Depth of invasion（DOI） introduced in UICC 8th T classification in tongue carcinoma

Harada, Hiroyuki; Tomioka, Hirofumi; Yokokawa, Masayuki; Nojima, Hitomi; Komiya, Ruri; Kayamori, Kou; Ikeda, Tohru; Kurabayashi, Tohru

doi:10.5981/jjhnc.45.1

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…To the best of our knowledge, this is the first study on MRI divided into “before biopsy” and “after incision biopsy”. Our prior study focusing on the period between 2006 and 2015 showed that r-DOI using MRI before biopsy best correlated with p-DOI 26 . The present study expanded on this by including a larger patient number and considering the width shrinkage rate during the preparation process of histopathological specimen.…”

Section: Discussionmentioning

confidence: 97%

MRI before biopsy correlates with depth of invasion corrected for shrinkage rate of the histopathological specimen in tongue carcinoma

Harada

Tomioka

Hirai

et al. 2021

Sci Rep

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The purpose of this study was to evaluate which radiological depth of invasion (r-DOI) measurement is the most concordant to clinical DOI (c-DOI) derived from correction for the shrinkage rate of the histopathological specimens. We retrospectively reviewed 128 patients with tongue carcinoma who had undergone glossectomy between 2006 and 2019. At first, the width shrinkage rate during formalin fixation and preparation process of histopathological specimens was evaluated. From the shrinking rates, a formula to calculate c-DOI from pathological DOI (p-DOI) was developed. The correlation between c-DOI and r-DOI was evaluated. The specimen shrinkage rate during the histopathological specimen preparation process was 10.3%. Based on that, we yielded the correct formula for c-DOI based on p-DOI and preparation shrinkage rate: c-DOI = p-DOI × 100/89.7. The regression equations for the association of c-DOI with r-DOI measured by ultrasound (n = 128), MRI before biopsy (n = 18), and MRI after biopsy (n = 110) were y = 1.12 * x + 0.21, y = 0.89 * x − 0.26, and y = 0.52 * x + 2.63, respectively, while the coefficients of determination were 0.664, 0.891, and 0.422, respectively. In conclusion, r-DOI using MRI before biopsy most strongly correlated with c-DOI.

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Section: Discussionmentioning

confidence: 97%

MRI before biopsy correlates with depth of invasion corrected for shrinkage rate of the histopathological specimen in tongue carcinoma

Harada

Tomioka

Hirai

et al. 2021

Sci Rep

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“…Currently, the cutoff values of the pDOI for cervical lymph node metastases vary from 3 mm [46] to 6 [47] mm. Because the specimen contraction rate at the time of pathological specimen preparation differs among institutions [48,49], establishing a standard is difficult. In this study, we found that the mean clinical tumor thickness was 3.9 mm, but the mean pathological tumor thickness of the resected tumors (n = 61) was 3.4 mm, indicating a mean difference of approximately 13% between the clinical and pathological findings.…”

Section: Discussionmentioning

confidence: 99%

A Study of the Prognostic Factors for Late Cervical Lymph Node Metastasis and Distant Metastasis in Patients with cT1-2N0 Tongue Cancer

Obayashi,

Koizumi,

Ito

et al. 2024

JCM

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Background: Early-stage tongue cancer has a good prognosis in general; however, high-risk patients with late cervical lymph node and distant metastases have a poor prognosis. Elective neck dissection and postoperative chemoradiotherapy are considered for these patients, although no clear criteria have been identified for their evaluation. Methods: This retrospective observational study aimed to determine the predictive factors for late cervical lymph node and distant metastases in 102 patients with cT1-2N0 tongue cancer. The data regarding the demographic characteristics, as well as the depth of invasion, tumor budding, histological grade, and tumor–stromal ratio, among other things, were extracted from medical records. Results: We found that the potential lymph node metastasis rate was 27.5%. The significant clinical predictors of late cervical lymph node metastasis were the tumor thickness and endophytic growth pattern and the significant histopathological factors were poorly and moderately differentiated tumors and ≥3 tumor buds. In addition, the prognostic factors for distant metastasis included ≥4 lymph node metastases, ≥7 tumor budding, and moderate and poor tumor differentiation. Conclusions: The usefulness of tumor budding as a predictor of metastasis for tongue cancer was suggested. The findings of this study can help establish the criteria for evaluating the metastasis risk and prognosis of patients with tongue cancers.

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Clinicopathological study on local recurrence of primary oral squamous cell carcinoma

et al. 2021

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Depth of invasion（DOI） introduced in UICC 8th T classification in tongue carcinoma

Cited by 3 publications

References 13 publications

MRI before biopsy correlates with depth of invasion corrected for shrinkage rate of the histopathological specimen in tongue carcinoma

MRI before biopsy correlates with depth of invasion corrected for shrinkage rate of the histopathological specimen in tongue carcinoma

A Study of the Prognostic Factors for Late Cervical Lymph Node Metastasis and Distant Metastasis in Patients with cT1-2N0 Tongue Cancer

Clinicopathological study on local recurrence of primary oral squamous cell carcinoma

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