2004
DOI: 10.1002/ange.200300645
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Der 2×3‐Werkzeugkasten der metallorganischen Methoden zur regiochemisch erschöpfenden Funktionalisierung

Abstract: Dieser Aufsatz stellt ein Konzept zur überschaubaren und umfassenden Strukturvermehrung vor. Dazu werden einfache aromatische oder heteroaromatische Ausgangsstoffe, oftmals Grundchemikalien, in alle regioisomer möglichen metallischen Zwischenstufen (meist Lithium‐Verbindungen) umgewandelt, die dann mit irgendeinem von zahllosen infrage kommenden Elektrophilen umgesetzt werden können, um auf diese Weise zu begehrten neuen Synthesebausteinen, insbesondere funktionellen Derivaten, zu gelangen. Die praktische Verw… Show more

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Cited by 104 publications
(9 citation statements)
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“…In the case of transition-metal-mediated directed oxidations, the conformational effects resulting from the intermediate metallacycles have a critical impact on chemoselectivity. [5] While the oxidation of benzene derivatives has a rich history dating back to early studies on electrophilic aromatic substitution and the Heck reaction, [72] research centered on metalmediated catalytic methods is a vibrant area of investigation.…”
Section: Activation Of Sp 2 Centersmentioning
confidence: 99%
“…In the case of transition-metal-mediated directed oxidations, the conformational effects resulting from the intermediate metallacycles have a critical impact on chemoselectivity. [5] While the oxidation of benzene derivatives has a rich history dating back to early studies on electrophilic aromatic substitution and the Heck reaction, [72] research centered on metalmediated catalytic methods is a vibrant area of investigation.…”
Section: Activation Of Sp 2 Centersmentioning
confidence: 99%
“…We thus aim to provide a method which allows one to predict the selectivity of halogen-magnesium exchange reactions of polyfunctional compounds. [7] Attempts to determine the kinetics of these reactions to reveal details of the reaction mechanisms have so far not been conclusive. Received: September 5, 2007Published online: November 23, 2007 .…”
mentioning
confidence: 99%
“…Let us consider an arene bearing two different heteroelements at 1- and 2-positions or 1- and 3-positions. Is it really possible to introduce further substituents optionally at any of the vacant positions by merely relying on a handful of advanced organometallic methods, as asserted recently? The only way to make this claim credible is to subject it to scrutiny by a variety of “tough” model cases. To this end, we have examined as substrates 3-fluorophenol, several difluorophenols and trifluorophenols, , 4-, 5-, 6-, and 7-fluoroindole, 4-bromo-6- and -7-fluoro-2-(trifluoromethyl)quinoline, N -methyl- and N -phenyl-5-(trifluoromethyl)pyrazole, various bromo-, chloro-, and iodo(trifluoromethyl)pyridines, 3-fluoropyridine, and 2,4-difluoropyridine …”
Section: Introductionmentioning
confidence: 99%