Der Einflu� von l-DOPA auf den Nachtschlaf bei Patienten mit Parkinson-Syndrom

Kendel, K.; Beck, U; Wita, C. W.; Hohneck, E; Zimmermann, Hans‐Joachim

doi:10.1007/bf00342499

Cited by 34 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Abnormal sleep patterns are common in patients with PD and in levodopa-treated patients (Kendel et al, 1972). These patients sleep poorly, with frequent wakenings associated with reduced REM sleep (Apps et al, 1985;Kales et al, 1971;Kendel et al, 1971;Kendel et al, 1972;Traczynska et al, 1969).…”

Section: R Sandykmentioning

confidence: 94%

See 1 more Smart Citation

Pineal Melatonin Functions: Possible Relevance to Parkinson's Disease

Sandyk

1990

International Journal of Neuroscience

View full text Add to dashboard Cite

Barbeau hypothesized that Parkinson's disease is associated with hypothalamic deficiency of the specialized neuroendocrine cell system (A.P.U.D.) and that the degeneration of brainstem monoaminergic neurons is secondary to progressive functional loss of this cell system in the disease. The pineal gland meets criteria of the A.P.U.D. cell system and it is possible that dysfunction of the pineal gland may be associated with the pathophysiology and clinical manifestations of Parkinson's disease. Since the role of pineal melatonin in humans remains enigamatic, it is currently unclear which of the symptoms of Parkinson's disease may be associated with deregulation of the secretory activity of pineal melatonin. This review summarizes evidence linking possible alterations of pineal melatonin functions with the clinical manifestations of Parkinson's disease.

show abstract

Section: R Sandykmentioning

confidence: 94%

“…These patients sleep poorly, with frequent wakenings associated with reduced REM sleep (Apps et al, 1985;Kales et al, 1971;Kendel et al, 1971;Kendel et al, 1972;Traczynska et al, 1969). On falling asleep, patients with PD lose their rigidity and tremor (Apps et al, 1985).…”

Section: R Sandykmentioning

confidence: 96%

Pineal Melatonin Functions: Possible Relevance to Parkinson's Disease

Sandyk

1990

International Journal of Neuroscience

View full text Add to dashboard Cite

show abstract

“…The underlying causes for sleep disorders in PD patients are still discussed controversially. It may be due to the disease itself with its underlying immobility (7, 8, 33, 42), due to the impact of dopaminergic medication (7, 8, 22, 24, 31, 36, 40, 46, 47) or due to a concomitant depression (14). Depression in PD patients also shows a highly inconsistent prevalence of 4% to 70% in different studies (7–9, 23, 27–29, 35, 38, 41, and personal data).…”

mentioning

confidence: 99%

Sleep disorders and depression in patients with Parkinson's disease

Happe

Schrödl

Faltl

et al. 2001

Acta Neurologica Scandinavica

View full text Add to dashboard Cite

The significant higher narcolepsy score in PD patients must be seen due to dopaminergic medication and PD-specific neurodegeneration and immobility rather than due to narcolepsy. This leads to the conclusion that extreme caution is advised when carrying out the SDQ and interpreting the results in various persons and patient groups with motor problems. The strong association of depression, disease severity and sleep disorders in PD patients underlines the importance of identifying and treating both conditions in these patients.

show abstract

“…Successive sleep laboratory studies in patients affected by Parkinson's disease (PD) show a wide variety of abnor malities: increased sleep latency, frequent arousals, increased time spent awake [2][3][4], as well as a reduction in non-REM stages 3 and 4 and/or REM sleep [2,[5][6][7], In other studies normal sleep architecture has been described [8,9], These discrepancies seem to be related to the lack of homogeneity of patients, as far as etiology, severity or duration of the disease arc concerned.…”

Section: Introductionmentioning

confidence: 99%

Respiration and Heart Rate Variability during Sleep in Untreated Parkinson Patients

Ferini‐Strambi¹,

Franceschi²,

Pinto³

et al. 1992

Gerontology

View full text Add to dashboard Cite

Twenty-six patients with untreated mild to moderate Parkinson’s disease (PD) lasting 5 years or less, were investigated in the sleep laboratory. Sleep architecture and respiration during sleep did not significantly differ from age-matched controls. PD patients showed defective cardiac autonomic control during sleep, mainly parasympathetic but also sympathetic in nature, although they had normal results in conventional autonomic tests during wakefulness. Therefore, autonomic cardiac involvement seems to be an early sign of PD.

show abstract

Der Einflu� von l-DOPA auf den Nachtschlaf bei Patienten mit Parkinson-Syndrom

Cited by 34 publications

References 14 publications

Pineal Melatonin Functions: Possible Relevance to Parkinson's Disease

Pineal Melatonin Functions: Possible Relevance to Parkinson's Disease

Sleep disorders and depression in patients with Parkinson's disease

Respiration and Heart Rate Variability during Sleep in Untreated Parkinson Patients

Contact Info

Product

Resources

About