Depth of invasion alone as an indication for postoperative radiotherapy in small oral squamous cell carcinomas: An International Collaborative Study

Ebrahimi, Ardalan; Gil, Ziv; Amit, Moran; Yen, Tzu Chen; Liao, Chun‐Ta; Chaturvedi, Pankaj; Agarwal, Jai Prakash; Kowalski, Luiz Paulo; Köhler, Hugo Fontan; Kreppel, Matthias; Cernea, Cláudio Roberto; Brandao, J. G. T.; Bachar, Gideon; Villaret, Andrea Bolzoni; Fliss, Dan M.; Fridman, Eran; Robbins, K. Thomas; Shah, Jatin P.; Patel, Snehal G.; Clark, Jonathan; Cancer, Neck

doi:10.1002/hed.25633

Cited by 40 publications

(34 citation statements)

References 30 publications

(93 reference statements)

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“…, the tumor DOI is not yet a criterion for radiation therapy for patients with cN0 (Ganly et al, ) . Accordingly, a recent multicenter study showed that DOI alone should not be indicative for postoperative radiotherapy in early‐stage OSCC in the absence of other adverse features (Ebrahimi et al, ).…”

Section: Discussionmentioning

confidence: 99%

Tumor depth of invasion and prognosis of early‐stage oral squamous cell carcinoma: A meta‐analysis

et al. 2019

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Objectives To assess the prognosis for early‐stage oral squamous cell carcinoma according to tumor depth of invasion (DOI). Methods This study was logged in the PROSPERO database under protocol # CRD42017059976. The search was conducted in six electronic databases up to May 2019. Fixed‐effects meta‐analysis was performed for the calculation of the odds ratio (OR) and respective 95% CI. Primary outcomes were lymph node metastasis, recurrence, and survival. Heterogeneity was calculated by the I2 test. The certainty of evidence was assessed by Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. Results Twenty‐seven studies were included (19 in the meta‐analysis) with 2,404 patients with a mean of 60 years of age. High tumor DOI is associated with a greater chance of presenting lymph node metastasis, regardless of the cutoff point for DOI (13 meta‐analysis; OR 1.69–53.08), recurrence (five meta‐analysis; OR 1.22–3.83), and lower chance of survival (1 meta‐analysis; OR 0.49). The certainty of evidence varied from very low to low. Conclusions Tumor DOI is a good prognosticator for early‐stage OSCC. The findings of the current meta‐analysis highlight the clinical relevance of DOI and corroborate its incorporation for staging OSCC.

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Section: Discussionmentioning

confidence: 99%

Tumor depth of invasion and prognosis of early‐stage oral squamous cell carcinoma: A meta‐analysis

et al. 2019

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“… 35 Moreover, in the absence of other adverse pathological features, DOI should not be an independent indication for postoperative radiotherapy in small OSCC. 36 With regard to the implementation of END, Akira Baba et al reported that oral tongue cancer undetectable on magnetic resonance imaging (MRI) indicated a high possibility of pathological DOI smaller than 4 mm, which can be used as a criterion to avoid unnecessary END in node-negative patients. 37 Nevertheless, MRI evidence of invasion to the styloglossus and hyoglossus muscles corresponds to a DOI greater than 4 mm, which can be a criterion for the advisability of END.…”

Section: Resultsmentioning

confidence: 99%

Research on neck dissection for oral squamous-cell carcinoma: a bibliometric analysis

Jiang

et al. 2021

Int J Oral Sci

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Neck dissection for oral squamous-cell carcinoma (OSCC) is a clinically controversial issue and has therefore been the subject of abundant research. However, no one has performed a bibliometric study on this topic to date. The aim of this study was to assess the development of research on neck dissection for OSCC in terms of the historical evolution, current hotspots and future directions, particularly including research trends and frontiers from 2010 to 2019. Literature records related to research on neck dissection for OSCC were retrieved from the Web of Science Core Collection (WoSCC). CiteSpace was used as a tool to perform a bibliometric analysis of this topic. The survey included 2 096 papers. “Otorhinolaryngology” was the most popular research area. The most active institutions and countries were Memorial Sloan Kettering Cancer Center and the USA, respectively. Shah J.P. was the most cited author. Among the six identified “core journals”, Head & Neck ranked first. The top three trending keywords were ‘invasion’, ‘upper aerodigestive’ and ‘negative neck’. ‘D’Cruz AK (2015)’ was the most cited and the strongest burst reference in the last decade. The study evaluated the effect on survival of elective versus therapeutic neck dissection in patients with lateralized early-stage OSCC. The depth of invasion and the management of N0 OSCC were research frontiers in this field. The present study provides a comprehensive bibliometric analysis of research on neck dissection for OSCC, which will assist investigators in exploring potential research directions.

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“…In contrast to the above findings, HDFs had little effect on the biological characteristics of OSCC. Cutaneous squamous cell carcinoma (CSCC) has a better prognosis than OSCC, and CSCC rarely invades deep into the skin tissue [ 15 , 16 , 17 ], whereas OSCC has significant invasion ability [ 18 ]. Although both CSCC and OSCC develop from the epithelium in a similar manner, their infiltration ability and prognosis are quite different.…”

Section: Discussionmentioning

confidence: 99%

The Origin of Stroma Influences the Biological Characteristics of Oral Squamous Cell Carcinoma

Omori

Shan

Takabatake

et al. 2021

Cancers

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Normal stromal cells surrounding the tumor parenchyma, such as the extracellular matrix (ECM), normal fibroblasts, mesenchymal stromal cells, and osteoblasts, play a significant role in the progression of cancers. However, the role of gingival and periodontal ligament tissue-derived stromal cells in OSCC progression is unclear. In this study, the effect of G-SCs and P-SCs on the differentiation, proliferation, invasion, and migration of OSCC cells in vitro was examined by Giemsa staining, Immunofluorescence (IF), (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) (MTS), invasion, and migration assays. Furthermore, the effect of G-SCs and P-SCs on the differentiation, proliferation, and bone invasion by OSCC cells in vivo was examined by hematoxylin-eosin (HE) staining, immunohistochemistry (IHC), and tartrate-resistant acid phosphatase (TRAP) staining, respectively. Finally, microarray data and bioinformatics analyses identified potential genes that caused the different effects of G-SCs and P-SCs on OSCC progression. The results showed that both G-SCs and P-SCs inhibited the differentiation and promoted the proliferation, invasion, and migration of OSCC in vitro and in vivo. In addition, genes, including CDK1, BUB1B, TOP2A, DLGAP5, BUB1, and CCNB2, are probably involved in causing the different effects of G-SCs and P-SCs on OSCC progression. Therefore, as a potential regulatory mechanism, both G-SCs and P-SCs can promote OSCC progression.

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Depth of invasion alone as an indication for postoperative radiotherapy in small oral squamous cell carcinomas: An International Collaborative Study

Cited by 40 publications

References 30 publications

Tumor depth of invasion and prognosis of early‐stage oral squamous cell carcinoma: A meta‐analysis

Tumor depth of invasion and prognosis of early‐stage oral squamous cell carcinoma: A meta‐analysis

Research on neck dissection for oral squamous-cell carcinoma: a bibliometric analysis

The Origin of Stroma Influences the Biological Characteristics of Oral Squamous Cell Carcinoma

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