Deprotonation and protonation of humic acids as a strategy for the technological development of pH-responsive nanoparticles with fungicidal potential

Motta, Fernanda Lopes; Santana, M. H. A.

doi:10.1016/j.nbt.2016.07.003

Cited by 19 publications

(7 citation statements)

References 26 publications

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“…Predominance of these functional groups, for each case, was verified by 13 C-NMR analysis as shown in Figure 2A. The aliphatic, aromatic, and carboxyl groups can be identified in the regions 0-50, 108-165, and 165-190 ppm, respectively [35].…”

Section: Ftir and 13 C-nmr Spectra Of The Tested Humic Acidsmentioning

confidence: 77%

Polycyclic Aromatic Hydrocarbon Sorption by Functionalized Humic Acids Immobilized in Micro- and Nano-Zeolites

et al. 2021

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Polycyclic aromatic hydrocarbons (PAHs) are hazardous compounds originating from anthropogenic activity. Due to their carcinogenic properties for humans, several technologies have been developed for PAH removal. Sorption with natural and organic materials is currently one of the most studied due to its low cost and its environmentally friendly nature. In this work, a hybrid sorbent involving functionalized humic acids (HAs) and nano-zeolite is proposed to entrap PAHs. The use of functionalized HAs immobilized in a porous support is designed to address the instability of HAs in solution, which has been already reported. HA functionalization was carried out to increase the non-polarity of HAs and aliphatic group formation. The HAs were functionalized by esterification/etherification with alkyl halides, and their chemical changes were verified by FTIR and NMR. The sorption isotherms of the functionalized HAs in micro- and nano-zeolites were used to assess the performance of the nano-zeolites in adsorbing these HAs. The hybrid support allowed the removal of anthracene and pyrene at percentages higher than 90%; fluoranthene, of angular molecular structure, was adsorbed at 85%. PAHs are ubiquitous in the environment, and a stable sorption of them in solid matrices will allow their removal from the environment through effective and environmentally friendly methods.

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Section: Ftir and 13 C-nmr Spectra Of The Tested Humic Acidsmentioning

confidence: 77%

Polycyclic Aromatic Hydrocarbon Sorption by Functionalized Humic Acids Immobilized in Micro- and Nano-Zeolites

et al. 2021

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“…Under neutral conditions, the charge of the PCN-777 disappeared due to deprotonation and the drug was released in large quantities. [36][37][38][39][40] Jiang et al, [41] took advantage of this mechanism to design and synthesize a Zr-based MOF ZJU-802. ZJU-802 had a high anionic drug loading capacity (> 40 %), and its loaded anionic drug was easily released at pH 7.4, while at pH 2.0, due to the enhanced hostguest interaction between the MOF and anionic drug, release was negligible.…”

Section: Drug Release Of Ibuna@pcn-777mentioning

confidence: 99%

A pH‐responsive Zr‐based metal organic framework PCN‐777 as a potential oral drug carrier

Jiang

et al. 2023

Zeitschrift anorg allge chemie

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A Zr‐based metal‐organic framework PCN‐777 with good biocompatibility was synthesized by solvothermal method using 2,4,6‐Tris(4‐Carboxyphenyl)‐1,3,5‐Triazine and ZrOCl2 ⋅ 8H2O as raw materials. Its structure was identified and the results showed that it had good crystallinity. Then the anti‐inflammatory drug ibuprofen sodium was loaded into PCN‐777 to establish an IBUNa@PCN‐777 compound and the maximum loading capacity was tested. When the mass ratio of IBUNa to PCN‐777 was 4 : 1, the loading of IBUNa in IBUNa@PCN‐777 reached the maximum value 72.53 wt %. Biocompatibility investigation indicated PCN‐777 and IBUNa@PCN‐777 had good biocompatibility. Moreover, the drug release behavior of IBUNa@PCN‐777 testified the drug release at pH 7.4(>80 %) was greater than that at pH 2.0(<20 %). indicated that IBUNa@PCN‐777 had good pH response in simulated digestive environments. The above results demonstrated that PCN‐777 had potential application prospects as an oral drug carrier.

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“…8,9,31 During bioremediation, the oxygen content increased from 23.23 to 27.97 %, the calculated O/C ratio increased from 0.28 to 0.35 and the E 4 /E 6 ratio increased from 2.25 to 3.91, which indicates enrichment of HAs with oxygen functional groups. 9,15,31,32 Table I also shows some comparative values extracted from published literature. They show significant variations in values, most likely due to the diversity in the structure of humic acids.…”

Section: Change In Tph Content and Number Of Microorganisms During Bimentioning

confidence: 99%

“…13 HAs are composed of quinone, phenolic, enolic and carboxylic acid functional groups, and as a result, they have numerous uses. 11,14,15 Scientific reports about soil and sediment humification are plentiful, but there is not enough data about the humification process during bioremediation and biodegradation. Since HAs are of vital importance for soil quality, their quantity should always be determined in bioremediation processes.…”

Section: Introductionmentioning

confidence: 99%

Evolution of humic acids during ex situ bioremediation on a pilot level: The added value of the microbial activity

Žerađanin

Avdalović

Lješević

et al. 2020

JSCS

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Environmental pollution is a global problem, while bioremediation technology removes pollutants from the environment using microorganisms. This study was aimed at investigating how a bioremediation process affected soil humification. In soil polluted with petroleum and its derivatives that was submitted to bioremediation, besides the total petroleum hydrocarbons and the number of microorganisms, quantitative and qualitative changes of isolated humic acids were determined during the process. The bioremediation of 150 m 3 of polluted soil lasted 150 days. The level of total petroleum hydrocarbons decreased by 86.6 %, while the level of humic acids increased by 26.5 %. The elemental analysis showed the reduction of C and the H/C ratio and the increase of O and the O/C ratio of isolated humic acids during the process. The ratio of absorbencies at 465 and 665 nm also increased. Based on this and the Fourier-transform infrared spectra, it was shown that the humic acids isolated at the end of bioremediation were enriched with oxygen functional groups and aromatic structures. This study provides one of the first insights into the relationship between bioremediation and humification, as well as evidence of how hydrocarbon-degrading microorganisms have a significant influence on changes to humic acid structure during bioremediation.

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Deprotonation and protonation of humic acids as a strategy for the technological development of pH-responsive nanoparticles with fungicidal potential

Cited by 19 publications

References 26 publications

Polycyclic Aromatic Hydrocarbon Sorption by Functionalized Humic Acids Immobilized in Micro- and Nano-Zeolites

Polycyclic Aromatic Hydrocarbon Sorption by Functionalized Humic Acids Immobilized in Micro- and Nano-Zeolites

A pH‐responsive Zr‐based metal organic framework PCN‐777 as a potential oral drug carrier

Evolution of humic acids during ex situ bioremediation on a pilot level: The added value of the microbial activity

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