Der Einsatz der Magnetresonanztomographie der Muskulatur bei der Diagnose neuromuskulärer Erkrankungen

Schrank, Bertold; Lörcher, U.

doi:10.1007/s00062-005-6419-1

Cited by 6 publications

(16 citation statements)

References 34 publications

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“…3). These volumes differed between the different used sequences showing different pathologic reactions as described in the literature (Lovitt et al, 2006;May et al, 2000;Schrank et al, 2005):…”

Section: Tab 4: Results Of the Paired T-test To Identify Volume Diffmentioning

confidence: 94%

“…In human studies, MRI is used to detect alterations in muscle tissue (Lovitt et al, 2006;May et al, 2000;Schrank et al, 2005). By choosing different sequence parameters for MR imaging, a multitude of pathologic conditions can be illustrated (Berquist et al, 1985;Hodgson, 2010).…”

Section: Tab 4: Results Of the Paired T-test To Identify Volume Diffmentioning

confidence: 99%

“…Different pathologic conditions are described in the literature like hematoma, edema, fatty infiltration or inflammation, which result in alterations in tissue parameters and therefore in an illustration in T1-or T2-weighted MR images. These pathologic conditions result in areas with increased signal intensity in T1-and T2-weighted MR images (Lovitt et al, 2006;May et al, 2000;Schrank et al, 2005). In this study image evaluation was performed by evaluating volumes of regions with hyperintense signals at the VS and CS (see Fig.…”

Section: Tab 4: Results Of the Paired T-test To Identify Volume Diffmentioning

confidence: 99%

“…This depends on different relaxation times: transversal (T1) and longitudinal (T2) relaxation time (for further information see Pipe, 1999or Hodgson, 2010. Depending on the used sequence weighting, different pathologic conditions can be visualized and result in areas (volumes) with increased signal intensity (Lovitt et al, 2006;May et al, 2000;Schrank et al, 2005). For this study, T1-and T2-weighted spin echo sequences with two directions of acquisition (axial and coronary; only results for the coronary acquisition are displayed) were applied (see Tab.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

“…Muscle signal intensity can be affected by various conditions such as trauma, infection or inflammation. These abnormalities effect an alteration in tissue parameters and cause differences in signal intensity in the image, as well as in muscle size and profile (Lovitt et al, 2006;May et al, 2000;Schrank et al, 2005). The ability to detect these alterations makes MRI a useful tool in diagnosis and follow-up of musculoskeletal diseases in humans (Lovitt et al, 2006;Messineo et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Safety testing of veterinary vaccines using magnetic resonance imaging in pigs

Bernau

Kremer

Pappenberger

et al. 2015

ALTEX

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SummarySafety testing of veterinary vaccines requires the use of a large number of animals to investigate possible local and systemic reactions. This includes, among others, the pathological examination of the injection site in frequent intervals. This examination requires a selected killing of animals in frequent intervals. To reduce the number of animals needed for this kind of safety testing, magnetic resonance imaging (MRI) was used to detect and quantify possible local reactions after vaccination in vivo. Sixty-four pigs were divided into four experimental groups (n = 16); two groups consisting of 12-week-old pigs and two of 6-month-old pigs at vaccination day. The pigs were vaccinated with four licensed products (each group receiving one vaccine) and examined up to 6 times using MRI during a period of 5 weeks. The MR images were evaluated semi-automatically, comparing the volumes of altered signal intensities on the vaccination side (VS) with the volumes of the signal intensities on the control side (CS). A paired t-test was used to identify significant differences (p < 0.05) between VS and CS. The results show that MRI allows a 3D-quantification of the extent of local reactions in vivo by scanning the same live animals at several time points after vaccination. MRI is a suitable alternative method for non-invasive safety testing of injectable medicines and can therefore be applied to reduce animal numbers used for safety testing purposes.

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Section: Tab 4: Results Of the Paired T-test To Identify Volume Diffmentioning

confidence: 94%

Section: Tab 4: Results Of the Paired T-test To Identify Volume Diffmentioning

confidence: 99%

Section: Tab 4: Results Of the Paired T-test To Identify Volume Diffmentioning

confidence: 99%

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Safety testing of veterinary vaccines using magnetic resonance imaging in pigs

Bernau

Kremer

Pappenberger

et al. 2015

ALTEX

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Kernspintomographie der Skelett- und Herzmuskulatur, des zentralen Nervensystems

Schrank¹

2014

Klinik Und Transition Neuromuskulärer Erkrankungen

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Vaccine safety testing using magnetic resonance imaging in suckling pigs

Bernau

Liesner

Schwanitz

et al. 2018

Vaccine

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Safety testing is one major part of the licensing procedure for veterinary vaccines and demands a large number of animals. Magnetic resonance imaging (MRI) was tested as an alternative, which may lead to a reduction in numbers of animals required for safety testing, and, correspondingly to a detailed description of the three-dimensional extent of the local tissue reaction repetitively in live pigs. In previous pig studies the following questions arose:To answer these questions the following study was performed by comparing two vaccine groups of suckling piglets (8 animals per group; A and B) with two control groups (4 animals per group; C and D). One control group was injected with a saline solution (C) and the other was only tattoo marked (D). The animals were examined using MRI at days 1, 8, 15, 22, 29, 36, and 43 post vaccination, ending with a final pathomorphologic examination. Pathomorphologic examination confirmed MRI findings. Saline solution does not result in a local tissue reaction as detected after injecting vaccines. Tattoo marking causes no local tissue reaction, neither in MRI nor in pathomorphologic examination. Therefore, MRI can be used as an alternative method for safety testing of vaccines in pigs of different age categories offering repetitive measurements of local tissue reactions. Involved cells might be examined only in a final pathomorphologic examination at the end of the trial on a reduced number of animals.

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Der Einsatz der Magnetresonanztomographie der Muskulatur bei der Diagnose neuromuskulärer Erkrankungen

Cited by 6 publications

References 34 publications

Safety testing of veterinary vaccines using magnetic resonance imaging in pigs

Safety testing of veterinary vaccines using magnetic resonance imaging in pigs

Kernspintomographie der Skelett- und Herzmuskulatur, des zentralen Nervensystems

Vaccine safety testing using magnetic resonance imaging in suckling pigs

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