Der derzeitige Stand von MOF‐ und COF‐Anwendungen

Freund, Ralph; Zaremba, Orysia; Arnauts, Giel; Ameloot, Rob; Skorupskii, Grigorii; Dincă, Mircea; Bavykina, Anastasiya; Gascón, Jorge; Ejsmont, Aleksander; Gościańska, Joanna; Kalmutzki, Markus; Lächelt, Ulrich; Ploetz, Evelyn; Diercks, Christian S.; Wuttke, Stefan

doi:10.1002/ange.202106259

Cited by 39 publications

(29 citation statements)

References 286 publications

(470 reference statements)

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“…Metal-Organic Frameworks (MOFs) are mesoporous hybrid materials self-assembled by metal ions and organic ligands through coordination chemistry. [79] MOFs with porous structures can achieve high drug loading as well as protect proteins from degradation in the gastric environment. [21,80] Tian and co-authors reported an acid-resistant UiO-68-NH 2 constructed MOFs modified with transferrin to overcome the intestinal epithelial barrier for oral insulin (Figure 8a).…”

Section: Metal-organic Frameworkmentioning

confidence: 99%

“…[80b] Apart from MOFs, covalent organic frameworks (COFs), which are composed of organic elements and linked by covalent bonds, also have been applied for drug delivery. [79] Benyettou et al prepared nanoscale COFs as an oral insulin delivery system with a high insulin-loading capacity (65 wt %) due to the high surface area. [82]…”

Section: Metal-organic Frameworkmentioning

confidence: 99%

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Recent Advances in Oral and Transdermal Protein Delivery Systems

et al. 2022

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Protein and peptide drugs are predominantly administered by injection to achieve high bioavailability, but this greatly compromises patient compliance. Oral and transdermal drug delivery with minimal invasiveness and high adherence represent attractive alternatives to injection administration. However, oral and transdermal administration of bioactive proteins must overcome biological barriers, namely the gastrointestinal and skin barriers, respectively. The rapid development of new materials and technologies promises to address these physiological obstacles. This review provides an overview of the latest advances in oral and transdermal protein delivery, including chemical strategies, synthetic nanoparticles, medical microdevices, and biomimetic systems for oral administration, as well as chemical enhancers, physical approaches, and microneedles in transdermal delivery. We also discuss challenges and future perspectives of the field with a focus on innovation and translation.

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Section: Metal-organic Frameworkmentioning

confidence: 99%

Section: Metal-organic Frameworkmentioning

confidence: 99%

Recent Advances in Oral and Transdermal Protein Delivery Systems

et al. 2022

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“…Reticular chemistry has enabled chemists to link discrete molecular building blocks into designed structures such as metal–organic frameworks (MOFs) and covalent organic frameworks (COFs). [ 1–5 ] A target topology is first envisioned, and its nodes are matched by molecular units amenable to being linked together by strong bonds, as illustrated in Scheme . This process, termed augmentation, yields frameworks whose metrics can be precisely tailored by the size of the constituent building units so chosen.…”

Section: A Strategy For Synthesis Of Supercrystalsmentioning

confidence: 99%

From Molecules to Frameworks to Superframework Crystals

Freund

Diercks

et al. 2021

Advanced Materials

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Zhe Ji obtained his Ph.D. at UC Berkeley in the group of Prof. Omar M. Yaghi. After completing his bachelor's degree at Tsinghua University with Prof. Gaoquan Shi, he moved to Berkeley to pursue his doctorate in chemistry focusing on the design and synthesis of reticular materials. His research interest lies in bringing a high level of complexity and functionality to framework structures, through efforts in connecting metal-sulfur clusters, sequencing metals in multivariate systems, and building framework-bacteria interfaces. He is now a postdoc at Stanford University in the group of Prof. Steven G. Boxer.

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“…Concurrently, in the late 1990s, the research on molecular networks evolved toward stabilizing their structures even under vacuum, which provided the creation of permanent porosity in the networks [14,15]. This type of network is called "porous" metal-organic frameworks (MOFs) or "porous" CPs (PCPs), in which metal ions/clusters and anionic organic links are often used as building blocks [16][17][18][19][20]. By following the similar story that the solution chemistry of CCs/MOCs was initiated by cutting out the smallest unit from CPs, the researchers tried to synthesize the molecular counterpart of porous MOFs/PCPs and demonstrated the permanent porosity of CCs/MOCs by gas adsorption experiments in 2005 [21].…”

Section: Introductionmentioning

confidence: 99%

Coordination/Metal–Organic Cages Inside Out

Tateishi

Yoshimura

Tokuda

et al. 2022

Preprint

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Cage-like molecules, assembled by the coordination of multiple metal ions and organic links, are pushing new frontiers in science due to their design flexibility and the resulting diverse and unique chemical properties. This field has been advanced by two close but distinct chemistry communities. Consequently, the family of molecules referred to as coordination cages (CCs) constituted of metal-pyridine coordination bonds or metal–organic cages (MOCs) based on dinuclear tetracarboxylates paddlewheel complexes in each community had not been reviewed cross-sectionally, even though they are conceptually similar. This review article extracted and compared experimental information on a total of 197 CCs and 78 MOCs from 182 reports to identify their synthetic and structural signatures. We did not merely enumerate the reports we collected; we meta-analyzed the data extracted from the reports and highlighted both the similarities and dissimilarities between CCs and MOCs. As a result, we clarified the key parameters governing the synthetic conditions. Furthermore, we identified a new research direction by visualizing unexplored features and properties of CCs and MOCs. This review article provides a good tutorial both for researchers attempting to cross the boundary between CCs and MOCs and those who are new to the field.

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Der derzeitige Stand von MOF‐ und COF‐Anwendungen

Cited by 39 publications

References 286 publications

Recent Advances in Oral and Transdermal Protein Delivery Systems

Recent Advances in Oral and Transdermal Protein Delivery Systems

From Molecules to Frameworks to Superframework Crystals

Coordination/Metal–Organic Cages Inside Out

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