Depth-resolved simplified characterization of collagen depletion in dermis with polarization sensitive optical coherence tomography applicable to non-laboratory conditions

Tougbaev, Vitali; Eom, Tae Joong; Shin, Woojin; Lee, Yeung Lak; Yu, Bong-Ahn; Kee, Chul‐Sik; Ko, Do‐Kyeong; Lee, Jongmin

doi:10.1117/12.728190

Cited by 2 publications

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“…12,13 Here, we reveal the basic principle and consider in more detail the experimental verification of the specific solution proposed for such systems as well as mention the simplified algorithm for mapping birefringence of dermis through measurements of the depolarization ratio. 14…”

Section: Introductionmentioning

confidence: 99%

Quasi-holographic solution to polarization-sensitive optical coherence tomography acceptable to nonlaboratory applications

Tougbaev

Eom

et al. 2008

J. Biomed. Opt.

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Experimental proof-of-concept is presented for a quasi-holographic solution to polarization-sensitive optical coherence tomography (PS OCT). Due to decoupling between the reference and sample beams by polarization, the solution seems acceptable to acquisition and communication of optical data in the nonlaboratory environment. The nonlab environment implies uncontrollable disturbances, e.g., temperature changes and mechanical effects happening under shop testing in industry or routine examinations in common clinics and hospitals. For mapping the collagen-related depolarization ratio of light backscattered from the human dermis, a phenomenological model is evolved from the theory of light depolarization in crystalline polymers. The model yielded a simplified intensity-based estimation algorithm. The design concept and the model rely on a submillimeter tumor thickness as a proofed prognostic factor and an important criterion for complementary functional diagnostics of skin cancers in their early phase. Choice of the model is inspired by similarity of structural and optical properties between liquid-crystal collagen fibers in the dermis and birefringent crystalline lamellae in some polymer materials. The model gives a plausible interpretation of a peculiarity of cumulative birefringence in the abnormal skin dermis. Following a top-down approach to design, the authors attempt to contribute to bridging the gap between practitioners' concerns and academic studies.

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Section: Introductionmentioning

confidence: 99%

Quasi-holographic solution to polarization-sensitive optical coherence tomography acceptable to nonlaboratory applications

Tougbaev

Eom

et al. 2008

J. Biomed. Opt.

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Assessing Breast Cancer through Tumor Microenvironment Mapping of Collagen and Other Biomolecule Spectral Fingerprints─A Review

Chohan,

Biswas,

Wankhede

et al. 2024

ACS Sens.

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Breast cancer is a major challenge in the field of oncology, with around 2.3 million cases and around 670,000 deaths globally based on the GLOBOCAN 2022 data. Despite having advanced technologies, breast cancer remains the major type of cancer among women. This review highlights various collagen signatures and the role of different collagen types in breast tumor development, progression, and metastasis, along with the use of photoacoustic spectroscopy to offer insights into future cancer diagnostic applications without the need for surgery or other invasive techniques. Through mapping of the tumor microenvironment and spotlighting key components and their absorption wavelengths, we emphasize the need for extensive preclinical and clinical investigations.

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Depth-resolved simplified characterization of collagen depletion in dermis with polarization sensitive optical coherence tomography applicable to non-laboratory conditions

Cited by 2 publications

References 0 publications

Quasi-holographic solution to polarization-sensitive optical coherence tomography acceptable to nonlaboratory applications

Quasi-holographic solution to polarization-sensitive optical coherence tomography acceptable to nonlaboratory applications

Assessing Breast Cancer through Tumor Microenvironment Mapping of Collagen and Other Biomolecule Spectral Fingerprints─A Review

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