Der Ein-fluß der Hämodialyse auf den Hormonstatus terminal niereninsuffizienter Patienten

Investigation of the Hormonal Axis Hypothalamus-Pituitary-Gonads in 20 Dialyzed Men

“…-1977;Sy Lirn and Fang -1975;Bundschu et al -1976;Hrubesch et a]. -1973;Bundschu et al -1971;Mies et al -1975;Bundschu et al -1974;Bindeballe et al -1973). However, we feel that both the relatively weak slope of the initial rise and the relatively small total increase of the gonadotropins after stimulation with GnRH betoken a lesion at the level of the pituitary and/or the hypothalamus in patients with chronic renal failure.…”

“…In contrast, there is no definite evidence for an affection of the hypothalamic-pictuitary-system in patients on maintenance hemodialysis. While most studies demonstrated an intact re-action of the hypothalamus and/or the pituitary to stimulation and/or suppression (Holdsworth et al -1977;Sy Lim and Fang -1975;Bundschu et al 1976;Hrubesch et al -1973;Bundschuh et al -1971;Mies et al -1975;Bundschu et al -1974;Bindeballe et al -1973), "some degree of pituitary insensitivity" (Holdsworth et al -1977) as well as "heightened sensitivity of the hypothalamus" (Sy Lim et al -1975) have been suggested.…”