Depth-resolved optimization of a real-time sensorless adaptive optics optical coherence tomography

Camino, Acner; Ng, Ringo; Huang, Joey; Guo, Yukun; Sui, Ni; Jia, Yali; Huang, David; Jian, Yifan

doi:10.1364/ol.390134

Cited by 33 publications

(15 citation statements)

References 17 publications

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“…for a 7-mm pupil diameter, the depth of focus is approximately ten times thinner than the retina [21], making focus position an essential step. If the merit function did not take into account the retinal layer of interest, the wavefront optimization would be biased to the photoreceptor layer [22], preventing high SNR FFOCT images of the inner retina. During each imaging session, SD-OCT B-scans are displayed in real-time, allowing the user to select the retinal layer of interest, where the coherence gate is then automatically positioned.…”

Section: Resultsmentioning

confidence: 99%

Adaptive-glasses wavefront sensorless full-field OCT for high-resolution retinal imaging over a wide field-of-view

Scholler,

Groux,

Grieve

et al. 2020

Preprint

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The highest three-dimensional (3D) resolution possible in in-vivo retinal imaging is achieved by combining optical coherence tomography (OCT) and adaptive optics (AO). However, this combination brings important limitations, such as small field-of-view and complex, cumbersome systems, preventing so far the translation of this technology from the research lab to clinics. In this Letter, we introduce an approach that avoids these limitations by using a multi-actuator adaptive lens just in front of the eye, in a technique we call the adaptive-glasses wavefront sensorless approach. We implemented this approach on our compact full-field OCT (FFOCT) retinal imager without increasing its footprint or optical complexity. The correction of ocular aberrations through the adaptive-glasses approach increased the FFOCT signal-tonoise ratio and enabled us to image different retinal layers with a 3D cellular resolution in a 5 • × 5 • field-of-view, without apparent anisoplanatism.

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Section: Resultsmentioning

confidence: 99%

Adaptive-glasses wavefront sensorless full-field OCT for high-resolution retinal imaging over a wide field-of-view

Scholler,

Groux,

Grieve

et al. 2020

Preprint

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“…In the sample arm, a reflective collimator (RC04APC-P01, Thorlabs Inc., USA) collimated the beam to a variable focus liquid lens (clear aperture = 3.9 mm, Corning, France) for autofocusing into different layers of the sample [8]. The 4 mm beam was then deflected by a pair of galvanometer scanners (Saturn 5B, Pangolin Laser Systems Inc., USA) to a 2× beam expander comprised of two pairs of visible achromatic doublet lenses, L1 and L2, that had effective focal lengths of 50 mm and 100 mm respectively (Fig.…”

Section: Methodsmentioning

confidence: 99%

Visible-light optical coherence microscopy for corneal imaging

Khan¹,

Neuhaus²,

Thaware³

et al. 2023

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII

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Corneal disease is the fifth leading cause of global blindless. Optical coherence tomography (OCT) for anterior imaging is extensively used due to its non-invasive and high-resolution volumetric imaging characteristics. Optical coherence microscopy (OCM) is a technical variation of OCT that can image the cornea with cellular resolution. Here, we demonstrate a visible-light OCM as a low-cost and easily reproducible system to visualize various corneal cellular structures such as epithelial cells, endothelial cells, keratocytes, and collagen bundles within stromal lamellae. The visible-light OCM was also used to study pressure changes in anterior segment human donor eyes. The system achieved an axial resolution of 12 μm in tissue over a 1.2 mm imaging depth, and a lateral resolution of 1.6 µm over a field of view of up to 750 μm × 750 μm.

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“…Sensorless AO (SAO) is another alternative to hardware-based AO-OCT that relies on the images’ properties rather than a wavefront sensor to ultimately measure and correct aberrations [ 56 ]. SAO optimization methods and algorithms include Zernike Mode Hill Climbing [ 57 ], stochastic parallel gradient descent [ 58 , 59 ], deep reinforcement learning [ 60 ], and others. SAO features have been tested to some extent in CAO models as well [ 58 , 61 ].…”

Section: Adaptive Optics (Ao) In Oct (Ao-oct)mentioning

confidence: 99%

Advances in Optical Coherence Tomography Imaging Technology and Techniques for Choroidal and Retinal Disorders

Ong

Zarnegar

Corradetti

et al. 2022

JCM

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Optical coherence tomography (OCT) imaging has played a pivotal role in the field of retina. This light-based, non-invasive imaging modality provides high-quality, cross-sectional analysis of the retina and has revolutionized the diagnosis and management of retinal and choroidal diseases. Since its introduction in the early 1990s, OCT technology has continued to advance to provide quicker acquisition times and higher resolution. In this manuscript, we discuss some of the most recent advances in OCT technology and techniques for choroidal and retinal diseases. The emerging innovations discussed include wide-field OCT, adaptive optics OCT, polarization sensitive OCT, full-field OCT, hand-held OCT, intraoperative OCT, at-home OCT, and more. The applications of these rising OCT systems and techniques will allow for a closer monitoring of chorioretinal diseases and treatment response, more robust analysis in basic science research, and further insights into surgical management. In addition, these innovations to optimize visualization of the choroid and retina offer a promising future for advancing our understanding of the pathophysiology of chorioretinal diseases.

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Depth-resolved optimization of a real-time sensorless adaptive optics optical coherence tomography

Cited by 33 publications

References 17 publications

Adaptive-glasses wavefront sensorless full-field OCT for high-resolution retinal imaging over a wide field-of-view

Adaptive-glasses wavefront sensorless full-field OCT for high-resolution retinal imaging over a wide field-of-view

Visible-light optical coherence microscopy for corneal imaging

Advances in Optical Coherence Tomography Imaging Technology and Techniques for Choroidal and Retinal Disorders

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