of cardiovascular disease and type 2 diabetes.

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Depressive Symptoms, Race, and Glucose Concentrations

Cited by 38 publications

References 25 publications

Posttraumatic Stress Disorder, Cardiovascular, and Metabolic Disease: A Review of the Evidence

Posttraumatic Stress Disorder, Cardiovascular, and Metabolic Disease: A Review of the Evidence

Effect of restorative yoga vs. stretching on diurnal cortisol dynamics and psychosocial outcomes in individuals with the metabolic syndrome: The PRYSMS randomized controlled trial

Cortisol responses to emotional stress in men: Association with a functional polymorphism in the 5HTR2C gene

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