Depuration kinetics and tissue disposition of PFOA and PFOS in white leghorn chickens (Gallus gallus) administered by subcutaneous implantation

Yoo, Hah Young; Guruge, Keerthi S.; Yamanaka, Naoaki; Sato, Chihiro; Mikami, Osamu; Miyazaki, Shigeru; Yamashita, Nobuyoshi; Giesy, John P.

doi:10.1016/j.ecoenv.2007.09.007

Cited by 77 publications

(73 citation statements)

References 26 publications

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“…The crude nutrients of PFAA-contaminated corn silage were comparable with those of PFAA-free corn silage (Table 1). Crude ash content of PFAA-contaminated corn silage was not increased (\8 %); therefore, adhesion of soil causing high PFAA In the present study, sheep exposure to PFOA and PFOS by way of ''natural'' contaminated feed was 10-to 100-fold less than those used for kinetic studies with chicken NA not analysed (Yeung et al 2009;Yoo et al 2007) and rats (Vanden Heuvel et al 1991;Cui et al 2010). Comparison of plasma concentrations in wildlife found similar mean concentrations of PFOA and PFOS, ranging from 0.3 to 8 lg/L PFOA and from 0.8 to 74 lg/L PFOS, in panda from China (Dai et al 2006).…”

Section: Adsorption and Eliminationmentioning

confidence: 64%

Transfer of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) From Contaminated Feed Into Milk and Meat of Sheep: Pilot Study

Kowalczyk

Ehlers

Fürst

et al. 2012

Arch Environ Contam Toxicol

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A pilot study was performed with dairy sheep to generate the first data on the transfer of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) from feed into food of animal origin. Corn silage was cultivated on cropland in Lower Saxony in Germany where, as a result of illegal waste disposal in 2006, farmland was contaminated with perfluorinated alkylacids (PFAAs). Two sheep were exposed by way of PFAA-contaminated corn silage to PFOS (1.16 and 1.45 μg/kg body weight [bw]/d, respectively) and PFOA (0.43 and 0.53 μg/kg bw/d) during a period of 21 days. During the PFAA-feeding period, PFOS levels in plasma increased continuously to maximum concentration of 103 and 240 μg/L for sheep 1 and sheep 2, respectively. The PFOA plasma concentration remained low (sheep 1 = 3.3 ± 2.2 μg/L; sheep 2 = 15.6 ± 8.3 μg/L). Data indicate that urinary excretion is the primary clearance route for PFOA (sheep 1 = 51 %; sheep 2 = 55 %), whereas PFOS excretion by way of urine could not be quantified. The highest PFOS excretion (4 to 5 %) was detected in faeces. PFOS was also excreted at higher levels than PFOA by way of milk. During a period of 21 days, a total PFOS transfer into milk ≤ 2 % was calculated. Overall, total excretion of PFOS was significantly lower compared with that of PFOA (PFOS 6 %; PFOA 53 to 56 %). PFOS levels in sheep 1 and sheep 2 were highest in liver (885 and 1,172 μg/kg weight wet [ww], respectively) and lowest in muscle tissue (24.4 and 35.1 μg/kg ww, respectively). PFOA levels in muscle tissue were low for sheep 2 (0.23 μg/kg ww) and not detectable after the PFAA-free feeding period in sheep 1. A slight background load of PFOS in liver (1.5 μg/kg ww) and kidney (0.3 μg/kg ww) was detected in sheep 3 (control).

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Section: Adsorption and Eliminationmentioning

confidence: 64%

Transfer of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) From Contaminated Feed Into Milk and Meat of Sheep: Pilot Study

Kowalczyk

Ehlers

Fürst

et al. 2012

Arch Environ Contam Toxicol

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“…Those results support the idea that PFAS levels in eggs of the offshore species primarily reflect exposure during the 7 months/year to 8 months/ year both species spend on nonbreeding grounds rather than the 4 to 5 months/year that they spend at the breeding grounds [44], especially because nutrients in the eggs are deposited at the start of the breeding season, before they have several months' recent exposure. We suggest either that egg nutrients (including PFAS) are deposited at varying times after arriving from the nonbreeding grounds or that they are derived from tissues that have a longer PFAS half-life than the 14 to 20 days reported for some avian species [65] and may be similar to that seen in chicken serum [66]. However, clear differences are seen among the species; herons had the highest PFOS concentration, cormorants had the lowest concentrations of both dominant PFCAs, and the offshore species had the highest concentrations of dominant PFCAs.…”

Section: Species Differencesmentioning

confidence: 88%

Temporal trends of perfluoroalkyl substances (PFAS) in eggs of coastal and offshore birds: Increasing PFAS levels associated with offshore bird species breeding on the Pacific coast of Canada and wintering near Asia

Miller

Elliott

et al. 2015

Enviro Toxic and Chemistry

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Perfluoroalkyl substances (PFAS) such as perfluoroalkyl carboxylates (PFCAs) and perfluoroalkyl sulfonates (PFSAs) have become virtually ubiquitous throughout the environment, and, based on laboratory studies, have known toxicological consequences. Various national and international voluntary phase-outs and restrictions on these compounds have been implemented over the last 10 to 15 years. In the present study, we examine trends (1990/1991-2010/2011) in aquatic birds (ancient murrelet, Synthliboramphus antiquus [2009 only]; Leach's storm-petrels, Oceanodroma leucorhoa; rhinoceros auklets, Cerorhinca monocerata; double-crested cormorants, Phalacrocorax auritus; and great blue herons, Ardea herodias). The PFCA, PFSA, and stable isotope (δ(15) N and δ(13) C) data collected from these species from the Pacific coast of Canada, ranging over 20 to 30 years, were used to investigate temporal changes in PFAS coupled to dietary changes. Perfluorooctane sulfonic acid (PFOS), the dominant PFSA compound in all 4 species, increased and subsequently decreased in auklet and cormorant eggs in line with the manufacturing phase-out of PFOS and perfluorooctanoic acid (PFOA), but concentrations continuously increased in petrel eggs and remained largely unchanged in heron eggs. Dominant PFCA compounds varied between the offshore and coastal species, with increases seen in the offshore species and little or variable changes seen in the coastal species. Little temporal change was seen in stable isotope values, indicating that diet alone is not driving observed PFAS concentrations.

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“…High PFOS concentrations in biotic samples were also observed in other studies in China, including in blood samples from giant pandas and red pandas [36] , and in human blood samples [11,12] . A recent exposure and depuration experiment on chickens showed that PFOA was removed from the body more quickly than PFOS [37] . Therefore, it is likely that PFOS accumulation would occur in chickens and that PFOS might be transferred to the eggs at high concentrations.…”

Section: Dietary Survey and Risk Assessmentmentioning

confidence: 99%

Perfluorooctane sulfonate (PFOS) and related fluorochemicals in chicken egg in China

et al. 2008

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The ubiquitous occurrence of perfluorinated compounds (PFCs) in environmental samples has drawn much attention. Recent human exposure studies found relatively high perfluorooctane sulfonate (PFOS) concentrations in blood samples from several cities in China when compared with other countries. The objectives of the present study were: (1) to measure PFC concentrations and compositions in chicken egg samples from local markets in China; and (2) to conduct a preliminary human health risk assessment of egg consumption. Eight pooled egg samples from eight locations were analyzed for 11 PFCs. The results showed that close to 100% of the PFOS in the egg was distributed in egg yolk and PFOS was not detected in egg white (<0.08 ng/g wet weight, w/w). Of the perfluoroalkylsulfonates, only PFOS was detected in all egg samples, while of the perfluoroalkylcarboxylates, perfluoroundecanoic acid (PFUnDA) was detected in all samples, followed by perfluorooctanoate (PFOA) (75% occurrence) and perfluorodecanoic acid (PFDA) (50% occurrence). PFOS concentrations in egg ranged from 45.0 to 86.9 ng/g w/w. The results suggested that current concentrations of PFOS in domestic chicken eggs are unlikely to cause immediate harm to Chinese populations.PFOS, chicken egg, human health risk assessment, egg yolk, egg white Perfluorooctanesulfonate (PFOS), one of the most wellknown perfluorinated compounds (PFCs), is the endstage metabolite of many PFCs [1] . The strong carbonfluorine (C-F) covalent bond in PFCs accounts for the thermal and chemical stability of these compounds, which have been manufactured and used for a variety of industrial applications, such as surfactants and surface protectors, for over 50 years [2][3][4] . The ubiquitous occurrence of PFCs in environmental samples has drawn much attention [4] . In 2000, one of the fluorochemical manufacturing companies, the 3M Company, ceased the production of perfluorooctanyl-related materials because PFOS was found to be present in tissues of humans and wildlife [5] .Recent studies have demonstrated PFC contamination in China. PFCs were detected in the coastal seawaters of Hong Kong and the Zhujiang River Delta, as well as in waters from the Zhujiang and Yangtze rivers [6][7][8] . PFCs were also measured in seafood samples collected from Zhoushan and Guangzhou [9] and in mussel samples collected along the eastern coast of China [10] . Human exposure studies also showed relatively high PFOS concentrations in blood samples from several cities in China when compared with other countries [11,12] .Although there is no toxicological study of PFOS in humans thus far, the toxicity of PFOS has been studied in rats, mice, rabbits, and monkeys [13][14][15][16][17][18][19] . Reduced body weight, hepatocellular hypertrophy, and a decrease in serum cholesterol and triglycerides were observed in rats

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Depuration kinetics and tissue disposition of PFOA and PFOS in white leghorn chickens (Gallus gallus) administered by subcutaneous implantation

Cited by 77 publications

References 26 publications

Transfer of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) From Contaminated Feed Into Milk and Meat of Sheep: Pilot Study

Transfer of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) From Contaminated Feed Into Milk and Meat of Sheep: Pilot Study

Temporal trends of perfluoroalkyl substances (PFAS) in eggs of coastal and offshore birds: Increasing PFAS levels associated with offshore bird species breeding on the Pacific coast of Canada and wintering near Asia

Perfluorooctane sulfonate (PFOS) and related fluorochemicals in chicken egg in China

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