Der Elektrophorese-Mobilitäts-(EM-)Test bei präinvasiven dysplastischen Epithelveränderungen an der Portio vaginalis uteri

Abstract

The electrophoresis mobility test (EM) is credited with an accuracy of 70-90% for the diagnosis of gynaecological malignancies. The test was done in 21 patients with dysplasia of carcinoma in situ of the uterine cervix, 34 patients without malignant or pre-malignant gynaecological findings and 27 women who were not in medical care at the time of the test. The correlation between the EM test and cervical intra-epithelial neoplasia was thus tested. In patients with dysplasia or carcinoma in situ of the cervix the test was positive in over 80%. False positive tests were found in 35% of the patients with non-malignant or pre-malignant gynaecological findings and in 11% of the 27 patients not in medical care. Despite the possibility of regression of the cervical intra-epithelial neoplasia an identical precentage of patients to those with invasive carcinomas of the cervix showed a positive EM test. The density of lymphocytic cells in the dysplastic epithelium of the cervix was also investigated. A correlation between the migration and inhibition in the EM test and the number of lymphocytic cells in the dysplastic epithelium was not found.