Der Einfluss von Methionin auf die Wirkungs-Dauer verschiedener Kurznarkotica

Heise, E; Kimbel, K. H.

doi:10.1007/bf01472802

Cited by 1 publication

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“…depending to some extent on the the vaccinated rat, symptoms identical to those age of the animal. These figures agree with the described for the normal animal were observed findings of Heise and Kimbel (1955). Daily ECG However, whereas the normal rat after a certain riod of the samese were taken contime completely recovered, the conditions of the period of five days; these were remarkably convaccinated animal progressively deteriorated until stant only minor modifications being noted it died.…”

Section: Guinea-pig Failed To Become More Histamine-supporting

confidence: 90%

SOME EFFECTS OF HISTAMINE IN THE NORMAL AND HAEMOPHILUS PERTUSSIS VACCINATED RAT

Bovet

Kohn

Marotta

et al. 1958

British Journal of Pharmacology and Chemotherapy

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The effects of histamine in the normal and H. pertussis vaccinated rat have been investigated. In the normal animal small doses of histamine (from 1 to 30 mg./kg., i.v.) produced significant, reversible alterations in the blood pressure, electrocardiogram and electroencephalogram. Doses of 100 mg./kg. or more caused bronchoconstriction and doses of 200 mg./kg. or more an effect on the muscular contractions after electrical stimulation of the nerve. Acute histamine intoxication resulted on rapid injection of 500 mg./kg. intravenously; death was probably due to cardiovascular collapse. In the vaccinated rat, a distinction could be made between the immediate and delayed effects of histamine. With a sublethal dose of histamine (5 mg./kg.) alterations in the blood pressure, electrocardiogram and electroencephalogram were noted. The neuromuscular system, which in the normal animal was the least reactive to histamine, showed the most marked increase in sensitivity in the vaccinated rat. The delayed effects of histamine observed after an interval of 5 to 30 min. were characteristic and irreversible, leading to death of the animal. The mechanism of death in the vaccinated rat after histamine appears to differ from that of the normal animal and has been discussed in the light of present knowledge.

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Section: Guinea-pig Failed To Become More Histamine-supporting

confidence: 90%