Der Einfluss des Nervensystems auf die Regeneration

Locatelli, P.

doi:10.1007/bf02078924

Cited by 38 publications

(2 citation statements)

References 14 publications

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“…This phenomenon has been demonstrated for a variety of species and organs; for example, fin regeneration in the teleost Fundulus also requires a nerve supply [14]. Furthermore, surgical supplementation of nervous system tissue has been reported to facilitate ectopic limb outgrowth from uninjured limbs of adult salamanders [15], and even to support regenerative events in amputated hindlimbs of the neonatal opossum [16]. Through the years, candidate neurotrophic factors have included Fgfs, neuregulin, transferrin, and other molecules, but none of these have fulfilled all relevant properties, including: 1) presence in limb nervous tissue; 2) activity as a blastemal mitogen; and 3) ability to rescue regeneration of a denervated and amputated limb [17-19].…”

Section: Nag Directs Newt Limb Regeneration From the Nervementioning

confidence: 99%

New regulators of vertebrate appendage regeneration

Yin

Poss

2008

Current Opinion in Genetics & Development

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Appendage regeneration is a complex and fascinating biological process exhibited in vertebrates by urodele amphibians and teleost fish. A current focus in the field is to identify new molecules that control formation and function of the regeneration blastema, a mass of proliferative mesenchyme that emerges after limb or fin amputation and serves as progenitor tissue for lost structures. Two studies published recently have illuminated new molecular regulators of blastemal proliferation. After amputation of a newt limb, the nerve sheath releases nAG, a blastemal mitogen that facilitates regeneration. In amputated zebrafish fins, regeneration is optimized through depletion of the microRNA miR-133, a mechanism that requires Fgf signaling. These discoveries establish research avenues that may impact the regenerative capacity of mammalian tissues.

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Section: Nag Directs Newt Limb Regeneration From the Nervementioning

confidence: 99%

New regulators of vertebrate appendage regeneration

Yin

Poss

2008

Current Opinion in Genetics & Development

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“…2C). First described by Locatelli in 1929 67 and first thoroughly characterized with modern techniques by Endo, Bryant and Gardiner in 2004, 68 the ALM elegantly demonstrates the necessity of peripheral nerves for blastema formation. Inducing a wound in the epidermis and then deviating a peripheral nerve beneath this wound results in the formation of a proliferating bump.…”

Section: Molecular Mechanisms Of Nerve Dependencementioning

confidence: 99%

A brief history of the study of nerve dependent regeneration

Farkas

Monaghan

2017

Neurogenesis

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Nerve dependence is a phenomenon observed across a stunning array of species and tissues. From zebrafish to fetal mice to humans, research across various animal models has shown that nerves are critical for the support of tissue repair and regeneration. Although the study of this phenomenon has persisted for centuries, largely through research conducted in salamanders, the cellular and molecular mechanisms of nerve dependence remain poorly-understood. Here we highlight the near-ubiquity and clinical relevance of vertebrate nerve dependence while providing a timeline of its study and an overview of recent advancements toward understanding the mechanisms behind this process. In presenting a brief history of the research of nerve dependence, we provide both historical and modern context to our recent work on nerve dependent limb regeneration in the Mexican axolotl.

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A ventral accessory tail in Triturus viridescens and its duplication experimentally

Dawson

1932

Anat. Rec.

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Der Einfluss des Nervensystems auf die Regeneration

Cited by 38 publications

References 14 publications

New regulators of vertebrate appendage regeneration

New regulators of vertebrate appendage regeneration

A brief history of the study of nerve dependent regeneration

A ventral accessory tail in Triturus viridescens and its duplication experimentally

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